| Item (SKU) | Specifications | Is In Stock | Price | Qty |
|---|---|---|---|---|
|
P412000-100μg (Trial Size) Apply for free trial size（?） The same customer can apply for trial packaging three times a year, while the same product can only apply for trial packaging once a year
|
100μg |
Out of Stock  |
| |
|
P412000-1mg |
1mg |
In Stock |
| |
|
P412000-5mg |
5mg |
In Stock |
| |
|
P412000-10mg |
10mg |
Out of Stock |
|
| Name | Pertuzumab (anti-HER2) |
|---|---|
| Specifications & Purity | 96% |
| Specificity | ERBB2/HER2/CD340 |
| Species reactivity（Reacts with) | Human,Mouse?,Rat? |
| Antibody Type | Primary antibody |
|---|---|
| Format | Whole IgG |
| Isotype | Human IgG1 |
| Light Chain Type | Kappa |
| SDS-PAGE | 145.44 kDa |
| Purification Method | Protein A purified |
| Purity | >95% |
| Form | Liquid |
| Storage buffer/Formulation | Supplied as a 0.22 μm filtered solution in 100mM Pro-Ac, 20mM Arg, pH 5.0 |
| Preservatives | No |
| Concentration | Lot by Lot |
| Stability and Storage | Store at -80℃ for 24 months. Upon delivery aliquot. Avoid freeze/thaw cycle. |
| CAS Number | 380610-27-5 |
| Wikipedia | Pertuzumab |
|---|---|
| IMGT/mAb-DB | 80 |
| PubChem SID | 178101741 |
| Reactome Reaction | R-HSA-9665726, R-HSA-9665703, R-HSA-9665708 |
| Reactome Drug | R-ALL-9665971 |
| Ligand ID | 5046 |
|---|---|
| ligand_name | pertuzumab |
| synonyms | Omnitarg® (obsolete trade name) |
| ligand_type | Antibody |
| iupac_name | 4-amino-N-(4,6-dimethylpyrimidin-2-yl)benzenesulfonamide |
| bioactivity_comments |
The sulfonamide class of antibacterial compounds are primarily bacteriostatic agents and have a broad spectrum of activity against both Gram-positive and Gram-negative species of bacteria (reviewed in |
| comments | Annotated peptide sequences for this antibody are available in its IMGT/mAB-DB record. |
| one_letter_seq | |
| three_letter_seq | |
| post_translational_modifications | |
| chemical_modifications |
Pertuzumab (anti-HER2) (P412000) - Flow Cytometry
Flow Cytometry analysis of MCF-7 cells labelling HER2 (red) with Pertuzumab (anti-HER2) (P412000). Goat Anti-Human IgG (PE) (Ab175838) at a dilution of 1/1000 was used as the secondary antibody. Blue - Isotype control, human IgG (Ab170213). Black - Unlabelled control, cells without incubation with primary antibody.
Pertuzumab (anti-HER2) (P412000) - SEC
The purity of Pertuzumab (anti-HER2) (P412000) is more than 95% verified by HPLC.
Pertuzumab (anti-HER2) (P412000) - ELISA
Immobilized HER2-23-652-his at 2 μg/mL can bind Pertuzumab (anti-HER2) (P412000) with the EC?? of 13.75 ng/mL.
| 1. Badache A, Hynes NE. (2004) A new therapeutic antibody masks ErbB2 to its partners.. Cancer Cell, 5 (4): (299-301). [PMID:15093533] |
| 2. Ferguson KM. (2004) Active and inactive conformations of the epidermal growth factor receptor.. Biochem Soc Trans, 32 (Pt 5): (742-5). [PMID:15494003] |
| 3. Adams CW, Allison DE, Flagella K, Presta L, Clarke J, Dybdal N, McKeever K, Sliwkowski MX. (2006) Humanization of a recombinant monoclonal antibody to produce a therapeutic HER dimerization inhibitor, pertuzumab.. Cancer Immunol Immunother, 55 (6): (717-27). [PMID:16151804] |
| 4. Harbeck N, Beckmann MW, Rody A, Schneeweiss A, Müller V, Fehm T, Marschner N, Gluz O, Schrader I, Heinrich G et al.. (2013) HER2 Dimerization Inhibitor Pertuzumab - Mode of Action and Clinical Data in Breast Cancer.. Breast Care (Basel), 8 (1): (49-55). [PMID:24715843] |
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