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tumour necrosis factor membrane form

别名 TNFα, cachectin, necrosin
Compound Class Peptide
变动原因 TNFα is a pro-inflammatory, acute phase cytokine involved in systemic inflammation.
The TNFSF2 precursor is also cleaved into a membrane-bound form of the ligand.
Species Human
Related Product tumour necrosis factor membrane form

Summary

基因/前体
Gene symbol Gene name Precursor protein name Species 别名
TNF tumor necrosis factor prepro-tumor necrosis factor Human TNFA, TNFSF2, DIF, TNF-alpha, tumor necrosis factor (TNF superfamily, member 2), TNF superfamily, member 2
是否批准为药物？
IUPAC Name 4-amino-N-(4,6-dimethylpyrimidin-2-yl)benzenesulfonamide
别名 TNFα, cachectin, necrosin

生物活性

生物活性评价 The sulfonamide class of antibacterial compounds are primarily bacteriostatic agents and have a broad spectrum of activity against both Gram-positive and Gram-negative species of bacteria (reviewed in ).
关联靶标 tumor necrosis factor receptor 1 , tumor necrosis factor receptor 2

临床资料

作用机制与药效学效应 Sulfonamides are structural analogues of 4-aminobenzoic acid (pABA) an intermediate in the de novo synthesis of folate by some prokaryotes, lower eukaryotes and plants . The antibacterial MMOA is competitive inhibition of bacterial dihydropteroate synthase (DHPS) resulting in a block of folate biosynthesis .

参考文献

1. Crowe JS, Roberts KJ, Carlton TM, Maggiore L, Cubitt MF, Clare S, Harcourt K, Reckless J, MacDonald TT, Ray KP et al..  (2018)  Preclinical Development of a Novel, Orally-Administered Anti-Tumour Necrosis Factor Domain Antibody for the Treatment of Inflammatory Bowel Disease..  Sci Rep,  8  (1):  (4941).  [PMID:29563546]

结构

Peptide Sequence MSTESMIRDVELAEEALPKKTGGPQGSRRCLFLSLFSFLIVAGATTLFCLLHFGVIGPQREEFPRDLSLISPLAQAVRSSSRTPSDKPVAHVVANPQAEGQLQWLNRRANALLANGVELRDNQLVVPSEGLYLIYSQVLFKGQGCPSTHVLLTHTISRIAVSYQTKVNLLSAIKSPCQRETPEGAEAKPWYEPIYLGGVFQLEKGDRLSAEINRPDYLDFAESGQVYFGIIAL
Post Translation Modifications Predicted phosphorylation of serine residue at position 2; residues 19 and 20 are N6-myristoyl lysine
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