Cas(1077-28-7), DL-Thioctic acid-Aladdin, DL-α-Lipoic Acid; DL-Thioctic Acid; 1,2-Dithiolane-3-valeric acid; DL-6,8-Dithiooctanoic acid; (±)-α-Lipoic acid; Lip(S2),

Item (SKU)	Specifications	Is In Stock
T106640-5g	5g	In Stock
T106640-25g	25g	In Stock
T106640-100g	100g	In Stock
T106640-500g	500g	In Stock

Basic Description

Specifications & Purity	99%
English Name	DL-Thioctic acid
Synonyms	DL-α-Lipoic Acid; DL-Thioctic Acid; 1,2-Dithiolane-3-valeric acid; DL-6,8-Dithiooctanoic acid; (±)-α-Lipoic acid; Lip(S2)
synonyms	thioctic acid\|dl-Thioctic acid\|1077-28-7\|alpha-Lipoic acid\|5-(1,2-Dithiolan-3-yl)pentanoic acid\|1,2-dithiolane-3-pentanoic acid\|DL-alpha-Lipoic acid\|alpha Lipoic Acid\|Biletan\|62-46-4\|6,8-Thioctic acid\|Thioctacid\|DL-6,8-Thioctic acid\|dl-Lipoic acid\|6-Thioc
Biochem Physiol	Non-specific free radical scavenger. Prevents lipid peroxidation and promotes mitochondrial permeability transition in vitro . Anti-oxidant. Active in vivo and in vitro .
Application	抗氧化剂和作为如丙酮酸脱氢酶(pyruvate dehydrogenase）和甘氨酸脱羧酶（glycine decarboxylase）的辅酶，外源性硫辛酸被细胞内两种或多种酶还原。这种还原形式影响了细胞清除自由基的进程。增加谷胱甘肽(glutathione)合成, 调控转录因子活性。降低了巨噬细胞髓磷脂的吞噬作用。 α-LA可以恢复高脂肪喂养的糖尿病大鼠的内皮活动，并减轻氧化应激。它还用于分析星形胶质细胞中的ROS 产生。
Storage Temp	Store at 2-8°C,Argon charged
Shipped in	Wet ice
Notes	Wherever possible, you should prepare and use solutions on the same day. However, if you need to make up stock solutions in advance, we recommend that you store the solution as aliquots in tightly sealed vials at -20°C. Generally, these will be useable for up to one month. Before use, and prior to opening the vial we recommend that you allow your product to equilibrate to room temperature for at least 1 hour. Need more advice on solubility, usage and handling? Please visit our frequently asked questions (FAQ) page for more details.
General description	α-Lipoic acid (LA), a nutritional component found in vegetables and meat, has both antioxidant and oxidant properties. LA exerts therapeutic potential to many diseases like liver cirrhosis, heavy metal poisoning, and diabetic polyneuropathy. LA exerts apoptotic potential in cancer cells either by oxidative stress related pathway or by activation of caspases. DL-Thioctic acid acid has been used in in vitro lipoylation studies and in the pyruvate dehydrogenase complex (PDC)-pyruvate dehydrogenase kinase (PDHK) functional assay.It has also been used to investigate its antioxidative effect on developing cerebellum of rats exposed to arsenic during postnatal period; DL-Thioctic acid can reinstate endothelial activities and alleviate oxidative stress in high-fat fed diabetic rats. It has also been used to analyze ROS production in astrocytes α-Lipoic acid (LA), a nutritional component found in vegetables and meat, has both antioxidant and oxidant properties. LA exerts therapeutic potential to many diseases like liver cirrhosis, heavy metal poisoning, and diabetic polyneuropathy. LA exerts apoptotic potential in cancer cells either by oxidative stress related pathway or by activation of caspases. DL-Thioctic acid acid has been used in in vitro lipoylation studies and in the pyruvate dehydrogenase complex (PDC)-pyruvate dehydrogenase kinase (PDHK) functional assay.It has also been used to investigate its antioxidative effect on developing cerebellum of rats exposed to arsenic during postnatal period; DL-Thioctic acid can reinstate endothelial activities and alleviate oxidative stress in high-fat fed diabetic rats. It has also been used to analyze ROS production in astrocytes

Names and Identifiers

EC Number	214-071-2
IUPAC Name	5-(dithiolan-3-yl)pentanoic acid
INCHI	InChI=1S/C8H14O2S2/c9-8(10)4-2-1-3-7-5-6-11-12-7/h7H,1-6H2,(H,9,10)
InChi Key	AGBQKNBQESQNJD-UHFFFAOYSA-N
Canonical SMILES	C1CSSC1CCCCC(=O)O
WGK Germany	3
RTECS	JP1192000
PubChem CID	864
Molecular Weight	206.33
Beilstein号	81853
Reaxy-Rn	81851

Chemical and Physical Properties

Solubility	Soluble in methanol, ethanol, diethyl ether and chloroform. Insoluble in water.
Sensitivity	Air & Moisture & Heat & Light Sensitive
Boil point(°C)	160-165℃
Melt point(°C)	62°C

Safe Information

Pictograms	Environmental Hazard Harmful
Signal word	Warning
Hazard statements	H315: Causes skin irritation H319: Causes serious eye irritation H411: Toxic to aquatic life with long lasting effects H302: Harmful if swallowed H317: May cause an allergic skin reaction
Precautionary statements	P261,P305+P351+P338,P273,P280,P302+P352,P321,P501,P264,P270,P272,P333+P313,P362+P364,P391,P330,P264+P265,P301+P317,P337+P317,P332+P317
WGK Germany	3
RTECS	JP1192000
Reaxy-Rn	81851
Merck Index	9326
Personal Protective Equipment	dust mask type N95 (US),Eyeshields,Gloves

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Bibliography

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DL-Thioctic acid

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DL-Thioctic acid

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