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(7-Azabenzotriazol-1-yloxy)tripyrrolidinophosphonium hexafluorophosphateStarting at CN￥29.90
CAS : 156311-83-0
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Reagents for Peptide Synthesis
Polypeptide is a compound formed by dehydration and condensation of less than 100 amino acids. Its molecular structure is between amino acids and proteins and has high biological activity. With the wide application of peptides in drug research and development, food research and cosmetics (especially the development of biopharmaceuticals), peptide synthesis has become an important and growing field of chemical biology research.Peptide condensation reagentAt present, in peptide synthesis, carboxyl activation method is mainly used to complete the peptide reaction. The earliest method is to activate amino acids into acyl chloride, azide, symmetrical anhydride and mixed anhydride. However, due to the racemization of amino acids, the danger of reaction reagents and the complexity of preparation under these conditions, it is gradually replaced by later condensation reagents, According to its structure, it can be divided into two types: Aladdin condensation reagent mainly includes carbodiimide type and uranium salt type.Carbodiimide typeAladdin carbodiimide condensation reagents mainly include: DCC, DIC, EDC HCl et al. DCC is used for reaction. Because the DCU generated in the reaction has little solubility in DMF and produces white precipitation, it is generally not used in solid-phase synthesis. However, due to its low price, it can be removed by filtration in liquid-phase synthesis, which is still widely used. EDC. Because of its water solubility, HCl is often used in the connection between peptides and proteins, and it is also quite successful. However, one of the biggest disadvantages of this type of condensation reagent is that if it is used alone, there will be many side reactions, but the research shows that if HOBt, hoat and other reagents are added in the activation process, the side reactions can be controlled in a very low range.UroniumAladdin Uronium?salt condensation reagent has high reaction activity and fast speed. It is now widely used, mainly including HBTU, tbtu, Hatu, pybop, etc. Organic bases such as diisopropyl ethylamine (diea) and N-Methylmorpholine (NMM) need to be added during the use of the reagent. Amino acids can be activated only after the reagent is added.
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