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基本描述
| 规格或纯度 | 10mM in DMSO |
|---|---|
| 英文名称 | PfDHODH-IN-2 |
| 生化机理 | PfDHODH-IN-2, a dihydrothiophenone derivative (Compound 11), is a potent Plasmodium falciparum dihydroorotate dehydrogenase ( Pf DHODH) inhibitor with an IC 50 of 1.11 μM. PfDHODH-IN-2 acts as an antimalarial agent and can be used for the research of mala |
| 储存温度 | -80℃储存 |
| 运输条件 | 超低温冰袋运输 |
| 产品介绍 |
PfDHODH-IN-2, a dihydrothiophenone derivative (Compound 11), is a potent Plasmodium falciparum dihydroorotate dehydrogenase ( Pf DHODH) inhibitor with an IC 50 of 1.11 μM. PfDHODH-IN-2 acts as an antimalarial agent and can be used for the research of malaria In Vitro Malaria is a global parasitic infectious disease caused by Plasmodium parasites, among which Plasmodium falciparum is the most dangerous one with the highest rates of complications and mortality. PfDHODH-IN-2 shows an overall selectivity for PfDHODH (IC 50 =1.113 μM) over hDHODH (IC 50 >50 μM). PfDHODH-IN-2 demonstrats in vitro potency against the 3D7 and Dd2 strains of P. falciparum with IC 50 values of both >20 μM, respectively in whole cell assays. MCE has not independently confirmed the accuracy of these methods. They are for reference only. IC50& Target:IC50: 1.113 μM (PfDHODH) IC50: >50 μM ( hDHODH) |
名称和标识符
| Canonical SMILES | CCOC(=O)C1=C(CSC1=NC2=CC=C(C=C2)Cl)O |
|---|---|
| 分子量 | 297.76 |
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产品问答
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