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N-甲酰-L-甲硫氨酰-L-白氨酰-L苯丙氨酸

有力的内源性趋化肽
规格或纯度: 97%
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货号 (SKU) 包装规格 是否现货 价格 数量
F113682-5mg 5mg 现货 Stock Image
F113682-10mg 10mg 现货 Stock Image
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F113682-50mg 50mg 现货 Stock Image
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FPR1 Agonist FPR2/ALX Agonist
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基本描述

规格或纯度 97%
英文名称 N-Formyl-Met-Leu-Phe
别名 N-甲酰-L-甲硫氨酰-L-亮氨酰-L-苯丙氨酸,趋化肽；fMLP；N-甲酰基-Met-Leu-Phe
英文别名 Chemotactic peptide fMLF fMLP (misnomer but widely used) N-Formyl-L-methionyl-L-leucyl-L-phenylalanine
生化机理 N-Formyl-Met-Leu-Phe induced chemotaxis in phosphoinositide 3-kinase γ (PI3K)γ-/- neutrophils, and promotes adhesion, polymerization of F-actin, Fcγ receptor-mediated phagocytosis and intracellular Ca2+ release. It acts as an inflammatory agent and activates polymorphonuclear leukocytes (PMNs) without the formation of 5-hydroxyicosatetraenoic acid (5-HETE) and leukotriene B4 (LTB4). Its effects on neutrophils and the inhibition of adenylate cyclase are inhibited by pertussis toxin. Potent chemotactic peptide. Induces a metabolic burst in macrophages accompanied by an increase in respiratory rate, secretion of lysosomal enzymes, and production of superoxide anion. Potent inducer of leucocyte chemotaxis and macrophage activator. Receptors that bind formylpeptides are found on phagocytic neutrophils and have recently been identified on cells of the intestinal mucosa.Potent endogenous chemotactic peptide and agonist for the formyl peptide receptor 1 (FPR1) (K i = 38 nM). Chemoattractant for phagocytic leukocytes. Stimulates random and directed locomotion. Inducer of superoxide release. Active in vitro .
应用 N-Formyl-Met-Leu-Phe has been used for: · creating gradients in Zigmond chamber chemotaxis assay performed on neutrophils · use in neutrophil chemotaix assayand · determination of the involvement of MAPK-activating protein kinase-2 (MAPKAPK-2) and/or p38, in the signaling pathway of human polymorphonuclear leukocytes (PMNs) stimulated by N-Formyl-Met-Leu-Phe.
储存温度 -20°C储存
运输条件 超低温冰袋运输
备注 如果有可能，您尽量在使用的当天配置溶液，并在当天使用完它。但是，如果您需要预先配制储备溶液，我们建议您将溶液等份保存在-20°C的密封小瓶中。通常，这些产品最多可以使用一周。在使用前和打开样品瓶之前，我们建议您让您的产品在室温下平衡至少1小时。需要更多关于溶解度，用法和处理的建议吗？请访问我们的常见问题（FAQ）页面以获取更多详细信息。
产品介绍

N-Formyl-Met-Leu-Phe has been used for:

· creating gradients in Zigmond chamber chemotaxis assay performed on neutrophils

· use in neutrophil chemotaix assayand

· determination of the involvement of MAPK-activating protein kinase-2 (MAPKAPK-2) and/or p38, in the signaling pathway of human polymorphonuclear leukocytes (PMNs) stimulated by N-Formyl-Met-Leu-Phe.

N-Formyl-Met-Leu-Phe has been used for:

· creating gradients in Zigmond chamber chemotaxis assay performed on neutrophils

· use in neutrophil chemotaix assayand

· determination of the involvement of MAPK-activating protein kinase-2 (MAPKAPK-2) and/or p38, in the signaling pathway of human polymorphonuclear leukocytes (PMNs) stimulated by N-Formyl-Met-Leu-Phe.

