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多肽YY(人)

规格或纯度: ≥97% (HPLC)
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P118902-1mg 1mg 现货 Stock Image
P118902-5mg 5mg 现货 Stock Image
P118902-10mg 10mg 现货 Stock Image
P118902-25mg 25mg 现货 Stock Image
P118902-50mg 50mg 现货 Stock Image
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Y1 receptor Agonist Y2 receptor Agonist Y4 receptor Agonist
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基本描述

规格或纯度 ≥97% (HPLC)
英文名称 Peptide YY human
别名 PYY Tyr-Pro-Ile-Lys-Pro-Glu-Ala-Pro-Gly-Glu-Asp-Ala-Ser-Pro-Glu-Glu-Leu-Asn-Arg-Tyr-Tyr-Ala-Ser-Leu-Arg-His-Tyr-Leu-Asn-Leu-Val-Thr-Arg-Gln-Arg-Tyr-NH2；PYY
英文别名 PYY Tyr-Pro-Ile-Lys-Pro-Glu-Ala-Pro-Gly-Glu-Asp-Ala-Ser-Pro-Glu-Glu-Leu-Asn-Arg-Tyr-Tyr-Ala-Ser-Leu-Arg-His-Tyr-Leu-Asn-Leu-Val-Thr-Arg-Gln-Arg-Tyr-NH2
生化机理 Gut hormone that inhibits both secretin and cholecystokinin-stimulated pancreatic secretion. Endogenous nonselective agonist at NPY receptors. Human peptide YY (PYY) has a role in food ingestion, gut motility and insulin secretion. The protein suppresses appetite. It has been associated with obesity and type 2 diabetes. PYY also has a role in energy homeostasis.
储存温度 避光,-20°C储存
运输条件 超低温冰袋运输
产品介绍

产品介绍：

eptideYY(PYY)是一种肠道激素，可调节食欲和抑制胰腺分泌。PeptideYY(PYY)可以通过神经肽Y受体(NeuropeptideYreceptors)介导其作用。

Lyophilized from 0.1% TFA in H2O


application：

Peptide YY human has been used as a supplement in Roswell Park Memorial Institute medium (RPMI medium) to culture pancreatic duct-derived cells.

