ghrelin receptor
Target Id | 246 |
---|---|
缩写名 | SHP2 |
家族 | Ghrelin receptor |
基因和蛋白信息
数据库链接
RefSeq Protein | NP_114464 (Rn) , NP_940799 (Hs) , NP_796304 (Mm) |
---|---|
UniProtKB | O08725 (Rn) , Q92847 (Hs) , Q99P50 (Mm) |
OMIM | 601898 (Hs) |
RefSeq Nucleotide | NM_198407 (Hs) , NM_032075 (Rn) , NM_177330 (Mm) |
Entrez Gene | 2693 (Hs) , 84022 (Rn) , 208188 (Mm) |
Ensembl Gene | ENSG00000121853 (Hs) , ENSMUSG00000051136 (Mm) , ENSRNOG00000024119 (Rn) |
Orphanet | 201252 (Hs) |
Protein GI | 14140234 (Rn) , 28893445 (Mm) , 38455410 (Hs) |
GPCRdb | ghsr_human (Hs) , ghsr_mouse (Mm) , ghsr_rat (Rn) |
UniProtKB ID/Entry name | GHSR_HUMAN (Hs) , GHSR_MOUSE (Mm) , GHSR_RAT (Rn) |
ChEMBL Target | CHEMBL3278 (Rn) , CHEMBL4616 (Hs) , CHEMBL3428 (Mm) |
作用于该靶标的配体
Ligand Id | Ligand | Ligand Type | Action on Target | 对应产品货号 |
---|---|---|---|---|
1092 | pralmorelin | Peptide | Full agonist | G416685 |
1093 | GHRP-6 | Peptide | Full agonist | rp174131 |
1094 | [125I][His9]ghrelin (human) | Peptide | Full agonist | rp175115 |
1094 | [125I][His9]ghrelin (human) | Peptide | Full agonist | rp175115 |
1095 | [125I]Tyr-Ala-hexarelin | Peptide | Full agonist | rp175181 |
1096 | [125I][Tyr4]ghrelin (human) | Peptide | Full agonist | rp175197 |
1097 | [35S]ibutamoren | Synthetic organic | Full agonist | S614032 |
1098 | [des-octanoyl]ghrelin | Peptide | Full agonist | D288226 |
1099 | ghrelin | Peptide | Full agonist | G111460 |
1100 | examorelin | Peptide | Full agonist | |
1101 | BIM 28163 | Peptide | Antagonist | rp173570 |
1099 | ghrelin | Peptide | Full agonist | G111460 |
1099 | ghrelin | Peptide | Full agonist | G111460 |
1099 | ghrelin | Peptide | Full agonist | G111460 |
1093 | GHRP-6 | Peptide | Full agonist | rp174131 |
1093 | GHRP-6 | Peptide | Full agonist | rp174131 |
1093 | GHRP-6 | Peptide | Full agonist | rp174131 |
5866 | SM-130,686 | Synthetic organic | Partial agonist | S613628 |
5866 | SM-130,686 | Synthetic organic | Partial agonist | S613628 |
5867 | ibutamoren | Synthetic organic | Full agonist | I610910 |
5867 | ibutamoren | Synthetic organic | Full agonist | I610910 |
5868 | L-692,429 | Synthetic organic | Agonist | L611396 |
5869 | wFw-Isn-NH2 | Peptide | Partial agonist | rp175397 |
1102 | [D-Arg1,D-Phe5,D-Trp7,9,Leu11]substance P | Peptide | Antagonist | rp173823 |
5870 | GSK1614343 | Synthetic organic | Antagonist | G610691 |
5871 | Abbott 14c | Synthetic organic | Antagonist | A607320 |
3538 | YIL781 | Synthetic organic | Antagonist | Y614914 |
5872 | JMV3008 | Synthetic organic | Antagonist | J611246 |
5868 | L-692,429 | Synthetic organic | Positive | L611396 |
5868 | L-692,429 | Synthetic organic | Agonist | L611396 |
5870 | GSK1614343 | Synthetic organic | Antagonist | G610691 |
9060 | PF-05190457 | Synthetic organic | Antagonist | P288410 |
9060 | PF-05190457 | Synthetic organic | Antagonist | P288410 |
9060 | PF-05190457 | Synthetic organic | Antagonist | P288410 |
9734 | liver enriched antimicrobial peptide 2 | Peptide | Antagonist | rp174464 |
1099 | ghrelin | Peptide | Full agonist | G111460 |
9745 | macimorelin | Synthetic organic | Agonist | M611718 |
10740 | HM01 | Synthetic organic | Agonist | H610848 |
12413 | PF-6870961 | Synthetic organic | Inverse agonist | P612758 |
12413 | PF-6870961 | Synthetic organic | Inverse agonist | P612758 |
参考文献
1. Bresnick JN, Skynner HA, Chapman KL, Jack AD, Zamiara E, Negulescu P, Beaumont K, Patel S, McAllister G. (2003) Identification of signal transduction pathways used by orphan g protein-coupled receptors.. Assay Drug Dev Technol, 1 (2): (239-49). [PMID:15090189] |