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IL-37

有货

库存信息

关闭

库存信息

关闭

货号 (SKU)	包装规格	是否现货	价格	数量
rp174311-500μg	500μg	期货
rp174311-1mg	1mg	期货

查看相关系列

Interleukin-18 receptor Agonist single Ig and TIR domain containing Agonist

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基本描述

产品名称	IL-37

产品规格参数

CAS编号和信息	rp174311

数据库链接

UniProtKB	Q9NZH6
Entrez Gene	27178
Ensembl Gene	ENSG00000125571

靶标

Target ID	1908
名称	Interleukin-18 receptor
缩写名	SHP2
家族	Immunoglobulin-like family of IL-1 receptors
别名	GPR167

Target ID

2969

名称

single Ig and TIR domain containing

缩写名

SHP2

家族

Immunoglobulin-like family of IL-1 receptors

别名

GPR167

基因和蛋白信息

Species	Transmembrane Domains	Amino Acids	Chromosomal Location	Gene Symbol	Gene Name
Human	1	410	11p15.5	SIGIRR	single Ig and TIR domain containing
Mouse	1	409	7 F5	Sigirr	single immunoglobulin and toll-interleukin 1 receptor (TIR) domain
Rat	1	409	1q41	Sigirr	single Ig and TIR domain containing

RefSeq Protein

NP_001128526 (Hs) , NP_075546 (Mm) , NP_001020058 (Rn)

RefSeq Nucleotide

NM_001135054 (Hs) , NM_023059 (Mm) , NM_001024887 (Rn)

UniProtKB

Q6IA17 (Hs) , Q9JLZ8 (Mm) , Q4V892 (Rn)

Ensembl Gene

ENSG00000185187 (Hs) , ENSMUSG00000025494 (Mm) , ENSRNOG00000015593 (Rn)

OMIM

605478 (Hs)

Entrez Gene

59307 (Hs) , 24058 (Mm) , 309106 (Rn)

Protein GI

76363407 (Rn) , 76363406 (Mm) , 311033538 (Hs)

关联配体

Ligand ID

6149

名称

IL-37

别名

interleukin-1ζ

类别

Peptide

学名

4-amino-N-(4,6-dimethylpyrimidin-2-yl)benzenesulfonamide

生物活性评价

The sulfonamide class of antibacterial compounds are primarily bacteriostatic agents and have a broad spectrum of activity against both Gram-positive and Gram-negative species of bacteria (reviewed in ).

评价

IL-37 is an anti-inflammatory cytokine of the innate immune system.

配体家族

Interleukins

基因/前体

Gene symbol	Gene name	Precursor protein name	Species	别名
IL37	interleukin 37	prepro-interleukin-37	Human	IL1F7, interleukin 1 family, member 7 (zeta), FIL1, FIL1(ZETA), FIL1Z, IL-1F7, IL-1H4, IL-1RP1, interleukin 1, zeta, interleukin-1 homolog 4, interleukin-1-related protein

单字母多肽序列

VHTSPKVKNLNPKKFSIHDQDHKVLVLDSGNLIAVPDKNYIRPEIFFALASSLSSASAEKGSPILLGVSKGEFCLYCDKDKGQSHPSLQLKKEKLMKLAAQKESARRPFIFYRAQVGSWNMLESAAHPGWFICTSCNCNEPVGVTDKFENRKHIEFSFQPVCKAEMSPSEVSD

三字母多肽序列

翻译后修饰

化学修饰

参考文献

1. Nold MF, Nold-Petry CA, Zepp JA, Palmer BE, Bufler P, Dinarello CA. (2010) IL-37 is a fundamental inhibitor of innate immunity.. Nat Immunol, 11 (11): (1014-22). [PMID:20935647]
2. Cavalli G, Koenders M, Kalabokis V, Kim J, Tan AC, Garlanda C, Mantovani A, Dagna L, Joosten LA, Dinarello CA. (2016) Treating experimental arthritis with the innate immune inhibitor interleukin-37 reduces joint and systemic inflammation.. Rheumatology (Oxford), 55 (12): (2220-2229). [PMID:27567100]