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CCL5

功能和特点
有货

库存信息

关闭

库存信息

关闭
货号 (SKU) 包装规格 是否现货 价格 数量
rp173681-500μg
 500μg 期货 Stock Image
rp173681-1mg
 1mg 期货 Stock Image
大包装询价 添加到收藏夹 比较
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CCR1 Agonist CCR3 Agonist CCR5 Agonist CXCR3 Agonist GPR75 Agonist
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基本描述

产品名称 CCL5

产品规格参数

CAS编号和信息 rp173681

靶标

Target ID 58
名称 CCR1
缩写名 SHP2
家族 Chemokine receptors
别名 m1
基因和蛋白信息
Species Transmembrane Domains Amino Acids Chromosomal Location Gene Symbol Gene Name
Rat 7 355 8q32 Ccr1 C-C motif chemokine receptor 1
Human 7 355 3p21.31 CCR1 C-C motif chemokine receptor 1
Mouse 7 355 9 75.05 cM Ccr1 chemokine (C-C motif) receptor 1
RefSeq Protein NP_065417 (Rn) , NP_001286 (Hs) , NP_034042 (Mm)
UniProtKB Q9JLY8 (Rn) , P32246 (Hs) , P51675 (Mm)
OMIM 601159 (Hs)
RefSeq Nucleotide NM_001295 (Hs) , NM_020542 (Rn) , NM_009912 (Mm)
Entrez Gene 1230 (Hs) , 57301 (Rn) , 12768 (Mm)
Ensembl Gene ENSG00000163823 (Hs) , ENSMUSG00000025804 (Mm) , ENSRNOG00000006715 (Rn)
Protein GI 157012007 (Mm) , 4502631 (Hs) , 10120494 (Rn)
GPCRdb ccr1_human (Hs) , ccr1_mouse (Mm) , q9jly8_rat (Rn)
UniProtKB ID/Entry name CCR1_HUMAN (Hs) , CCR1_MOUSE (Mm) , Q9JLY8_RAT (Rn)
ChEMBL Target CHEMBL5499 (Rn) , CHEMBL2413 (Hs) , CHEMBL3872 (Mm)
Target ID 60
名称 CCR3
缩写名 SHP2
家族 Chemokine receptors
别名 m1
基因和蛋白信息
Species Transmembrane Domains Amino Acids Chromosomal Location Gene Symbol Gene Name
Rat 7 359 8q32 Ccr3 C-C motif chemokine receptor 3
Human 7 355 3p21.31 CCR3 C-C motif chemokine receptor 3
Mouse 7 359 9 75.05 cM Ccr3 chemokine (C-C motif) receptor 3
RefSeq Protein NP_446410 (Rn) , NP_001828 (Hs) , NP_034044 (Mm)
UniProtKB O54814 (Rn) , P51677 (Hs) , P51678 (Mm)
OMIM 601268 (Hs)
RefSeq Nucleotide NM_001837 (Hs) , NM_053958 (Rn) , NM_009914 (Mm)
Entrez Gene 1232 (Hs) , 117027 (Rn) , 12771 (Mm)
Ensembl Gene ENSG00000183625 (Hs) , ENSMUSG00000035448 (Mm) , ENSRNOG00000006736 (Rn)
Protein GI 16758844 (Rn) , 157012009 (Mm) , 257743048 (Hs)
GPCRdb ccr3_human (Hs) , ccr3_mouse (Mm) , ccr3_rat (Rn)
UniProtKB ID/Entry name CCR3_HUMAN (Hs) , CCR3_MOUSE (Mm) , CCR3_RAT (Rn)
ChEMBL Target CHEMBL3406 (Mm) , CHEMBL3473 (Hs) , CHEMBL3928 (Rn)
Target ID 62
名称 CCR5
缩写名 SHP2
家族 Chemokine receptors
别名 m1
基因和蛋白信息
Species Transmembrane Domains Amino Acids Chromosomal Location Gene Symbol Gene Name
Rat 7 354 8q32 Ccr5 C-C motif chemokine receptor 5
Human 7 352 3p21.31 CCR5 C-C motif chemokine receptor 5
Mouse 7 354 9 75.05 cM Ccr5 chemokine (C-C motif) receptor 5
RefSeq Protein NP_446412 (Rn) , NP_000570 (Hs) , NP_034047 (Mm)
UniProtKB O08556 (Rn) , P51681 (Hs) , P51682 (Mm)
OMIM 601373 (Hs)
RefSeq Nucleotide NM_000579 (Hs) , NM_053960 (Rn) , NM_009917 (Mm)
Entrez Gene 1234 (Hs) , 117029 (Rn) , 12774 (Mm)
Ensembl Gene ENSG00000160791 (Hs) , ENSMUSG00000079227 (Mm) , ENSRNOG00000049115 (Rn)
Protein GI 31542356 (Mm) , 154091328 (Hs) , 51592090 (Rn)
GPCRdb ccr5_human (Hs) , ccr5_mouse (Mm) , ccr5_rat (Rn)
UniProtKB ID/Entry name CCR5_HUMAN (Hs) , CCR5_MOUSE (Mm) , CCR5_RAT (Rn)
DrugBank Target P51681 (Hs)
ChEMBL Target CHEMBL3676 (Mm) , CHEMBL1795146 (Rn) , CHEMBL274 (Hs)
Target ID 70
名称 CXCR3
缩写名 SHP2
家族 Chemokine receptors
别名 m1
基因和蛋白信息
Species Transmembrane Domains Amino Acids Chromosomal Location Gene Symbol Gene Name
Rat 7 367 Xq22 Cxcr3 C-X-C motif chemokine receptor 3
Human 7 368 Xq13.1 CXCR3 C-X-C motif chemokine receptor 3
Mouse 7 367 X 44.58 cM Cxcr3 chemokine (C-X-C motif) receptor 3
RefSeq Protein NP_445867 (Rn) , NP_001495 (Hs) , NP_034040 (Mm)
UniProtKB Q9JII9 (Rn) , P49682 (Hs) , O88410 (Mm)
OMIM 600894 (Hs)
RefSeq Nucleotide NM_001504 (Hs) , NM_053415 (Rn) , NM_009910 (Mm)
Entrez Gene 2833 (Hs) , 84475 (Rn) , 12766 (Mm)
Ensembl Gene ENSG00000186810 (Hs) , ENSMUSG00000050232 (Mm) , ENSRNOG00000003305 (Rn)
Protein GI 218563730 (Hs) , 16758152 (Rn) , 6753458 (Mm)
GPCRdb cxcr3_human (Hs) , cxcr3_mouse (Mm) , cxcr3_rat (Rn)
UniProtKB ID/Entry name CXCR3_HUMAN (Hs) , CXCR3_MOUSE (Mm) , CXCR3_RAT (Rn)
ChEMBL Target CHEMBL1075172 (Rn) , CHEMBL5200 (Mm) , CHEMBL4441 (Hs)
Target ID 115
名称 GPR75
缩写名 SHP2
家族 Class A Orphans
别名 m3
基因和蛋白信息
Species Transmembrane Domains Amino Acids Chromosomal Location Gene Symbol Gene Name
Rat 7 540 14q22 Gpr75 G protein-coupled receptor 75
Human 7 540 2p16.2 GPR75 G protein-coupled receptor 75
Mouse 7 540 11 A4 Gpr75 G protein-coupled receptor 75
RefSeq Protein NP_001102566 (Rn) , NP_006785 (Hs) , NP_780699 (Mm)
UniProtKB O95800 (Hs) , Q6X632 (Mm) , D3Z826 (Rn)
OMIM 606704 (Hs)
RefSeq Nucleotide NM_006794 (Hs) , NM_001109096 (Rn) , NM_175490 (Mm)
Entrez Gene 10936 (Hs) , 498434 (Rn) , 237716 (Mm)
Ensembl Gene ENSG00000119737 (Hs) , ENSMUSG00000043999 (Mm) , ENSRNOG00000022176 (Rn)
Protein GI 47059091 (Mm) , 157819133 (Rn) , 5803025 (Hs)
dbSNP rs75729621 (Hs) , rs1127767 (Hs) , rs34000641 (Hs) , rs35349235 (Hs) , rs138373994 (Hs)
UniProtKB Variant VAR_033471 (Hs) , VAR_033472 (Hs)
GPCRdb gpr75_human (Hs) , gpr75_mouse (Mm) , d3z826_rat (Rn)
UniProtKB ID/Entry name GPR75_HUMAN (Hs) , GPR75_MOUSE (Mm) , D3Z826_RAT (Rn)
ChEMBL Target CHEMBL4523861 (Hs)