名称和标识符

IUPAC Name (2S)-2-[[(2S)-2-[[(2S)-2-formamido-4-methylsulfanylbutanoyl]amino]-4-methylpentanoyl]amino]-3-phenylpropanoic acid
INCHI InChI=1S/C21H31N3O5S/c1-14(2)11-17(23-19(26)16(22-13-25)9-10-30-3)20(27)24-18(21(28)29)12-15-7-5-4-6-8-15/h4-8,13-14,16-18H,9-12H2,1-3H3,(H,22,25)(H,23,26)(H,24,27)(H,28,29)/t16-,17-,18-/m0/s1
InChi Key PRQROPMIIGLWRP-BZSNNMDCSA-N
Canonical SMILES CC(C)CC(C(=O)NC(CC1=CC=CC=C1)C(=O)O)NC(=O)C(CCSC)NC=O
分子式

C21H31N3O5S
关联CAS 59880-97-6
UNII LO6AVJ8RCE
PubChem CID 443295
Beilstein号 2315783
分子量 437.55

化学和物理性质

敏感性 对热敏感
熔点 213 °C
比旋光度 -8° (C=1,AcOH)

安全信息

WGK Germany 3
个人防护装备 Eyeshields,Gloves,type N95 (US),type P1 (EN143) respirator filter

靶标

Target ID 222
名称 FPR1
缩写名 SHP2
家族 Formylpeptide receptors
基因和蛋白信息
Species Transmembrane Domains Amino Acids Chromosomal Location Gene Symbol Gene Name
Rat 7 355 1q12 Fpr1 formyl peptide receptor 1
Human 7 350 19q13.41 FPR1 formyl peptide receptor 1
Mouse 7 364 17 10.63 cM Fpr1 formyl peptide receptor 1
RefSeq Protein NP_001099686 (Rn) , NP_002020 (Hs) , NP_038549 (Mm)
UniProtKB P21462 (Hs) , P33766 (Mm)
OMIM 136537 (Hs)
RefSeq Nucleotide NM_002029 (Hs) , NM_001106216 (Rn) , NM_013521 (Mm)
Entrez Gene 2357 (Hs) , 292409 (Rn) , 14293 (Mm)
Ensembl Gene ENSG00000171051 (Hs) , ENSMUSG00000045551 (Mm) , ENSRNOG00000011174 (Rn)
Protein GI 300863094 (Hs) , 7305065 (Mm) , 157819173 (Rn)
GPCRdb fpr1_human (Hs) , fpr1_mouse (Mm)
UniProtKB ID/Entry name FPR1_HUMAN (Hs) , FPR1_MOUSE (Mm)
ChEMBL Target CHEMBL3359 (Hs) , CHEMBL1770037 (Mm)
Target ID 223
名称 FPR2/ALX
缩写名 SHP2
家族 Formylpeptide receptors
基因和蛋白信息
Species Transmembrane Domains Amino Acids Chromosomal Location Gene Symbol Gene Name
Rat 7 351 1q12 Fpr2 formyl peptide receptor 2
Human 7 351 19q13.41 FPR2 formyl peptide receptor 2
Mouse 7 351 17 A3.2 Fpr2 formyl peptide receptor 2
RefSeq Protein NP_001453 (Hs) , NP_032068 (Mm)
UniProtKB P25090 (Hs) , O88536 (Mm)
OMIM 136538 (Hs)
RefSeq Nucleotide NM_001462 (Hs) , NM_008042 (Mm)
Entrez Gene 2358 (Hs) , 690158 (Rn) , 14289 (Mm)
Ensembl Gene ENSG00000171049 (Hs) , ENSMUSG00000052270 (Mm) , ENSRNOG00000042605 (Rn)
Protein GI 6679853 (Mm) , 54112388 (Hs) , 109457930 (Rn)
GPCRdb fpr2_human (Hs) , fpr2_mouse (Mm)
UniProtKB ID/Entry name FPR2_HUMAN (Hs) , FPR2_MOUSE (Mm)
dbSNP rs56238033 (Hs) , rs1769490 (Hs)
ChEMBL Target CHEMBL4739842 (Mm) , CHEMBL4227 (Hs)

关联配体

Ligand ID 1022
名称 fMet-Leu-Phe
别名 fMetLeuPhe
类别 Peptide
学名 (2S)-2-[[(2S)-2-[[(2S)-2-formamido-4-methylsulfanylbutanoyl]amino]-4-methylpentanoyl]amino]-3-phenylpropanoic acid
生物活性评价 The sulfonamide class of antibacterial compounds are primarily bacteriostatic agents and have a broad spectrum of activity against both Gram-positive and Gram-negative species of bacteria (reviewed in ).
评价 From the bacterium E.coli
单字母多肽序列 MLP
三字母多肽序列 fMet-Leu-Phe
翻译后修饰
化学修饰 N-terminal residue is formyl-methionine

参考文献

1. Cuesta Torres LF et al..  (2019)  High-density lipoproteins induce miR-223-3p biogenesis and export from myeloid cells: Role of scavenger receptor BI-mediated lipid transfer..  Atherosclerosis,  286  ():  (20-29).  [PMID:31096070]

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