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tumour necrosis factor membrane form
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基本描述
| 产品名称 | tumour necrosis factor membrane form |
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产品规格参数
| CAS编号和信息 | rp175335 |
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数据库链接
| UniProtKB | P01375 |
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| Wikipedia | Tumor_necrosis_factor-alpha |
| RCSB PDB Structure | 1TNF |
| Ensembl Gene | ENSG00000204490 |
| DrugBank Target | P01375 |
| CATH/Gene3D | 2.60.120.40 |
靶标
| Target ID | 1870 | ||||||||||||||||||||||||
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| 名称 | tumor necrosis factor receptor 1 | ||||||||||||||||||||||||
| 缩写名 | TNFR1 | ||||||||||||||||||||||||
| 家族 | Tumour necrosis factor (TNF) receptor family | ||||||||||||||||||||||||
| 基因和蛋白信息 |
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| Ensembl Gene | ENSG00000067182 (Hs) , ENSMUSG00000030341 (Mm) , ENSRNOG00000031312 (Rn) | ||||||||||||||||||||||||
| Entrez Gene | 21937 (Mm) , 25625 (Rn) , 7132 (Hs) | ||||||||||||||||||||||||
| OMIM | 191190 (Hs) | ||||||||||||||||||||||||
| Protein GI | 4507575 (Hs) , 31560799 (Mm) , 6981664 (Rn) | ||||||||||||||||||||||||
| UniProtKB | P19438 (Hs) , P25118 (Mm) , P22934 (Rn) | ||||||||||||||||||||||||
| ChEMBL Target | CHEMBL3378 (Hs) |
| Target ID | 1871 | ||||||||||||||||||||||||
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| 名称 | tumor necrosis factor receptor 2 | ||||||||||||||||||||||||
| 缩写名 | TNFR2 | ||||||||||||||||||||||||
| 家族 | Tumour necrosis factor (TNF) receptor family | ||||||||||||||||||||||||
| 基因和蛋白信息 |
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| Ensembl Gene | ENSG00000028137 (Hs) , ENSMUSG00000028599 (Mm) , ENSRNOG00000016575 (Rn) | ||||||||||||||||||||||||
| Entrez Gene | 21938 (Mm) , 156767 (Rn) , 7133 (Hs) | ||||||||||||||||||||||||
| OMIM | 191191 (Hs) | ||||||||||||||||||||||||
| Protein GI | 30794230 (Rn) , 70778792 (Mm) , 4507577 (Hs) | ||||||||||||||||||||||||
| UniProtKB | P20333 (Hs) , P25119 (Mm) , Q80WY6 (Rn) | ||||||||||||||||||||||||
| ChEMBL Target | CHEMBL1250356 (Hs) |
关联配体
| Ligand ID | 5073 | ||||||||||
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| 名称 | tumour necrosis factor membrane form | ||||||||||
| 别名 | TNFα | ||||||||||
| 类别 | Peptide | ||||||||||
| 学名 | 4-amino-N-(4,6-dimethylpyrimidin-2-yl)benzenesulfonamide | ||||||||||
| 生物活性评价 |
The sulfonamide class of antibacterial compounds are primarily bacteriostatic agents and have a broad spectrum of activity against both Gram-positive and Gram-negative species of bacteria (reviewed in |
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| 评价 |
TNFα is a pro-inflammatory, acute phase cytokine involved in systemic inflammation. The TNFSF2 precursor is also cleaved into a membrane-bound form of the ligand. |
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| 配体家族 | Tumor necrosis factor superfamily ligands | ||||||||||
| 基因/前体 |
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| 单字母多肽序列 | MSTESMIRDVELAEEALPKKTGGPQGSRRCLFLSLFSFLIVAGATTLFCLLHFGVIGPQREEFPRDLSLISPLAQAVRSSSRTPSDKPVAHVVANPQAEGQLQWLNRRANALLANGVELRDNQLVVPSEGLYLIYSQVLFKGQGCPSTHVLLTHTISRIAVSYQTKVNLLSAIKSPCQRETPEGAEAKPWYEPIYLGGVFQLEKGDRLSAEINRPDYLDFAESGQVYFGIIAL | ||||||||||
| 三字母多肽序列 | |||||||||||
| 翻译后修饰 | Predicted phosphorylation of serine residue at position 2; residues 19 and 20 are N6-myristoyl lysine | ||||||||||
| 化学修饰 |
参考文献
| 1. Crowe JS, Roberts KJ, Carlton TM, Maggiore L, Cubitt MF, Clare S, Harcourt K, Reckless J, MacDonald TT, Ray KP et al.. (2018) Preclinical Development of a Novel, Orally-Administered Anti-Tumour Necrosis Factor Domain Antibody for the Treatment of Inflammatory Bowel Disease.. Sci Rep, 8 (1): (4941). [PMID:29563546] |
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