名称和标识符

IUPAC Name (4S)-5-[[(2S)-1-[[(2S)-1-[[(2S)-1-[(2S)-2-[[(2S)-1-[[(2S)-1-[[(2S)-1-[[(2S)-4-amino-1-[[(2S)-1-[[(2S)-1-[[(2S)-1-[[(2S)-1-[[(2S)-1-[[(2S)-1-[[(2S)-1-[[(2S)-1-[[(2S)-1-[[(2S)-1-[[(2S)-4-amino-1-[[(2S)-1-[[(2S)-1-[[(2S,3R)-1-[[(2S)-1-[[(2S)-5-amino-1-[[(2S)-1-[[(2S)-1-amino-3-(4-hydroxyphenyl)-1-oxopropan-2-yl]amino]-5-carbamimidamido-1-oxopentan-2-yl]amino]-1,5-dioxopentan-2-yl]amino]-5-carbamimidamido-1-oxopentan-2-yl]amino]-3-hydroxy-1-oxobutan-2-yl]amino]-3-methyl-1-oxobutan-2-yl]amino]-4-methyl-1-oxopentan-2-yl]amino]-1,4-dioxobutan-2-yl]amino]-4-methyl-1-oxopentan-2-yl]amino]-3-(4-hydroxyphenyl)-1-oxopropan-2-yl]amino]-3-(1H-imidazol-4-yl)-1-oxopropan-2-yl]amino]-5-carbamimidamido-1-oxopentan-2-yl]amino]-4-methyl-1-oxopentan-2-yl]amino]-3-hydroxy-1-oxopropan-2-yl]amino]-1-oxopropan-2-yl]amino]-3-(4-hydroxyphenyl)-1-oxopropan-2-yl]amino]-3-(4-hydroxyphenyl)-1-oxopropan-2-yl]amino]-5-carbamimidamido-1-oxopentan-2-yl]amino]-1,4-dioxobutan-2-yl]amino]-4-methyl-1-oxopentan-2-yl]amino]-4-carboxy-1-oxobutan-2-yl]amino]-4-carboxy-1-oxobutan-2-yl]carbamoyl]pyrrolidin-1-yl]-3-hydroxy-1-oxopropan-2-yl]amino]-1-oxopropan-2-yl]amino]-3-carboxy-1-oxopropan-2-yl]amino]-4-[[2-[[(2S)-1-[(2S)-2-[[(2S)-2-[[(2S)-1-[(2S)-6-amino-2-[[(2S,3S)-2-[[(2S)-1-[(2S)-2-amino-3-(4-hydroxyphenyl)propanoyl]pyrrolidine-2-carbonyl]amino]-3-methylpentanoyl]amino]hexanoyl]pyrrolidine-2-carbonyl]amino]-4-carboxybutanoyl]amino]propanoyl]pyrrolidine-2-carbonyl]amino]acetyl]amino]-5-oxopentanoic acid
INCHI InChI=1S/C194H295N55O57/c1-17-99(12)154(244-183(299)143-36-25-73-247(143)188(304)115(196)80-104-37-47-110(253)48-38-104)185(301)228-125(28-18-19-67-195)189(305)248-74-26-34-141(248)181(297)225-122(59-64-149(264)265)159(275)218-102(15)187(303)246-72-24-33-140(246)180(296)214-90-147(261)219-120(58-63-148(262)263)164(280)240-137(88-152(270)271)169(285)217-101(14)158(274)242-139(92-251)190(306)249-75-27-35-142(249)182(298)226-124(61-66-151(268)269)166(282)224-123(60-65-150(266)267)167(283)230-128(77-95(4)5)171(287)238-135(86-145(198)259)176(292)222-117(30-21-69-211-192(203)204)162(278)234-132(83-107-43-53-113(256)54-44-107)174(290)235-131(82-106-41-51-112(255)52-42-106)168(284)216-100(13)157(273)241-138(91-250)179(295)233-127(76-94(2)3)170(286)221-118(31-22-70-212-193(205)206)163(279)237-134(85-109-89-209-93-215-109)175(291)236-133(84-108-45-55-114(257)56-46-108)173(289)231-129(78-96(6)7)172(288)239-136(87-146(199)260)177(293)232-130(79-97(8)9)178(294)243-153(98(10)11)184(300)245-155(103(16)252)186(302)227-119(32-23-71-213-194(207)208)160(276)223-121(57-62-144(197)258)165(281)220-116(29-20-68-210-191(201)202)161(277)229-126(156(200)272)81-105-39-49-111(254)50-40-105/h37-56,89,93-103,115-143,153-155,250-257H,17-36,57-88,90-92,195-196H2,1-16H3,(H2,197,258)(H2,198,259)(H2,199,260)(H2,200,272)(H,209,215)(H,214,296)(H,216,284)(H,217,285)(H,218,275)(H,219,261)(H,220,281)(H,221,286)(H,222,292)(H,223,276)(H,224,282)(H,225,297)(H,226,298)(H,227,302)(H,228,301)(H,229,277)(H,230,283)(H,231,289)(H,232,293)(H,233,295)(H,234,278)(H,235,290)(H,236,291)(H,237,279)(H,238,287)(H,239,288)(H,240,280)(H,241,273)(H,242,274)(H,243,294)(H,244,299)(H,245,300)(H,262,263)(H,264,265)(H,266,267)(H,268,269)(H,270,271)(H4,201,202,210)(H4,203,204,211)(H4,205,206,212)(H4,207,208,213)/t99-,100-,101-,102-,103+,115-,116-,117-,118-,119-,120-,121-,122-,123-,124-,125-,126-,127-,128-,129-,130-,131-,132-,133-,134-,135-,136-,137-,138-,139-,140-,141-,142-,143-,153-,154-,155-/m0/s1
InChi Key YNXLOPYTAAFMTN-SBUIBGKBSA-N
Canonical SMILES CCC(C)C(C(=O)NC(CCCCN)C(=O)N1CCCC1C(=O)NC(CCC(=O)O)C(=O)NC(C)C(=O)N2CCCC2C(=O)NCC(=O)NC(CCC(=O)O)C(=O)NC(CC(=O)O)C(=O)NC(C)C(=O)NC(CO)C(=O)N3CCCC3C(=O)NC(CCC(=O)O)C(=O)NC(CCC(=O)O)C(=O)NC(CC(C)C)C(=O)NC(CC(=O)N)C(=O)NC(CCCNC(=N)N)C(=O)NC(CC4=CC=C(C=C4)O)C(=O)NC(CC5=CC=C(C=C5)O)C(=O)NC(C)C(=O)NC(CO)C(=O)NC(CC(C)C)C(=O)NC(CCCNC(=N)N)C(=O)NC(CC6=CNC=N6)C(=O)NC(CC7=CC=C(C=C7)O)C(=O)NC(CC(C)C)C(=O)NC(CC(=O)N)C(=O)NC(CC(C)C)C(=O)NC(C(C)C)C(=O)NC(C(C)O)C(=O)NC(CCCNC(=N)N)C(=O)NC(CCC(=O)N)C(=O)NC(CCCNC(=N)N)C(=O)NC(CC8=CC=C(C=C8)O)C(=O)N)NC(=O)C9CCCN9C(=O)C(CC1=CC=C(C=C1)O)N
分子式

