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BAFF

有货

库存信息

关闭

库存信息

关闭

货号 (SKU)	包装规格	是否现货	价格	数量
rp173517-500μg	500μg	期货
rp173517-1mg	1mg	期货

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B cell maturation antigen BAFF receptor TACI

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基本描述

产品名称	BAFF

产品规格参数

CAS编号和信息	rp173517

数据库链接

UniProtKB	Q9Y275
Wikipedia	TNFSF13B
RCSB PDB Structure	1jh5
Ensembl Gene	ENSG00000102524
Protein GI	49456593
DrugBank Target	Q9Y275
CATH/Gene3D	2.60.120.40

靶标

Target ID

1885

名称

TACI

缩写名

SHP2

家族

Tumour necrosis factor (TNF) receptor family

基因和蛋白信息

Species	Transmembrane Domains	Amino Acids	Chromosomal Location	Gene Symbol	Gene Name
Human	1	293	17p11.2	TNFRSF13B	TNF receptor superfamily member 13B
Mouse	1	249	11 B2	Tnfrsf13b	tumor necrosis factor receptor superfamily, member 13b
Rat	2	147	18p11	Tnfrsf13b	TNF receptor superfamily member 13B

Ensembl Gene

ENSMUSG00000010142 (Mm) , ENSRNOG00000002304 (Rn) , ENSG00000240505 (Hs)

Entrez Gene

57916 (Mm) , 691719 (Rn) , 23495 (Hs)

OMIM

604907 (Hs)

Protein GI

10946668 (Mm) , 293351553 (Rn) , 6912694 (Hs)

UniProtKB

O14836 (Hs) , Q9ET35 (Mm)

Target ID

1886

名称

BAFF receptor

缩写名

BAFF-R

家族

Tumour necrosis factor (TNF) receptor family

基因和蛋白信息

Species	Transmembrane Domains	Amino Acids	Chromosomal Location	Gene Symbol	Gene Name
Human	1	184	22q13.2	TNFRSF13C	TNF receptor superfamily member 13C
Mouse	1	175	15 E1	Tnfrsf13c	tumor necrosis factor receptor superfamily, member 13c
Rat	2	147	18p11	Tnfrsf13c	TNF receptor superfamily member 13C

Ensembl Gene

ENSG00000159958 (Hs) , ENSMUSG00000068105 (Mm) , ENSRNOG00000007664 (Rn)

Entrez Gene

72049 (Mm) , 500910 (Rn) , 115650 (Hs)

OMIM

606269 (Hs)

Protein GI

16445027 (Hs) , 109482630 (Rn) , 16306481 (Mm)

UniProtKB

Q96RJ3 (Hs) , Q9D8D0 (Mm)

ChEMBL Target

CHEMBL4630882 (Hs)

Target ID

1889

名称

B cell maturation antigen

缩写名

BCMA

家族

Tumour necrosis factor (TNF) receptor family

基因和蛋白信息

Species	Transmembrane Domains	Amino Acids	Chromosomal Location	Gene Symbol	Gene Name
Human	1	184	16p13.13	TNFRSF17	TNF receptor superfamily member 17
Mouse	1	185	16 A1	Tnfrsf17	tumor necrosis factor receptor superfamily, member 17
Rat	2	147	18p11	Tnfrsf17	TNF receptor superfamily member 17

Ensembl Gene

ENSG00000048462 (Hs) , ENSMUSG00000022496 (Mm) , ENSRNOG00000021987 (Rn)

Entrez Gene

21935 (Mm) , 287034 (Rn) , 608 (Hs)

OMIM

109545 (Hs)

Protein GI

157786580 (Rn) , 6755823 (Mm) , 23238192 (Hs)

UniProtKB

Q02223 (Hs) , O88472 (Mm)

ChEMBL Target

CHEMBL4523587 (Hs) , CHEMBL1250345 (Mm)

关联配体

Ligand ID

5069

名称

BAFF

别名

B cell-activating factor

类别

Peptide

学名

4-amino-N-(4,6-dimethylpyrimidin-2-yl)benzenesulfonamide

生物活性评价

The sulfonamide class of antibacterial compounds are primarily bacteriostatic agents and have a broad spectrum of activity against both Gram-positive and Gram-negative species of bacteria (reviewed in ).

评价

The TNFSF13B precursor is also cleaved into a soluble form of the ligand.

配体家族

CD molecules (ligands)

基因/前体

Gene symbol	Gene name	Precursor protein name	Species	别名
TNFSF13B	TNF superfamily member 13b	prepro-tumor necrosis factor ligand superfamily member 13b	Human	TNFSF20, BAFF, THANK, BLYS, TALL-1, TALL1, CD257, tumor necrosis factor (ligand) superfamily, member 13b, tumor necrosis factor superfamily member 13b

单字母多肽序列

MDDSTEREQSRLTSCLKKREEMKLKECVSILPRKESPSVRSSKDGKLLAATLLLALLSCCLTVVSFYQVAALQGDLASLRAELQGHHAEKLPAGAGAPKAGLEEAPAVTAGLKIFEPPAPGEGNSSQNSRNKRAVQGPEETVTQDCLQLIADSETPTIQKGSYTFVPWLLSFKRGSALEEKENKILVKETGYFFIYGQVLYTDKTYAMGHLIQRKKVHVFGDELSLVTLFRCIQNMPETLPNNSCYSAGIAKLEEGDELQLAIPRENAQISLDGDVTFFGALKLL

三字母多肽序列

翻译后修饰

N-linked glycosylation of asparagine residues at positions 124 and 242 (high mannose at 242); disulphide bond formation between cysteine residues at positions 232 and 245

化学修饰

参考文献

1. Samy E, Wax S, Huard B, Hess H, Schneider P. (2017) Targeting BAFF and APRIL in systemic lupus erythematosus and other antibody-associated diseases.. Int Rev Immunol, 36 (1): (3-19). [PMID:28215100]
2. Lazaro E, Scherlinger M, Truchetet ME, Chiche L, Schaeverbeke T, Blanco P, Richez C. (2017) Biotherapies in systemic lupus erythematosus: New targets.. Joint Bone Spine, 84 (3): (267-274). [PMID:27663753]