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亚精胺

规格或纯度: 99%

CAS编号: 124-20-9
分子式: C₇H₁₉N₃
分子量: 145.25
Beilstein号: 1698591
EC号: 204-689-0
MDL号: MFCD00008229
PubChem编号: 1102

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货号 (SKU)	包装规格	是否现货
S107071-1g	1g	现货
S107071-5g	5g	现货
S107071-25g	25g	现货
S107071-100g	100g	现货

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Kir2.1 Channel blocker Kir2.3 Channel blocker

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基本描述

规格或纯度	99%
英文名称	Spermidine
别名	精脒；N-(3-氨基丙基)-1,4-丁烷；1,8-二氨基-4-氮杂辛烷
英文别名	N-(3-Aminopropyl)-1,4-diaminobutane;1,8-Diamino-4-azaoctane
应用	抑制神经元NO合成酶(nNOS)。结合并沉淀DNA; 也用于纯化DNA结合蛋白。刺激T4 聚核苷酸激酶活性。
储存温度	2-8°C储存,充氩
运输条件	冰袋运输
产品介绍	溶于水、醇和醚。抑制神经元NO合成酶(nNOS)。结合并沉淀DNA; 也用于纯化DNA结合蛋白。刺激T4 聚核苷酸激酶活性。 Inhibits neuronal nitric oxide synthase (nNOS). Binds and precipitates DNA; may be used for purification of DNA binding proteins. Stimulates T4 polynucleotide kinase activity.

名称和标识符

EC号	204-689-0
IUPAC Name	N'-(3-aminopropyl)butane-1,4-diamine
INCHI	InChI=1S/C7H19N3/c8-4-1-2-6-10-7-3-5-9/h10H,1-9H2
InChi Key	ATHGHQPFGPMSJY-UHFFFAOYSA-N
Canonical SMILES	C(CCNCCCN)CN
分子式	C₇H₁₉N₃
UN Number	2735
PubChem CID	1102
Beilstein号	1698591
分子量	145.25

化学和物理性质

溶解性	Miscible with water, ethanol and ether.
密度	0.925
敏感性	对空气和湿度敏感 ;易吸湿
沸点	128-130°C
熔点	22-25°C
折光率	1.4785-1.4805
闪点(℉)	230°F
闪点(℃)	>110°

安全信息

象形图	Corrosive
信号词	Danger
危险声明	H314: Causes severe skin burns and eye damage H318: Causes serious eye damage
预防措施声明	P280,P321,P405,P501,P264,P260,P301+P330+P331,P304+P340,P363,P264+P265,P305+P354+P338,P317,P302+P361+P354,P316
WGK Germany	3
个人防护装备	Faceshields,Gloves,Goggles

靶标

Target ID

430

名称

K_ir2.1

缩写名

SHP2

家族

Inwardly rectifying potassium channels (K_IR)

别名

MCP-1 receptor

基因和蛋白信息

Species	Transmembrane Domains	Amino Acids	Chromosomal Location	Gene Symbol	Gene Name
Human	2	427	17q24.3	KCNJ2	potassium inwardly rectifying channel subfamily J member 2
Rat	2	427	10q32.1	Kcnj2	potassium inwardly-rectifying channel, subfamily J, member 2
Mouse	2	428	11 75.23 cM	Kcnj2	potassium inwardly-rectifying channel, subfamily J, member 2

OMIM

600681 (Hs)

Entrez Gene

16518 (Mm) , 29712 (Rn) , 3759 (Hs)

UniProtKB

Q64273 (Rn) , P35561 (Mm) , P63252 (Hs)

RefSeq Protein

NP_000882 (Hs) , NP_058992 (Rn) , NP_032451 (Mm)

RefSeq Nucleotide

NM_000891 (Hs) , NM_017296 (Rn) , NM_008425 (Mm)

Ensembl Gene

ENSG00000123700 (Hs) , ENSMUSG00000041695 (Mm) , ENSRNOG00000064933 (Rn)

Orphanet

122791 (Hs)

Protein GI

8393652 (Rn) , 4504835 (Hs) , 6680530 (Mm)

CATH/Gene3D

2.60.40.1400 (N/A)

ChEMBL Target

CHEMBL1914276 (Hs) , CHEMBL1293290 (Mm)

Target ID

432

名称

K_ir2.3

缩写名

SHP2

家族

Inwardly rectifying potassium channels (K_IR)

别名

MCP-1 receptor

基因和蛋白信息

Species	Transmembrane Domains	Amino Acids	Chromosomal Location	Gene Symbol	Gene Name
Human	2	445	22q13.1	KCNJ4	potassium inwardly rectifying channel subfamily J member 4
Rat	2	446	7q34	Kcnj4	potassium inwardly-rectifying channel, subfamily J, member 4
Mouse	2	445	15 37.74 cM	Kcnj4	potassium inwardly-rectifying channel, subfamily J, member 4

OMIM

600504 (Hs)

Entrez Gene

116649 (Rn) , 16520 (Mm) , 3761 (Hs)

UniProtKB

P52189 (Mm) , P52190 (Rn) , P48050 (Hs)

RefSeq Protein

NP_690607 (Hs) , NP_446322 (Rn) , NP_032453 (Mm)

RefSeq Nucleotide

NM_152868 (Hs) , NM_053870 (Rn) , NM_008427 (Mm)

Ensembl Gene

ENSG00000168135 (Hs) , ENSMUSG00000044216 (Mm) , ENSRNOG00000013869 (Rn)

Protein GI

158711668 (Mm) , 23110984 (Hs) , 76881824 (Rn)

CATH/Gene3D

2.60.40.1400 (N/A)

ChEMBL Target

CHEMBL2146347 (Hs)

关联配体

Ligand ID	2390
名称	spermidine
类别	Metabolite
学名	N-(3-aminopropyl)butane-1,4-diamine
生物活性评价	The sulfonamide class of antibacterial compounds are primarily bacteriostatic agents and have a broad spectrum of activity against both Gram-positive and Gram-negative species of bacteria (reviewed in ).
评价	Sulfadimidine (sulfamethazine) is a sulfonamide antibacterial compound. This class of compounds are competitive inhibitors of bacterial dihydropteroate synthase (DHPS), an enzyme in the pathway which generates the folic acid that is essential for bacterial growth.