C194H295N55O57
PubChem CID 126455957
分子量 4309.75

化学和物理性质

敏感性 对光和湿度敏感

靶标

Target ID 305
名称 Y1 receptor
缩写名 SHP2
家族 Neuropeptide Y receptors
别名 M-BAR
基因和蛋白信息
Species Transmembrane Domains Amino Acids Chromosomal Location Gene Symbol Gene Name
Rat 7 382 16p14 Npy1r neuropeptide Y receptor Y1
Human 7 384 4q32.2 NPY1R neuropeptide Y receptor Y1
Mouse 7 382 8 33.15 cM Npy1r neuropeptide Y receptor Y1
RefSeq Protein NP_001106828 (Rn) , NP_000900 (Hs) , NP_035064 (Mm)
UniProtKB P21555 (Rn) , P25929 (Hs) , Q04573 (Mm)
OMIM 162641 (Hs)
RefSeq Nucleotide NM_000909 (Hs) , NM_001113357 (Rn) , NM_010934 (Mm)
Entrez Gene 4886 (Hs) , 29358 (Rn) , 18166 (Mm)
Ensembl Gene ENSG00000164128 (Hs) , ENSMUSG00000036437 (Mm) , ENSRNOG00000014149 (Rn)
Protein GI 4505445 (Hs) , 6754882 (Mm) , 164518921 (Rn)
GPCRdb npy1r_human (Hs) , npy1r_mouse (Mm) , npy1r_rat (Rn)
UniProtKB ID/Entry name NPY1R_HUMAN (Hs) , NPY1R_MOUSE (Mm) , NPY1R_RAT (Rn)
ChEMBL Target CHEMBL4739851 (Mm) , CHEMBL4777 (Hs) , CHEMBL2587 (Rn)
Target ID 306
名称 Y2 receptor
缩写名 SHP2
家族 Neuropeptide Y receptors
别名 M-BAR
基因和蛋白信息
Species Transmembrane Domains Amino Acids Chromosomal Location Gene Symbol Gene Name
Rat 7 381 2q34 Npy2r neuropeptide Y receptor Y2
Human 7 381 4q32.1 NPY2R neuropeptide Y receptor Y2
Mouse 7 381 3 36.49 cM Npy2r neuropeptide Y receptor Y2
RefSeq Protein NP_076458 (Rn) , NP_000901 (Hs) , NP_032757 (Mm)
UniProtKB Q9ERC0 (Rn) , P49146 (Hs) , P97295 (Mm)
OMIM 162642 (Hs)
RefSeq Nucleotide NM_000910 (Hs) , NM_023968 (Rn) , NM_008731 (Mm)
Entrez Gene 4887 (Hs) , 66024 (Rn) , 18167 (Mm)
Ensembl Gene ENSG00000185149 (Hs) , ENSMUSG00000028004 (Mm) , ENSRNOG00000049213 (Rn)
Protein GI 13027422 (Rn) , 4505447 (Hs) , 326633237 (Mm)
GPCRdb npy2r_human (Hs) , npy2r_mouse (Mm) , q9erc0_rat (Rn)
UniProtKB ID/Entry name NPY2R_HUMAN (Hs) , NPY2R_MOUSE (Mm) , Q9ERC0_RAT (Rn)
ChEMBL Target CHEMBL3309 (Rn) , CHEMBL4018 (Hs) , CHEMBL4739850 (Mm)
Target ID 307
名称 Y4 receptor
缩写名 SHP2
家族 Neuropeptide Y receptors
别名 M-BAR
基因和蛋白信息
Species Transmembrane Domains Amino Acids Chromosomal Location Gene Symbol Gene Name
Rat 7 375 16p15 Npy4r neuropeptide Y receptor Y4
Human 7 375 10q11.22 NPY4R neuropeptide Y receptor Y4
Mouse 7 375 14 20.8 cM Npy4r neuropeptide Y receptor Y4
RefSeq Protein NP_113769 (Rn) , NP_005963 (Hs) , NP_032945 (Mm)
UniProtKB Q63447 (Rn) , P50391 (Hs) , Q61041 (Mm)
OMIM 601790 (Hs)
RefSeq Nucleotide NM_005972 (Hs) , NM_031581 (Rn) , NM_008919 (Mm)
Entrez Gene 5540 (Hs) , 29471 (Rn) , 19065 (Mm)
Ensembl Gene ENSG00000204174 (Hs) , ENSMUSG00000048337 (Mm) , ENSRNOG00000061026 (Rn)
Protein GI 13928788 (Rn) , 157364957 (Hs) , 157057097 (Mm)
GPCRdb npy4r_human (Hs) , npy4r_mouse (Mm) , npy4r_rat (Rn)
UniProtKB ID/Entry name NPY4R_HUMAN (Hs) , NPY4R_MOUSE (Mm) , NPY4R_RAT (Rn)
ChEMBL Target CHEMBL4877 (Hs) , CHEMBL4827 (Rn) , CHEMBL4105736 (Mm)

