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400-620-6333
EP4 receptor
| Target Id | 343 |
|---|---|
| 缩写名 | SHP2 |
| 家族 | Prostanoid receptors |
基因和蛋白信息
数据库链接
| RefSeq Protein | NP_114465 (Rn) , NP_000949 (Hs) , NP_032991 (Mm) |
|---|---|
| UniProtKB | P43114 (Rn) , P35408 (Hs) , P32240 (Mm) |
| OMIM | 601586 (Hs) |
| RefSeq Nucleotide | NM_000958 (Hs) , NM_032076 (Rn) , NM_008965 (Mm) |
| Entrez Gene | 5734 (Hs) , 84023 (Rn) , 19219 (Mm) |
| Ensembl Gene | ENSG00000171522 (Hs) , ENSMUSG00000039942 (Mm) , ENSRNOG00000013240 (Rn) |
| Protein GI | 148747241 (Rn) , 209862967 (Mm) , 4506259 (Hs) |
| dbSNP | rs45613037 (Hs) , rs4613763 (Hs) , rs16869977 (Hs) , rs10512739 (Hs) , rs6880934 (Hs) , rs9292777 (Hs) , rs7725052 (Hs) , rs77145747 (Hs) , rs6896969 (Hs) , rs4613763 (Hs) |
| GPCRdb | pe2r4_human (Hs) , pe2r4_mouse (Mm) , pe2r4_rat (Rn) |
| UniProtKB ID/Entry name | PE2R4_HUMAN (Hs) , PE2R4_MOUSE (Mm) , PE2R4_RAT (Rn) |
| DrugBank Target | P35408 (Hs) |
| ChEMBL Target | CHEMBL2489 (Mm) , CHEMBL1836 (Hs) , CHEMBL4086 (Rn) |
作用于该靶标的配体
| Ligand Id | Ligand | Ligand Type | Action on Target | 对应产品货号 | 产品名称 |
|---|---|---|---|---|---|
| 1944 | 1-OH-PGE1 | Metabolite | Full agonist | O607091 | 1-OH-PGE? |
| 1925 | 11-deoxy-PGE1 | Metabolite | Full agonist | D334664 | 11-脱氧前列腺素E1 |
| 1925 | 11-deoxy-PGE1 | Metabolite | Full agonist | D334664 | 11-脱氧前列腺素E1 |
| 1945 | 11-deoxy-PGE2 | Synthetic organic | Full agonist | D356074 | 11-脱氧前列腺素E2 |
| 1946 | 13,14-dihydro-PGE1 | Metabolite | Full agonist | D274874 | 13,14-二氢前列腺素E1 |
| 1926 | 16,16-dimethyl-PGE2 | Metabolite | Full agonist | D275015 | 16,16-二甲基前列腺素 E2 |
| 1947 | 19(R)-OH-PGE2 | Metabolite | Full agonist | R607080 | 19(R)-OH-PGE? |
| 1913 | MB-28767 | Synthetic organic | Full agonist | M611751 | MB-28767 |
| 1913 | MB-28767 | Synthetic organic | Full agonist | M611751 | MB-28767 |
| 1913 | MB-28767 | Synthetic organic | Full agonist | M611751 | MB-28767 |
| 1930 | rivenprost | Synthetic organic | Full agonist | R613209 | rivenprost |
| 1933 | ONO-AE1-329 | Synthetic organic | Full agonist | O612526 | ONO-AE1-329 |
| 1881 | PGD2 | Metabolite | Full agonist | ||
| 1881 | PGD2 | Metabolite | Full agonist | ||
| 1882 | PGE1 | Natural product | Full agonist | P129960 | 前列腺素E1 |
| 1882 | PGE1 | Natural product | Full agonist | P129960 | 前列腺素E1 |
| 1882 | PGE1 | Natural product | Full agonist | P129960 | 前列腺素E1 |
| 1883 | PGE2 | Metabolite | Full agonist | D133402 | 地诺前列酮 |
| 1883 | PGE2 | Metabolite | Full agonist | D133402 | 地诺前列酮 |
| 1883 | PGE2 | Metabolite | Full agonist | D133402 | 地诺前列酮 |
