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长春花碱

规格或纯度: 98%

CAS编号: 865-21-4
分子式: C₄₆H₅₈N₄O₉
分子量: 810.97
PubChem编号: 13342

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货号 (SKU)	包装规格	是否现货
V127032-10mg	10mg	现货
V127032-20mg	20mg	现货
V127032-50mg	50mg	现货
V127032-250mg	250mg	现货

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tubulin beta class I Inhibitor

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基本描述

规格或纯度	98%
英文名称	Vinblastine
别名	长春花碱
英文别名	Vincaleukoblastine, Velban, Velsar;1H-Indolizino[8,1-cd]carbazole-5-carboxylic acid,4-(acetyloxy)-3a-ethyl-9-[5-ethyl-1,4,5,6,7,8,9,10-octahydro-5-hydroxy-9-(methoxycarbonyl)-2H-3,7-methanoazacycloundecino[5,4-b]indol-9-yl]-3a,4,5,5a,6,11,12,13a-octahydro
生化机理	Vinblastine does not interfere with phrenic nerve stimulation of rat diaphragm musculature in concentrations up to 200 microM. However, in relatively high doses, vinblastine (10-200 microM) produces an increase in baseline tension of diaphragm muscle. This effect is concentration related (EC50, approximately 88 microM), reversible, and independent of phrenic nerve stimulation. The elevation in baseline tension is unaffected by nAChR blockade via d-tubocurarine, but is dependent upon the presence of extracellular calcium. In human Burkitt lymphoma CA46 cells, vinblastine (IC50 values, 1.0 nM). It binds tubulin, thereby inhibiting the assembly of microtubules.It is used to treat certain kinds of cancer, including Hodgkin
储存温度	-20°C储存
运输条件	超低温冰袋运输
产品介绍	Vinblastine抑制微管形成，抑制nAChR活性，IC50为8.9 μM。 Vinblastine inhibits microtubule formation and supresses nAChR activity with IC50 of 8.9 μM.

名称和标识符

IUPAC Name	methyl (1R,9R,10S,11R,12R,19R)-11-acetyloxy-12-ethyl-4-[(13S,15R,17S)-17-ethyl-17-hydroxy-13-methoxycarbonyl-1,11-diazatetracyclo[13.3.1.04,12.05,10]nonadeca-4(12),5,7,9-tetraen-13-yl]-10-hydroxy-5-methoxy-8-methyl-8,16-diazapentacyclo[10.6.1.01,9.02,7.016,19]nonadeca-2,4,6,13-tetraene-10-carboxylate
INCHI	InChI=1S/C46H58N4O9/c1-8-42(54)23-28-24-45(40(52)57-6,36-30(15-19-49(25-28)26-42)29-13-10-11-14-33(29)47-36)32-21-31-34(22-35(32)56-5)48(4)38-44(31)17-20-50-18-12-16-43(9-2,37(44)50)39(59-27(3)51)46(38,55)41(53)58-7/h10-14,16,21-22,28,37-39,47,54-55H,8-9,15,17-20,23-26H2,1-7H3/t28-,37-,38+,39+,42-,43+,44+,45-,46-/m0/s1
InChi Key	JXLYSJRDGCGARV-CFWMRBGOSA-N
Canonical SMILES	CCC1(CC2CC(C3=C(CCN(C2)C1)C4=CC=CC=C4N3)(C5=C(C=C6C(=C5)C78CCN9C7C(C=CC9)(C(C(C8N6C)(C(=O)OC)O)OC(=O)C)CC)OC)C(=O)OC)O
分子式	C₄₆H₅₈N₄O₉
PubChem CID	13342
分子量	810.97

数据库链接

DrugBank Ligand	DB00570
PubChem CID	13342
CAS Registry No.	865-21-4
ChEMBL Ligand	CHEMBL159
Wikipedia	Vinblastine
ChEBI	CHEBI:27375
RCSB PDB Ligand	VLB
PEP	vinblastine
DrugCentral Ligand	2823

化学和物理性质

溶解性	25°C: DMSO 67 mg/mL; Water <1 mg/mL; Ethanol 7 mg/mL

靶标

Target ID

2640

名称

tubulin beta class I

缩写名

SHP2

家族

Tubulins

基因和蛋白信息

Species	Transmembrane Domains	Amino Acids	Chromosomal Location	Gene Symbol	Gene Name
Human	2	444	6p21.33	TUBB	tubulin beta class I
Mouse	2	444	17 B1	Tubb5	tubulin, beta 5 class I
Rat	2	444	20p12	Tubb5	tubulin, beta 5 class I

Entrez Gene

203068 (Hs) , 22154 (Mm) , 29214 (Rn)

UniProtKB

P99024 (Mm) , P07437 (Hs) , P69897 (Rn)

Ensembl Gene

ENSG00000196230 (Hs) , ENSMUSG00000001525 (Mm) , ENSRNOG00000061216 (Rn)

RefSeq Nucleotide

NM_011655 (Mm) , NM_178014 (Hs) , NM_173102 (Rn)

RefSeq Protein

NP_035785 (Mm) , NP_821133 (Hs) , NP_775125 (Rn)

OMIM

191130 (Hs)

Protein GI

29788785 (Hs) , 7106439 (Mm) , 27465535 (Rn)

DrugBank Target

P07437 (Hs)

CATH/Gene3D

3.30.1330.20 (N/A) , 3.40.50.1440 (N/A)

ChEMBL Target

CHEMBL4739682 (Mm) , CHEMBL5444 (Hs)

关联配体

Ligand ID	6851
名称	vinblastine
别名	29060-LE
类别	Synthetic organic
学名	4-amino-N-(4,6-dimethylpyrimidin-2-yl)benzenesulfonamide
生物活性评价	The sulfonamide class of antibacterial compounds are primarily bacteriostatic agents and have a broad spectrum of activity against both Gram-positive and Gram-negative species of bacteria (reviewed in ).
评价	A pan tubulin inhibitor. A chemical analogue of (from Catharanthus roseus, also known as Vinca rosea). There is some ambiguity surrounding the exact stereochemistry of vinblastine. The chirality shown here corresponds to the PubChem entry linked to in the table above. However, bioactivity data for the compound is also listed against CID 241903, and some of the links in the table above refer to this chiral specification or others. Marketed formulations contain vinblastine sulfate (PubChem CID 5388983).