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Butein

Dual c-Met and EGFR tyrosine kinase inhibitor

Specification or purity: ≥98.0%(HPLC)

In stock

Butein

MSDS

COA

Stock Information

Item (SKU)	Specifications	Is In Stock
B135922-100mg	100mg	In Stock
B135922-500mg	500mg	In Stock
B135922-1g	1g	In Stock

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Basic Description

Specifications & Purity	≥98.0%(HPLC)
English Name	Butein
Synonyms	(E)-1-(2,4-Dihydroxyphenyl)-3-(3,4-dihydroxyphenyl)-2-propen-1-one;2',3,4,4'-Tetrahydroxychalcone
synonyms	butein\|487-52-5\|2',3,4,4'-Tetrahydroxychalcone\|2',4',3,4-Tetrahydroxychalcone\|3,4,2',4'-Tetrahydroxychalcone\|(E)-1-(2,4-dihydroxyphenyl)-3-(3,4-dihydroxyphenyl)prop-2-en-1-one\|AC1NQY7L\|UNII-4WVS5M0LGF\|4WVS5M0LGF\|EINECS 207-659-5\|CHEBI:3237\|NSC-652892\|(2E)
Biochem Physiol	Dual c-Met and EGFR tyrosine kinase inhibitor. Inhibits MMP-9 expression and activity. Suppresses tumor cell invasion. Induces apoptosis. Shows anti-adipogenic effects. Shows antimetastatic and antitumor effects in vivo.
Storage Temp	Store at -20°C,Argon charged
Shipped in	Dry ice
Notes	Wherever possible, you should prepare and use solutions on the same day. However, if you need to make up stock solutions in advance, we recommend that you store the solution as aliquots in tightly sealed vials at -20°C. Generally, these will be useable for up to one month. Before use, and prior to opening the vial we recommend that you allow your product to equilibrate to room temperature for at least 1 hour. Need more advice on solubility, usage and handling? Please visit our frequently asked questions (FAQ) page for more details.
General description	Butein, a plant polyphenol isolated from Rhus verniciflua, is able to inhibit the activation of protein tyrosine kinase, NF-κB and STAT3, also inhibits EGFR. Butein, a plant polyphenol isolated from Rhus verniciflua, is able to inhibit the activation of protein tyrosine kinase, NF-κB and STAT3, also inhibits EGFR.

Names and Identifiers

IUPAC Name	(E)-1-(2,4-dihydroxyphenyl)-3-(3,4-dihydroxyphenyl)prop-2-en-1-one
INCHI	InChI=1S/C15H12O5/c16-10-3-4-11(14(19)8-10)12(17)5-1-9-2-6-13(18)15(20)7-9/h1-8,16,18-20H/b5-1+
InChi Key	AYMYWHCQALZEGT-ORCRQEGFSA-N
Canonical SMILES	C1=CC(=C(C=C1C=CC(=O)C2=C(C=C(C=C2)O)O)O)O
WGK Germany	3
PubChem CID	5281222
Molecular Weight	272.25
Reaxy-Rn	2056928

Chemical and Physical Properties

Solubility	Soluble in Methanol
Sensitivity	Heat,Light &Air Sensitive
Melt point(°C)	215°C(lit.)

Safe Information

WGK Germany	3
Reaxy-Rn	2056928
Personal Protective Equipment	Eyeshields， Gloves， type N95 (US)， type P1 (EN143) respirator filter

Document Information

Quality Inspection Report COA

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SDS-CN SDS-EN

Specification Sheet

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