| 1884 | PGF2α | Metabolite | Full agonist | T136386 | 前列腺素 |
| 1884 | PGF2α | Metabolite | Full agonist | T136386 | 前列腺素 |
| 1915 | PGI2 | Metabolite | Full agonist | P612776 | PGI? |
| 1888 | U46619 | Synthetic organic | Full agonist | U275847 | 9,11-二脱氧基-11α,9α-亚甲基环氧前列腺素 F2α |
| 1888 | U46619 | Synthetic organic | Full agonist | U275847 | 9,11-二脱氧基-11α,9α-亚甲基环氧前列腺素 F2α |
| 1916 | [3H]PGE2 | Synthetic organic | Full agonist | ||
| 1916 | [3H]PGE2 | Synthetic organic | Full agonist | ||
| 1892 | butaprost (free acid form) | Synthetic organic | Full agonist | B347295 | Butaprost，游离酸 |
| 1892 | butaprost (free acid form) | Synthetic organic | Full agonist | B347295 | Butaprost，游离酸 |
| 1893 | carbacyclin | Synthetic organic | Full agonist | C345266 | 碳环素（碳环PGI 2） |
| 1893 | carbacyclin | Synthetic organic | Full agonist | C345266 | 碳环素（碳环PGI 2） |
| 1917 | cicaprost | Synthetic organic | Full agonist | C337616 | 西卡前列素 |
| 1918 | enprostil | Synthetic organic | Full agonist | E610136 | enprostil |
| 1895 | iloprost | Synthetic organic | Full agonist | I275787 | 伊洛前列素 |
| 1895 | iloprost | Synthetic organic | Full agonist | I275787 | 伊洛前列素 |
| 1935 | misoprostol (free acid form) | Synthetic organic | Full agonist | ||
| 1936 | misoprostol (methyl ester) | Synthetic organic | Full agonist | M121725 | 米索前列醇 |
| 1949 | AH23848 | Synthetic organic | Antagonist | A338132 | AH 23848钙盐 |
| 1949 | AH23848 | Synthetic organic | Antagonist | A338132 | AH 23848钙盐 |
| 1950 | AH23848 (racemic) | Synthetic organic | Antagonist | A607468 | AH23848 (racemic) |
| 1949 | AH23848 | Synthetic organic | Antagonist | A338132 | AH 23848钙盐 |
| 1952 | L-161,982 (EP4A) | Synthetic organic | Agonist | L611372 | L-161,982 (EP?A) |
| 1952 | L-161,982 (EP4A) | Synthetic organic | Agonist | L611372 | L-161,982 (EP?A) |
| 1942 | ONO-AE3-208 | Synthetic organic | Antagonist | O125509 | ONO-AE3-208,性EP4拮抗剂 |
| 1929 | evatanepag | Synthetic organic | Antagonist | E610226 | evatanepag |
| 3380 | BGC201531 | Synthetic organic | Antagonist | B608034 | BGC201531 |
| 4039 | CP734432 | Synthetic organic | Full agonist | C609577 | CP734432 |
| 4040 | ER819762 | Synthetic organic | Antagonist | E288805 | ER 819762,EP4受体拮抗剂 |
| 4041 | MK-2894 | Synthetic organic | Antagonist | M127183 | MK-2894 |
| 1942 | ONO-AE3-208 | Synthetic organic | Antagonist | O125509 | ONO-AE3-208,性EP4拮抗剂 |
| 1883 | PGE2 | Metabolite | Full agonist | D133402 | 地诺前列酮 |
| 1882 | PGE1 | Natural product | Full agonist | P129960 | 前列腺素E1 |
| 3357 | L902688 | Synthetic organic | Agonist | L611430 | L902688 |
