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peptide YY

别名	peptide YY, peptide tyrosine tyrosine
Compound Class	Peptide
变动原因	Peptide YY is a neuropeptide Y2 receptor agonist. It has been investigated as a potential appetite suppressant .
Species	Human
Related Product	多肽YY(人)

Summary

基因/前体

Gene symbol	Gene name	Precursor protein name	Species	别名
PYY	peptide YY	prepro-PYY	Human	PYY1

是否批准为药物？

IUPAC Name

4-amino-N-(4,6-dimethylpyrimidin-2-yl)benzenesulfonamide

别名

peptide YY, peptide tyrosine tyrosine

数据库链接

UniProtKB	P10082
CAS Registry No.	118997-30-1
Wikipedia	Peptide_YY
PEP	peptide yy
Ensembl Gene	ENSG00000131096
GPCRdb Ligand	1514

生物活性

生物活性评价	The sulfonamide class of antibacterial compounds are primarily bacteriostatic agents and have a broad spectrum of activity against both Gram-positive and Gram-negative species of bacteria (reviewed in ).
关联靶标	Y₁ receptor , Y₂ receptor , Y₄ receptor , Y₄ receptor , Y₁ receptor , Y₂ receptor

临床资料

Summary of Clinical Use	The anorexic effect of peptide YY(3-36) in overweight patients has been evaluated in early stage clinical trial (for example see NCT00331175). It is likely that the clinical effect of PYY(3-36) was limited by rapid metabolic conversion to the inactive (3-34) peptide .
作用机制与药效学效应	Sulfonamides are structural analogues of 4-aminobenzoic acid (pABA) an intermediate in the de novo synthesis of folate by some prokaryotes, lower eukaryotes and plants . The antibacterial MMOA is competitive inhibition of bacterial dihydropteroate synthase (DHPS) resulting in a block of folate biosynthesis .

参考文献

1. Kuehl PJ, Boyden T, Dobry DE, Doyle-Eisele M, Friesen DT, McDonald JD, Murri BG, Vodak DT, Lyon DK. (2016) Inhaled PYY(3-36) dry-powder formulation for appetite suppression.. Drug Dev Ind Pharm, 42 (1): (150-156). [PMID:26006332]
2. Fazen CH, Valentin D, Fairchild TJ, Doyle RP. (2011) Oral delivery of the appetite suppressing peptide hPYY(3-36) through the vitamin B12 uptake pathway.. J Med Chem, 54 (24): (8707-11). [PMID:22054008]
3. Nadkarni PP, Costanzo RM, Sakagami M. (2011) Pulmonary delivery of peptide YY for food intake suppression and reduced body weight gain in rats.. Diabetes Obes Metab, 13 (5): (408-17). [PMID:21226821]
4. Steinert RE, Poller B, Castelli MC, Drewe J, Beglinger C. (2010) Oral administration of glucagon-like peptide 1 or peptide YY 3-36 affects food intake in healthy male subjects.. Am J Clin Nutr, 92 (4): (810-7). [PMID:20720259]
5. Tor?ng S, Veedfald S, Rosenkilde MM, Hartmann B, Holst JJ. (2015) The anorexic hormone Peptide YY3-36 is rapidly metabolized to inactive Peptide YY3-34 in?vivo.. Physiol Rep, 3 (7): (1755-70). [PMID:26197931]

结构

Peptide Sequence	YPIKPEAPGEDASPEELNRYYASLRHYLNLVTRQRY
Post Translation Modifications	The C-terminal tyrosine is amidated.

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