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小鼠饥饿素-28

内源性GHS激动剂

规格或纯度: 95%

CAS编号: 258338-12-4
分子式: C₁₄₇H₂₄₅N₄₅O₄₂
分子量: 3314.8
PubChem编号: 44134734

有货

库存信息

关闭

库存信息

关闭

货号 (SKU)	包装规格	是否现货	价格	数量
G111460-1mg	1mg	现货
G111460-5mg	5mg	现货

查看相关系列

ghrelin receptor Agonist

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基本描述

规格或纯度	95%
英文名称	Rat ghrelin-28
别名	生长激素释放肽
英文别名	Ghrelin (rat)
生化机理	ghrelin（GHS）受体的内源性激动剂肽。刺激垂体释放生长激素，并调节进食，生长和能量产生。
储存温度	-20°C储存
运输条件	超低温冰袋运输
备注	如果有可能，您尽量在使用的当天配置溶液，并在当天使用完它。但是，如果您需要预先配制储备溶液，我们建议您将溶液等份保存在-20°C的密封小瓶中。通常，这些产品最多可以使用一周。在使用前和打开样品瓶之前，我们建议您让您的产品在室温下平衡至少1小时。需要更多关于溶解度，用法和处理的建议吗？请访问我们的常见问题（FAQ）页面以获取更多详细信息。
产品介绍	氨基酸序列：Gly-Ser-Ser(n-octanoyl)-Phe-Leu-Ser-Pro-Glu-His-Gln-Lys-Ala-Gln-Gln-Arg-Lys-Glu-Ser-Lys-Lys-Pro-Pro-Ala-Lys-Leu-Gln-Pro- Arg The amino acid sequence：Gly-Ser-Ser(n-octanoyl)-Phe-Leu-Ser-Pro-Glu-His-Gln-Lys-Ala-Gln-Gln-Arg-Lys-Glu-Ser-Lys-Lys-Pro-Pro-Ala-Lys-Leu-Gln-Pro- Arg

名称和标识符

分子式	C₁₄₇H₂₄₅N₄₅O₄₂
PubChem CID	44134734
分子量	3314.8

数据库链接

CAS Registry No.	258279-04-8
UniProtKB	Q9UBU3
Wikipedia	Ghrelin
BindingDB Ligand	21940
PEP	ghrelin
Ensembl Gene	ENSG00000157017
GPCRdb Ligand	ghrelin

靶标

Target ID

246

名称

ghrelin receptor

缩写名

SHP2

家族

Ghrelin receptor

别名

α_1a/d-adrenoceptor

基因和蛋白信息

Species	Transmembrane Domains	Amino Acids	Chromosomal Location	Gene Symbol	Gene Name
Rat	7	364	2q24	Ghsr	growth hormone secretagogue receptor
Human	7	366	3q26.31	GHSR	growth hormone secretagogue receptor
Mouse	7	364	3 A3	Ghsr	growth hormone secretagogue receptor

RefSeq Protein

NP_114464 (Rn) , NP_940799 (Hs) , NP_796304 (Mm)

UniProtKB

O08725 (Rn) , Q92847 (Hs) , Q99P50 (Mm)

OMIM

601898 (Hs)

RefSeq Nucleotide

NM_198407 (Hs) , NM_032075 (Rn) , NM_177330 (Mm)

Entrez Gene

2693 (Hs) , 84022 (Rn) , 208188 (Mm)

Ensembl Gene

ENSG00000121853 (Hs) , ENSMUSG00000051136 (Mm) , ENSRNOG00000024119 (Rn)

Orphanet

201252 (Hs)

Protein GI

14140234 (Rn) , 28893445 (Mm) , 38455410 (Hs)

GPCRdb

ghsr_human (Hs) , ghsr_mouse (Mm) , ghsr_rat (Rn)

UniProtKB ID/Entry name

GHSR_HUMAN (Hs) , GHSR_MOUSE (Mm) , GHSR_RAT (Rn)

ChEMBL Target

CHEMBL3278 (Rn) , CHEMBL4616 (Hs) , CHEMBL3428 (Mm)

关联配体

Ligand ID

1099

名称

ghrelin

类别

Peptide

学名

4-amino-N-(4,6-dimethylpyrimidin-2-yl)benzenesulfonamide

生物活性评价

The sulfonamide class of antibacterial compounds are primarily bacteriostatic agents and have a broad spectrum of activity against both Gram-positive and Gram-negative species of bacteria (reviewed in ).

评价

There is some ambiguity in the literature and on other resources as to the exact chemical structure and stereochemistry of ghrelin. In the absence of a consensus chemical structure, we have chosen not to include an image of the molecule on this ligand entry. However, for representations of the structure please see these CHEBI:75431, CHEMBL425281 and PubChem CID 16133832 entries.

配体家族

Neuropeptides

基因/前体

Gene symbol	Gene name	Precursor protein name	Species	别名
GHRL	ghrelin and obestatin prepropeptide	prepro-appetite regulatory hormone	Human	MTLRP, ghrelin, obestatin, ghrelin, growth hormone secretagogue receptor ligand, ghrelin/obestatin prepropeptide

单字母多肽序列

GSSFLSPEHQRVQQRKESKKPPAKLQPR

三字母多肽序列

Gly-Ser-Ser(n-Octanoyl)-Phe-Leu-Ser-Pro-Glu-His-Gln-Arg-Val-Gln-Gln-Arg-Lys-Glu-Ser-Lys-Lys-Pro-Pro-Ala-Lys-Leu-Gln-Pro-Arg

翻译后修饰

The third residue, a serine, is octanoylated.

化学修饰

参考文献

1. Li C et al.. (2019) Defined Paraventricular Hypothalamic Populations Exhibit Differential Responses to Food Contingent on Caloric State.. Cell Metab, 29 (3): (681-694.e5). [PMID:30472090]
2. Alhashem F et al.. (2014) Exercise protects against obesity induced semen abnormalities via downregulating stem cell factor, upregulating Ghrelin and normalizing oxidative stress.. EXCLI J, 13 (): (551-72). [PMID:26417283]
3. Yu Y et al.. (2020) Ghrelin attenuates infectious bursal disease virus-induced early inflammatory response and bursal injury in chicken.. Poult Sci, 99 (11): (5399-5406). [PMID:33142456]
4. Miao H et al.. (2019) Ghrelin Promotes Proliferation and Inhibits Differentiation of 3T3-L1 and Human Primary Preadipocytes.. Front Physiol, 10 (): (1296). [PMID:31681009]