| 3357 | L902688 | Synthetic organic | Agonist | L611430 | L902688 |
| 1925 | 11-deoxy-PGE1 | Metabolite | Agonist | D334664 | 11-脱氧前列腺素E1 |
| 4039 | CP734432 | Synthetic organic | Agonist | C609577 | CP734432 |
| 1933 | ONO-AE1-329 | Synthetic organic | Full agonist | O612526 | ONO-AE1-329 |
| 1881 | PGD2 | Metabolite | Full agonist | ||
| 5820 | treprostinil | Synthetic organic | Agonist | T304716 | (停产)曲前列尼尔(瑞莫杜林) |
| 5820 | treprostinil | Synthetic organic | Agonist | T304716 | (停产)曲前列尼尔(瑞莫杜林) |
| 1895 | iloprost | Synthetic organic | Full agonist | I275787 | 伊洛前列素 |
| 1913 | MB-28767 | Synthetic organic | Full agonist | M611751 | MB-28767 |
| 1883 | PGE2 | Metabolite | Full agonist | D133402 | 地诺前列酮 |
| 5856 | MF 498 | Synthetic organic | Antagonist | M611851 | MF 498 |
| 5857 | CJ-042794 | Synthetic organic | Antagonist | C608576 | CJ-042794 |
| 5858 | grapiprant | Synthetic organic | Antagonist | G420030 | Grapiprant (CJ-023,423) |
| 1953 | GW 627368 | Synthetic organic | Antagonist | G288949 | GW 627368,EP4受体竞争性拮抗剂 |
| 5824 | ONO-AE2-227 | Synthetic organic | Antagonist | O612528 | ONO-AE2-227 |
| 1943 | ONO-AE3-240 | Synthetic organic | Antagonist | O612532 | ONO-AE3-240 |
| 4040 | ER819762 | Synthetic organic | Antagonist | E288805 | ER 819762,EP4受体拮抗剂 |
| 5859 | TCS 2510 | Synthetic organic | Agonist | C275241 | CAY10598,EP 4激动剂 |
| 1884 | PGF2α | Metabolite | Full agonist | T136386 | 前列腺素 |
| 5860 | THG213.29 | Peptide | Negative | rp175281 | THG213.29 |
| 8541 | ONO-AE1-437 | Synthetic organic | Agonist | O612527 | ONO-AE1-437 |
| 9283 | TG6-129 | Synthetic organic | Antagonist | T614407 | TG6-129 |
| 5852 | MRE-269 | Synthetic organic | Agonist | M413342 | MRE-269 (ACT-333679) |
| 1967 | beraprost | Synthetic organic | Agonist | B608001 | beraprost |
| 9845 | CR6086 | Synthetic organic | Antagonist | C609596 | CR6086 |
| 9845 | CR6086 | Synthetic organic | Antagonist | C609596 | CR6086 |
| 9845 | CR6086 | Synthetic organic | Antagonist | C609596 | CR6086 |
| 9845 | CR6086 | Synthetic organic | Antagonist | C609596 | CR6086 |
| 1912 | 17-phenyl-ω-trinor-PGE2 | Metabolite | Agonist | P336631 | 17-苯基-18,19,20-三去甲前列腺素 E? |
| 10603 | TG11-77 | Synthetic organic | Antagonist | T614405 | TG11-77 |
| 12017 | compound 47 [PMID: 35640059] | Synthetic organic | Antagonist | F609239 | 4-[[[2-[(4-fluorophenyl)methyl]-5,7-dihydro-4H-thieno[2,3-c]pyran-3-carbonyl]amino]methyl]benzoic acid |
| 12521 | KMN-159 | Synthetic organic | Agonist | K611348 | KMN-159 |
| 12521 | KMN-159 | Synthetic organic | Agonist | K611348 | KMN-159 |
危险品化学品经营许可证（带存储）