T0901317,非LXR激动剂

强大的非选择性LXR激动剂

规格或纯度: ≥98%

CAS编号: 293754-55-9
分子式: C₁₇H₁₂F₉NO₃S
分子量: 481.33
MDL号: MFCD03412028
PubChem编号: 447912

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库存信息

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货号 (SKU)	包装规格	是否现货	价格	数量
T129709-25mg	25mg	现货
T129709-100mg	100mg	期货

查看相关系列

Liver X receptor-α Agonist Liver X receptor-β Agonist RAR-related orphan receptor-α Agonist RAR-related orphan receptor-γ Agonist

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基本描述

规格或纯度	≥98%
英文名称	T0901317
别名	T 0901317; T-0901317
英文别名	T 0901317; T-0901317; N-(2,2,2-Trifluoroethyl)-N-[4-[2,2,2-trifluoro-1-hydroxy-1-(trifluoromethyl)ethyl]phenyl]benzenesulfonamide;N-[4-(1,1,1,3,3,3-hexafluoro-2-hydroxypropan-2-yl)phenyl]-N-(2,2, 2-trifluoroethyl)benzenesulfonamide;
生化机理	T 0901317 is a cell-permeable, nonsterol, benzenesulfonamide compound that acts as a highly selective and potent liver X receptor (LXR) agonist (EC50 of 20 nM for LXRα). T 0901317 is reported to induce the expression of genes associated with fatty acid biosynthesis and raise both the levels of serum HDL cholesterol and triglyceride.Potent, non-selective LXR agonist (EC 50 = 50 nM). Increases ABCA1 expression associated with cholesterol efflux regulation and HDL metabolism. Increases muscle expression of PPAR-δ. Shows antiobesogenic effects in vivo.
储存温度	-20°C储存
运输条件	超低温冰袋运输
备注	如果有可能，您尽量在使用的当天配置溶液，并在当天使用完它。但是，如果您需要预先配制储备溶液，我们建议您将溶液等份保存在-20°C的密封小瓶中。通常，它们最多可以使用一个月。在使用前和打开样品瓶之前，我们建议您让您的产品在室温下平衡至少1小时。需要更多关于溶解度，用法和处理的建议吗？请访问我们的常见问题（FAQ）页面以获取更多详细信息。
产品介绍	T0901317是一个强的和选择性的LXR和FXR激动剂，EC50分别是50 nM和5 μM，能够抑制核里的NF/κB。A cell-permeable, nonsterol compound that acts as a highly potent LXR activator T0901317 is a potent and selective agonist for both LXR and FXR, with EC50 of ~50 nM and 5 μM, respectively. A cell-permeable, nonsterol compound that acts as a highly potent LXR activator

名称和标识符

IUPAC Name	N-[4-(1,1,1,3,3,3-hexafluoro-2-hydroxypropan-2-yl)phenyl]-N-(2,2,2-trifluoroethyl)benzenesulfonamide
INCHI	InChI=1S/C17H12F9NO3S/c18-14(19,20)10-27(31(29,30)13-4-2-1-3-5-13)12-8-6-11(7-9-12)15(28,16(21,22)23)17(24,25)26/h1-9,28H,10H2
InChi Key	SGIWFELWJPNFDH-UHFFFAOYSA-N
Canonical SMILES	C1=CC=C(C=C1)S(=O)(=O)N(CC(F)(F)F)C2=CC=C(C=C2)C(C(F)(F)F)(C(F)(F)F)O
分子式	C₁₇H₁₂F₉NO₃S
关联CAS	293754-55-9
UNII	A07663A39I
PubChem CID	447912
分子量	481.33

化学和物理性质

溶解性	DMSO 96 mg/mL Water <1 mg/mL Ethanol 96 mg/mL
密度	1.55
沸点	470.55° C at 760 mmHg
熔点	116-122°C
折光率	1.49

