Cas(59122-46-2), 米索前列醇-阿拉丁试剂, ,Misoprostol,

货号 (SKU)	包装规格	是否现货
M121725-1mg	1mg	现货
M121725-5mg	5mg	现货
M121725-10mg	10mg	现货

基本描述

规格或纯度	98%
英文名称	Misoprostol
别名	(±)-15-Deoxy-(16RS)-16-hydroxy-16-methylprostaglandin E1 methyl ester
英文别名	(±)-15-Deoxy-(16RS)-16-hydroxy-16-methylprostaglandin E1 methyl ester
生化机理	PGE1 analog prodrug which is rapidly de-esterified to active "misoprostolic acid". Cited for extremely wide-ranging therapeutic effects, including prevention of NSAID-induced gastric ulceration, regulation of immunologic cascades, inhibition of platelet-activating factor (PAF), treatment of ethanol- and acetaminophen-induced hepatotoxicity and hepatitis, and stimulation of cartilage repair after injury.
储存温度	-20°C储存
运输条件	超低温冰袋运输
备注	如果按照产品小瓶上的说明进行存放，并且小瓶保持紧密密封，则产品最多可存放6个月。在使用前和打开样品瓶之前，我们建议您让您的产品在室温下平衡至少1小时。需要更多关于溶解度，用法和处理的建议吗？请访问我们的常见问题（FAQ）页面以获取更多详细信息。
产品介绍	产品介绍产品为乙酸甲酯溶液，包装以溶质含量计 Cytoprotective PGE₁ analog that prevents NSAID-induced gastric ulceration. PGE₁ analog prodrug which is rapidly de-esterified to active "misoprostolic acid". Cited for extremely wide-ranging therapeutic effects, including prevention of NSAID-induced gastric ulceration, regulation of immunologic cascades, inhibition of platelet-activating factor (PAF), treatment of ethanol- and acetaminophen-induced hepatotoxicity and hepatitis, and stimulation of cartilage repair after injury.

名称和标识符

IUPAC Name	methyl 7-[(1R,2R,3R)-3-hydroxy-2-[(E)-4-hydroxy-4-methyloct-1-enyl]-5-oxocyclopentyl]heptanoate
INCHI	InChI=1S/C22H38O5/c1-4-5-14-22(2,26)15-10-12-18-17(19(23)16-20(18)24)11-8-6-7-9-13-21(25)27-3/h10,12,17-18,20,24,26H,4-9,11,13-16H2,1-3H3/b12-10+/t17-,18-,20-,22?/m1/s1
InChi Key	OJLOPKGSLYJEMD-URPKTTJQSA-N
Canonical SMILES	CCCCC(C)(CC=CC1C(CC(=O)C1CCCCCCC(=O)OC)O)O
分子式	C₂₂H₃₈O₅
PubChem CID	5282381
分子量	382.53

数据库链接

PubChem CID	5282381
Wikipedia	Misoprostol
ChEMBL Ligand	CHEMBL606
DrugBank Ligand	DB00929
CAS Registry No.	59122-46-2
ChEBI	CHEBI:63610
PEP	misoprostol
DrugCentral Ligand	1817
GPCRdb Ligand	misoprostol (methyl ester)

安全信息

象形图	Toxic Health Hazard
信号词	Danger
危险声明	H301: Toxic if swallowed H360: May damage fertility or the unborn child
预防措施声明	P301+P310,P201,P308+P313
WGK Germany	3

靶标

Target ID

341

名称

EP₂ receptor

缩写名

SHP2

家族

Prostanoid receptors

基因和蛋白信息

Species	Transmembrane Domains	Amino Acids	Chromosomal Location	Gene Symbol	Gene Name
Rat	7	357	15p14	Ptger2	prostaglandin E receptor 2
Human	7	358	14q22.1	PTGER2	prostaglandin E receptor 2
Mouse	7	362	14 22.68 cM	Ptger2	prostaglandin E receptor 2 (subtype EP2)

RefSeq Protein

NP_112350 (Rn) , NP_000947 (Hs) , NP_032990 (Mm)

UniProtKB

Q62928 (Rn) , P43116 (Hs) , Q62053 (Mm)

OMIM

176804 (Hs)

RefSeq Nucleotide

NM_000956 (Hs) , NM_031088 (Rn) , NM_008964 (Mm)

Entrez Gene

5732 (Hs) , 81752 (Rn) , 19217 (Mm)

Ensembl Gene

ENSG00000125384 (Hs) , ENSMUSG00000037759 (Mm) , ENSRNOG00000050968 (Rn)

Protein GI

13592031 (Rn) , 6679529 (Mm) , 31881630 (Hs)

dbSNP

rs17197 (Hs)

GPCRdb

pe2r2_human (Hs) , pe2r2_mouse (Mm) , pe2r2_rat (Rn)

UniProtKB ID/Entry name

PE2R2_HUMAN (Hs) , PE2R2_MOUSE (Mm) , PE2R2_RAT (Rn)

DrugBank Target

P43116 (Hs)

ChEMBL Target

CHEMBL1881 (Hs) , CHEMBL2488 (Mm) , CHEMBL4909 (Rn)

