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TL6
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基本描述
| 产品名称 | TL6 |
|---|
产品规格参数
| CAS编号和信息 | rp175309 |
|---|
数据库链接
| UniProtKB | Q9UNG2 |
|---|---|
| Wikipedia | TNFSF18 |
| RCSB PDB Structure | 2Q1M |
| Ensembl Gene | ENSG00000120337 |
| CATH/Gene3D | 2.60.120.40 |
靶标
| Target ID | 1890 | ||||||||||||||||||||||||
|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|
| 名称 | glucocorticoid-induced TNF receptor | ||||||||||||||||||||||||
| 缩写名 | GITR | ||||||||||||||||||||||||
| 家族 | Tumour necrosis factor (TNF) receptor family | ||||||||||||||||||||||||
| 基因和蛋白信息 |
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| Ensembl Gene | ENSG00000186891 (Hs) , ENSMUSG00000041954 (Mm) , ENSRNOG00000022012 (Rn) | ||||||||||||||||||||||||
| Entrez Gene | 21936 (Mm) , 500598 (Rn) , 8784 (Hs) | ||||||||||||||||||||||||
| OMIM | 603905 (Hs) | ||||||||||||||||||||||||
| Protein GI | 11464977 (Mm) , 23238197 (Hs) , 66730495 (Rn) | ||||||||||||||||||||||||
| UniProtKB | Q9Y5U5 (Hs) , O35714 (Mm) | ||||||||||||||||||||||||
| ChEMBL Target | CHEMBL3712995 (Hs) |
关联配体
| Ligand ID | 5072 | ||||||||||
|---|---|---|---|---|---|---|---|---|---|---|---|
| 名称 | TL6 | ||||||||||
| 别名 | glucocorticoid- induced TNF-related ligand | ||||||||||
| 类别 | Peptide | ||||||||||
| 学名 | 4-amino-N-(4,6-dimethylpyrimidin-2-yl)benzenesulfonamide | ||||||||||
| 生物活性评价 |
The sulfonamide class of antibacterial compounds are primarily bacteriostatic agents and have a broad spectrum of activity against both Gram-positive and Gram-negative species of bacteria (reviewed in |
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| 评价 | TL6 (official name, tumor necrosis factor ligand superfamily member 18) is a cytokine belonging to the tumor necrosis factor (TNF) ligand family. It is thought to be involved in T cell interactions with endothelial cells, via binding to its receptor TNFRSF18 (a.k.a. AITR and GITR). | ||||||||||
| 配体家族 | Tumor necrosis factor superfamily ligands | ||||||||||
| 基因/前体 |
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| 单字母多肽序列 | MTLHPSPITCEFLFSTALISPKMCLSHLENMPLSHSRTQGAQRSSWKLWLFCSIVMLLFLCSFSWLIFIFLQLETAKEPCMAKFGPLPSKWQMASSEPPCVNKVSDWKLEILQNGLYLIYGQVAPNANYNDVAPFEVRLYKNKDMIQTLTNKSKIQNVGGTYELHVGDTIDLIFNSEHQVLKNNTYWGIILLANPQFIS | ||||||||||
| 三字母多肽序列 | |||||||||||
| 翻译后修饰 | Predicted N-linked glycosylation of asparagine residues at positions 151 and 183; disulphide bond formation between cysteine residues at positions 80 and 100 | ||||||||||
| 化学修饰 |
产品问答
产品问答
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