靶标

Target ID

598

名称

RAR-related orphan receptor-α

缩写名

SHP2

家族

1F. Retinoic acid-related orphans

基因和蛋白信息

Species	Transmembrane Domains	Amino Acids	Chromosomal Location	Gene Symbol	Gene Name
Human	2	523	15q22.2	RORA	RAR related orphan receptor A
Mouse	2	523	9 37.45 cM	Rora	RAR-related orphan receptor alpha
Rat	2	309	8q24	Rora	RAR-related orphan receptor A

Entrez Gene

6095 (Hs) , 19883 (Mm) , 300807 (Rn)

OMIM

600825 (Hs)

UniProtKB

P35398 (Hs) , P51448 (Mm)

RefSeq Nucleotide

NM_134260 (Hs) , NM_013646 (Mm)

RefSeq Protein

NP_599023 (Hs) , NP_038674 (Mm) , NP_599022 (Hs) , NP_002934 (Hs) , NP_599024 (Hs)

Ensembl Gene

ENSG00000069667 (Hs) , ENSMUSG00000032238 (Mm) , ENSRNOG00000027145 (Rn)

Protein GI

7305439 (Mm) , 19743905 (Hs)

NURSA Receptor

10.1621/DSPDOWHBAX (Hs)

CATH/Gene3D

3.30.50.10 (N/A)

ChEMBL Target

CHEMBL5868 (Hs) , CHEMBL3217403 (Mm)

Target ID

600

名称

RAR-related orphan receptor-γ

缩写名

SHP2

家族

1F. Retinoic acid-related orphans

基因和蛋白信息

Species	Transmembrane Domains	Amino Acids	Chromosomal Location	Gene Symbol	Gene Name
Human	2	518	1q21	RORC	RAR related orphan receptor C
Mouse	2	516	3 F2.1	Rorc	RAR-related orphan receptor gamma
Rat	2	147	2q34	Rorc	RAR-related orphan receptor C

Entrez Gene

6097 (Hs) , 19885 (Mm) , 368158 (Rn)

OMIM

602943 (Hs)

UniProtKB

P51449 (Hs) , P51450 (Mm)

RefSeq Nucleotide

NM_001001523 (Hs) , NM_011281 (Mm) , NM_005060 (Hs)

RefSeq Protein

NP_005051 (Hs) , NP_035411 (Mm) , NP_001001523 (Hs)

Ensembl Gene

ENSG00000143365 (Hs) , ENSMUSG00000028150 (Mm) , ENSRNOG00000020836 (Rn)

Protein GI

48255918 (Hs) , 188536040 (Mm) , 109467161 (Rn)

NURSA Receptor

10.1621/SQN2V3ZKEV (Hs)

CATH/Gene3D

3.30.50.10 (N/A)

ChEMBL Target

CHEMBL1741186 (Hs) , CHEMBL1293231 (Mm)

Target ID

601

名称

Liver X receptor-β

缩写名

SHP2

家族

1H. Liver X receptor-like receptors

基因和蛋白信息

Species	Transmembrane Domains	Amino Acids	Chromosomal Location	Gene Symbol	Gene Name
Human	2	460	19q13.3	NR1H2	nuclear receptor subfamily 1 group H member 2
Mouse	2	446	7 B3	Nr1h2	nuclear receptor subfamily 1, group H, member 2
Rat	2	446	1q22	Nr1h2	nuclear receptor subfamily 1, group H, member 2

Entrez Gene

7376 (Hs) , 58851 (Rn) , 22260 (Mm)

OMIM

600380 (Hs)

UniProtKB

P55055 (Hs) , Q62755 (Rn) , Q60644 (Mm)

RefSeq Nucleotide

NM_007121 (Hs) , NM_031626 (Rn) , NM_009473 (Mm)

RefSeq Protein

NP_009052 (Hs) , NP_033499 (Mm) , NP_113814 (Rn)

Ensembl Gene

ENSG00000131408 (Hs) , ENSMUSG00000060601 (Mm) , ENSRNOG00000019812 (Rn)

Protein GI

375331888 (Hs) , 13928862 (Rn) , 6678507 (Mm)

NURSA Receptor

10.1621/4Y2DTEP5D8 (Hs)

CATH/Gene3D

3.30.50.10 (N/A)

ChEMBL Target

CHEMBL4105785 (Rn) , CHEMBL2417346 (Mm) , CHEMBL4093 (Hs)