Target ID

342

名称

EP₃ receptor

缩写名

SHP2

家族

Prostanoid receptors

基因和蛋白信息

Species	Transmembrane Domains	Amino Acids	Chromosomal Location	Gene Symbol	Gene Name
Rat	7	365	2q45	Ptger3	prostaglandin E receptor 3
Human	7	390	1p31.1	PTGER3	prostaglandin E receptor 3
Mouse	7	365	3 81.32 cM	Ptger3	prostaglandin E receptor 3 (subtype EP3)

RefSeq Protein

NP_036836 (Rn) , NP_035326 (Mm) , NP_001119516 (Hs)

UniProtKB

P34980 (Rn) , P43115 (Hs) , P30557 (Mm)

OMIM

176806 (Hs)

RefSeq Nucleotide

NM_012704 (Rn) , NM_011196 (Mm) , NM_001126044 (Hs) , NM_198714 (Hs) , NM_198715 (Hs) , NM_198716 (Hs) , NM_198717 (Hs) , NM_198718 (Hs) , NM_198719 (Hs) , NR_028293 (Hs) , NR_028294 (Hs)

Entrez Gene

5733 (Hs) , 24929 (Rn) , 19218 (Mm)

Ensembl Gene

ENSG00000050628 (Hs) , ENSMUSG00000040016 (Mm) , ENSRNOG00000010325 (Rn)

Protein GI

6981434 (Rn) , 186659506 (Hs) , 86355516 (Mm)

GPCRdb

pe2r3_human (Hs) , pe2r3_mouse (Mm) , pe2r3_rat (Rn)

UniProtKB ID/Entry name

PE2R3_HUMAN (Hs) , PE2R3_MOUSE (Mm) , PE2R3_RAT (Rn)

DrugBank Target

P43115 (Hs)

ChEMBL Target

CHEMBL3710 (Hs) , CHEMBL4336 (Mm) , CHEMBL5674 (Rn)

Target ID

343

名称

EP₄ receptor

缩写名

SHP2

家族

Prostanoid receptors

基因和蛋白信息

Species	Transmembrane Domains	Amino Acids	Chromosomal Location	Gene Symbol	Gene Name
Rat	7	488	2q16	Ptger4	prostaglandin E receptor 4
Human	7	488	5p13.1	PTGER4	prostaglandin E receptor 4
Mouse	7	513	15 1.99 cM	Ptger4	prostaglandin E receptor 4 (subtype EP4)

RefSeq Protein

NP_114465 (Rn) , NP_000949 (Hs) , NP_032991 (Mm)

UniProtKB

P43114 (Rn) , P35408 (Hs) , P32240 (Mm)

OMIM

601586 (Hs)

RefSeq Nucleotide

NM_000958 (Hs) , NM_032076 (Rn) , NM_008965 (Mm)

Entrez Gene

5734 (Hs) , 84023 (Rn) , 19219 (Mm)

Ensembl Gene

ENSG00000171522 (Hs) , ENSMUSG00000039942 (Mm) , ENSRNOG00000013240 (Rn)

Protein GI

148747241 (Rn) , 209862967 (Mm) , 4506259 (Hs)

dbSNP

rs45613037 (Hs) , rs4613763 (Hs) , rs16869977 (Hs) , rs10512739 (Hs) , rs6880934 (Hs) , rs9292777 (Hs) , rs7725052 (Hs) , rs77145747 (Hs) , rs6896969 (Hs) , rs4613763 (Hs)

GPCRdb

pe2r4_human (Hs) , pe2r4_mouse (Mm) , pe2r4_rat (Rn)

UniProtKB ID/Entry name

PE2R4_HUMAN (Hs) , PE2R4_MOUSE (Mm) , PE2R4_RAT (Rn)

DrugBank Target

P35408 (Hs)

ChEMBL Target

CHEMBL2489 (Mm) , CHEMBL1836 (Hs) , CHEMBL4086 (Rn)

关联配体

Ligand ID	1936
名称	misoprostol (methyl ester)
别名	BRN 4155643
类别	Synthetic organic
学名	methyl 7-[(1R,2R,3R)-3-hydroxy-2-[(E)-4-hydroxy-4-methyloct-1-enyl]-5-oxocyclopentyl]heptanoate
生物活性评价	The sulfonamide class of antibacterial compounds are primarily bacteriostatic agents and have a broad spectrum of activity against both Gram-positive and Gram-negative species of bacteria (reviewed in ).
评价	The INN-assigned approved drug misoprostol is a racemic mixture of two epimers and their enantiomers. For more information, please see the ChEBI link above. Note that the INN-assigned structure represents the methyl ester form of the compound as which the drug is administered. The drug is then converted in vivo to the active metabolite .

参考文献

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2. Shu-Ping Hou,Ai-Hua Fang,Qin-Fang Chen,Yong-Mei Huang,Oiu-Ju Chen,Li-Nan Cheng. (2011-08-17) Termination of second-trimester pregnancy by mifepristone combined with misoprostol versus intra-amniotic injection of ethacridine lactate (Rivanol?): a systematic review of Chinese trials.. Contraception, 84 ((3)): (214-223). [PMID:21843683]
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