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BAFF

别名 B cell-activating factor, dendritic cell-derived TNF-like molecule, CD257 antigen
Compound Class Peptide
变动原因 The TNFSF13B precursor is also cleaved into a soluble form of the ligand.
Species Human
Related Product BAFF

Summary

基因/前体
Gene symbol Gene name Precursor protein name Species 别名
TNFSF13B TNF superfamily member 13b prepro-tumor necrosis factor ligand superfamily member 13b Human TNFSF20, BAFF, THANK, BLYS, TALL-1, TALL1, CD257, tumor necrosis factor (ligand) superfamily, member 13b, tumor necrosis factor superfamily member 13b
是否批准为药物？
IUPAC Name 4-amino-N-(4,6-dimethylpyrimidin-2-yl)benzenesulfonamide
别名 B cell-activating factor, dendritic cell-derived TNF-like molecule, CD257 antigen

生物活性

生物活性评价 The sulfonamide class of antibacterial compounds are primarily bacteriostatic agents and have a broad spectrum of activity against both Gram-positive and Gram-negative species of bacteria (reviewed in ).
关联靶标 TACI , BAFF receptor , B cell maturation antigen

临床资料

作用机制与药效学效应 Sulfonamides are structural analogues of 4-aminobenzoic acid (pABA) an intermediate in the de novo synthesis of folate by some prokaryotes, lower eukaryotes and plants . The antibacterial MMOA is competitive inhibition of bacterial dihydropteroate synthase (DHPS) resulting in a block of folate biosynthesis .

参考文献

1. Lazaro E, Scherlinger M, Truchetet ME, Chiche L, Schaeverbeke T, Blanco P, Richez C.  (2017)  Biotherapies in systemic lupus erythematosus: New targets..  Joint Bone Spine,  84  (3):  (267-274).  [PMID:27663753]
2. Samy E, Wax S, Huard B, Hess H, Schneider P.  (2017)  Targeting BAFF and APRIL in systemic lupus erythematosus and other antibody-associated diseases..  Int Rev Immunol,  36  (1):  (3-19).  [PMID:28215100]

结构

Peptide Sequence MDDSTEREQSRLTSCLKKREEMKLKECVSILPRKESPSVRSSKDGKLLAATLLLALLSCCLTVVSFYQVAALQGDLASLRAELQGHHAEKLPAGAGAPKAGLEEAPAVTAGLKIFEPPAPGEGNSSQNSRNKRAVQGPEETVTQDCLQLIADSETPTIQKGSYTFVPWLLSFKRGSALEEKENKILVKETGYFFIYGQVLYTDKTYAMGHLIQRKKVHVFGDELSLVTLFRCIQNMPETLPNNSCYSAGIAKLEEGDELQLAIPRENAQISLDGDVTFFGALKLL
Post Translation Modifications N-linked glycosylation of asparagine residues at positions 124 and 242 (high mannose at 242); disulphide bond formation between cysteine residues at positions 232 and 245
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