Target ID

602

名称

Liver X receptor-α

缩写名

SHP2

家族

1H. Liver X receptor-like receptors

基因和蛋白信息

Species	Transmembrane Domains	Amino Acids	Chromosomal Location	Gene Symbol	Gene Name
Human	2	447	11p11.2	NR1H3	nuclear receptor subfamily 1 group H member 3
Mouse	2	445	2 50.52 cM	Nr1h3	nuclear receptor subfamily 1, group H, member 3
Rat	2	445	3q24	Nr1h3	nuclear receptor subfamily 1, group H, member 3

Entrez Gene

10062 (Hs) , 22259 (Mm) , 58852 (Rn)

OMIM

602423 (Hs)

UniProtKB

Q13133 (Hs) , Q62685 (Rn) , Q9Z0Y9 (Mm)

RefSeq Nucleotide

NM_001130102 (Hs) , NM_031627 (Rn) , NM_013839 (Mm) , NM_001177730 (Mm)

RefSeq Protein

NP_005684 (Hs) , NP_038867 (Mm) , NP_113815 (Rn)

Ensembl Gene

ENSG00000025434 (Hs) , ENSMUSG00000002108 (Mm) , ENSRNOG00000013172 (Rn)

Orphanet

123908 (Hs)

Protein GI

295148193 (Mm) , 353731060 (Hs) , 145279192 (Rn)

NURSA Receptor

10.1621/WD46UVPRKT (Hs)

CATH/Gene3D

3.30.50.10 (N/A)

ChEMBL Target

CHEMBL2808 (Hs) , CHEMBL2189152 (Mm) , CHEMBL4523336 (Rn)

关联配体

Ligand ID	2755
名称	T0901317
别名	T-0901317
类别	Synthetic organic
学名	N-[4-(1,1,1,3,3,3-hexafluoro-2-hydroxypropan-2-yl)phenyl]-N-(2,2,2-trifluoroethyl)benzenesulfonamide
生物活性评价	The sulfonamide class of antibacterial compounds are primarily bacteriostatic agents and have a broad spectrum of activity against both Gram-positive and Gram-negative species of bacteria (reviewed in ).
评价	T0901317 is a synthetic agonist of the liver X receptors (LXRs), equipotent at the α and β receptor isoforms. T0901317-induced repression of the gluconeogenic enzyme glucose-6-phosphatase is is ROR-dependent and is not associated with the ligand's LXR activity .

参考文献

1. Han S, Zhuang H, Shumyak S, Wu J, Xie C, Li H, Yang LJ, Reeves WH. (2018) Liver X Receptor Agonist Therapy Prevents Diffuse Alveolar Hemorrhage in Murine Lupus by Repolarizing Macrophages.. Front Immunol, 9 (13): (135). [PMID:29456535]
2. Wang J, Xiao C, Wei Z, Wang Y, Zhang X, Fu Y. (2018) Activation of liver X receptors inhibit LPS-induced inflammatory response in primary bovine mammary epithelial cells.. Vet Immunol Immunopathol, 197 (13): (87-92). [PMID:29475512]
3. Zhang CJ et al.. (2021) Celastrol induces lipophagy via the LXRα/ABCA1 pathway in clear cell renal cell carcinoma.. Acta Pharmacol Sin, 42 (9): (1472-1485). [PMID:33303989]
4. Wu D et al.. (2021) Dichlorodiphenyltrichloroethane Impairs Amyloid Beta Clearance by Decreasing Liver X Receptor a Expression.. Front Aging Neurosci, 13 (): (634948). [PMID:34045954]

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T0901317,非LXR激动剂

库存信息

库存信息

基本描述

名称和标识符

化学和物理性质

靶标

关联配体

参考文献

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T0901317,非LXR激动剂

库存信息

库存信息

基本描述

名称和标识符

化学和物理性质

靶标

关联配体

参考文献

相关文档

质检报告COA

产品问答

产品问答

91高清自产国产拍,无码免费A级毛片大全,日本 欧美 国产中文字幕,99re热视频这里只有精品视频首页

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