关联配体

Ligand ID 1514
名称 peptide YY
别名 peptide YY
类别 Peptide
学名 4-amino-N-(4,6-dimethylpyrimidin-2-yl)benzenesulfonamide
生物活性评价 The sulfonamide class of antibacterial compounds are primarily bacteriostatic agents and have a broad spectrum of activity against both Gram-positive and Gram-negative species of bacteria (reviewed in ).
评价 Peptide YY is a neuropeptide Y2 receptor agonist. It has been investigated as a potential appetite suppressant .
配体家族 Neuropeptides
基因/前体
Gene symbol Gene name Precursor protein name Species 别名
PYY peptide YY prepro-PYY Human PYY1
单字母多肽序列 YPIKPEAPGEDASPEELNRYYASLRHYLNLVTRQRY
三字母多肽序列 Tyr-Pro-Ile-Lys-Pro-Glu-Ala-Pro-Gly-Glu-Asp-Ala-Ser-Pro-Glu-Glu-Leu-Asn-Arg-Tyr-Tyr-Ala-Ser-Leu-Arg-His-Tyr-Leu-Asn-Leu-Val-Thr-Arg-Gln-Arg-Tyr-NH2
翻译后修饰 The C-terminal tyrosine is amidated.
化学修饰
临床描述 The purpose of this trial is to evaluate the safety and tolerability of single escalating doses of Peptide YY3-36 and to determine effects on food intake and serum hormones when administered by intravenous infusion to otherwise healthy overweight adult subjects.
来源公司 Pfizer

参考文献

1. Chen Z, Eriste E, Jonsson AP, Norberg A, Nepomuceno D, Lovenberg TW, Bergman T, Efendic S, J?rnvall H, Sillard R.  (2001)  Ser(13)-phosphorylated PYY from porcine intestine with a potent biological activity..  FEBS Lett,  492  (1-2):  (119-22).  [PMID:11248248]
2. Steinert RE, Poller B, Castelli MC, Drewe J, Beglinger C.  (2010)  Oral administration of glucagon-like peptide 1 or peptide YY 3-36 affects food intake in healthy male subjects..  Am J Clin Nutr,  92  (4):  (810-7).  [PMID:20720259]
3. Nadkarni PP, Costanzo RM, Sakagami M.  (2011)  Pulmonary delivery of peptide YY for food intake suppression and reduced body weight gain in rats..  Diabetes Obes Metab,  13  (5):  (408-17).  [PMID:21226821]
4. Fazen CH, Valentin D, Fairchild TJ, Doyle RP.  (2011)  Oral delivery of the appetite suppressing peptide hPYY(3-36) through the vitamin B12 uptake pathway..  J Med Chem,  54  (24):  (8707-11).  [PMID:22054008]
5. Kuehl PJ, Boyden T, Dobry DE, Doyle-Eisele M, Friesen DT, McDonald JD, Murri BG, Vodak DT, Lyon DK.  (2016)  Inhaled PYY(3-36) dry-powder formulation for appetite suppression..  Drug Dev Ind Pharm,  42  (1):  (150-156).  [PMID:26006332]
6. Tor?ng S, Veedfald S, Rosenkilde MM, Hartmann B, Holst JJ.  (2015)  The anorexic hormone Peptide YY3-36 is rapidly metabolized to inactive Peptide YY3-34 in?vivo..  Physiol Rep,  3  (7):  (1755-70).  [PMID:26197931]

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