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TL6
| 别名 | glucocorticoid- induced TNF-related ligand, activation-inducible TNF-related ligand |
|---|---|
| Compound Class | Peptide |
| 变动原因 | TL6 (official name, tumor necrosis factor ligand superfamily member 18) is a cytokine belonging to the tumor necrosis factor (TNF) ligand family. It is thought to be involved in T cell interactions with endothelial cells, via binding to its receptor TNFRSF18 (a.k.a. AITR and GITR). |
| Species |
Human |
| Related Product | TL6 |
Summary
| 基因/前体 |
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| 是否批准为药物？ | |||||||||||
| IUPAC Name | 4-amino-N-(4,6-dimethylpyrimidin-2-yl)benzenesulfonamide | ||||||||||
| 别名 | glucocorticoid- induced TNF-related ligand, activation-inducible TNF-related ligand |
数据库链接
| UniProtKB | Q9UNG2 |
|---|---|
| Wikipedia | TNFSF18 |
| RCSB PDB Structure | 2Q1M |
| Ensembl Gene | ENSG00000120337 |
| CATH/Gene3D | 2.60.120.40 |
生物活性
| 生物活性评价 |
The sulfonamide class of antibacterial compounds are primarily bacteriostatic agents and have a broad spectrum of activity against both Gram-positive and Gram-negative species of bacteria (reviewed in |
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| 关联靶标 | glucocorticoid-induced TNF receptor |
临床资料
| 作用机制与药效学效应 |
Sulfonamides are structural analogues of 4-aminobenzoic acid (pABA) an intermediate in the de novo synthesis of folate by some prokaryotes, lower eukaryotes and plants |
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结构
| Peptide Sequence | MTLHPSPITCEFLFSTALISPKMCLSHLENMPLSHSRTQGAQRSSWKLWLFCSIVMLLFLCSFSWLIFIFLQLETAKEPCMAKFGPLPSKWQMASSEPPCVNKVSDWKLEILQNGLYLIYGQVAPNANYNDVAPFEVRLYKNKDMIQTLTNKSKIQNVGGTYELHVGDTIDLIFNSEHQVLKNNTYWGIILLANPQFIS |
|---|---|
| Post Translation Modifications | Predicted N-linked glycosylation of asparagine residues at positions 151 and 183; disulphide bond formation between cysteine residues at positions 80 and 100 |
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