关联配体

Ligand ID 758
名称 CCL5
别名 regulated upon activation normal T cell expressed and secreted (RANTES)
类别 Peptide
学名 4-amino-N-(4,6-dimethylpyrimidin-2-yl)benzenesulfonamide
生物活性评价 The sulfonamide class of antibacterial compounds are primarily bacteriostatic agents and have a broad spectrum of activity against both Gram-positive and Gram-negative species of bacteria (reviewed in ).
评价 CCL5 (also known as RANTES- an acronym for regulated on activation, normal T cell expressed and secreted) is a CC family chemokine, that has HIV suppressive activity, as do the related CD8+ T cell chemokines and .
配体家族 Chemokines
基因/前体
Gene symbol Gene name Precursor protein name Species 别名
CCL5 C-C motif chemokine ligand 5 chemokine (C-C motif) ligand 5 Human D17S136E, SCYA5, RANTES, SISd, TCP228, MGC17164, small inducible cytokine A5 (RANTES), T-cell specific protein p288, T-cell specific RANTES protein, SIS-delta, regulated upon activation, normally T-expressed, and presumably secreted, beta-chemokine RANTES, small inducible cytokine subfamily A (Cys-Cys), member 5, chemokine (C-C motif) ligand 5
单字母多肽序列 SPYSSDTTPCCFAYIARPLPRAHIKEYFYTSGKCSNPAVVFVTRKNRQVCANPEKKWVREYINSLEMS
三字母多肽序列 Ser-Pro-Tyr-Ser-Ser-Asp-Thr-Thr-Pro-Cys-Cys-Phe-Ala-Tyr-Ile-Ala-Arg-Pro-Leu-Pro-Arg-Ala-His-Ile-Lys-Glu-Tyr-Phe-Tyr-Thr-Ser-Gly-Lys-Cys-Ser-Asn-Pro-Ala-Val-Val-Phe-Val-Thr-Arg-Lys-Asn-Arg-Gln-Val-Cys-Ala-Asn-Pro-Glu-Lys-Lys-Trp-Val-Arg-Glu-Tyr-Ile-Asn-Ser-Leu-Glu-Met-Ser
翻译后修饰 2 N-terminally truncated forms are found (RANTES(3-68) and RANTES(4-68) ). Also, these forms together with RANTES include post-translational glycosylation of amino acids at position 27 and 28.
化学修饰

参考文献

1. Song A, Nikolcheva T, Krensky AM.  (2000)  Transcriptional regulation of RANTES expression in T lymphocytes..  Immunol Rev,  177  (13):  (236-45).  [PMID:11138780]
2. Maghazachi AA, Al-Aoukaty A, Schall TJ.  (1996)  CC chemokines induce the generation of killer cells from CD56+ cells..  Eur J Immunol,  26  (2):  (315-9).  [PMID:8617297]

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