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EMD 386088 盐酸盐

强效的5-HT6激动剂

规格或纯度: ≥99%(HPLC)

CAS编号: 1171123-46-8
分子式: C₁₄H₁₅N₂Cl?HCl
分子量: 283.20
PubChem编号: 56972198

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货号 (SKU)	包装规格	是否现货
E288344-5mg	5mg	期货
E288344-10mg	10mg	期货
E288344-25mg	25mg	期货
E288344-50mg	50mg	期货
E288344-100mg	100mg	期货

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5-HT6 receptor Agonist

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基本描述

规格或纯度	≥99%(HPLC)
英文名称	EMD 386088 hydrochloride
别名	5-氯-2-甲基-3-(1,2,3,6-四氢-4-吡啶基)-1H-吲哚盐酸盐
英文别名	EMD 386088 HYDROCHLORIDE\|1171123-46-8\|EMD386088\|EMD386088Hydrochloride\|5-Chloro-2-methyl-3-(1,2,3,6-tetrahydropyridin-4-yl)-1H-indole hydrochloride\|5-Chloro-2-methyl-3-(1,2,3,6-tetrahydro-4-pyridinyl)-1H-Indole hydrochloride\|EMD 386088\|EMD386088 hydrochlo
生化机理	对5-HT6、5-HT1D，5-HT6、5-HT6受体激动剂（EC50 = 1.0 nM）表现出对其他5-HT受体（IC50值为7.4、110、180、240、450、620、660和3000 nM的选择性）的选择性HT1B，5-HT2A，5-HT2C，5-HT4、5-HT1A和5-HT7受体）。在5-HT3受体上显示中等亲和力（IC50 = 34 nM）。
储存温度	室温,干燥
运输条件	常规运输
产品介绍	EMD386088 是一种有效的5-羟色胺 6 受体 (5-HT6R) 激动剂。EMD386088 诱导细胞死亡。EMD386088 调节 ERK1/2 的活性。EMD386088具有研究阿尔茨海默病（AD）和精神分裂症的潜力 EMD386088 is a potent serotonin 6 receptor (5-HT6R) agonist. EMD386088 induced cell death. EMD386088 regulates the activity of ERK1/2. EMD386088 has the potential to study Alzheimer's disease (AD) and schizophrenia

名称和标识符

IUPAC Name	5-chloro-2-methyl-3-(1,2,3,6-tetrahydropyridin-4-yl)-1H-indole;hydrochloride
INCHI	InChI=1S/C14H15ClN2.ClH/c1-9-14(10-4-6-16-7-5-10)12-8-11(15)2-3-13(12)17-9;/h2-4,8,16-17H,5-7H2,1H3;1H
InChi Key	WWSNDUWIZDYGIQ-UHFFFAOYSA-N
Canonical SMILES	CC1=C(C2=C(N1)C=CC(=C2)Cl)C3=CCNCC3.Cl
分子式	C₁₄H₁₅N₂Cl?HCl
PubChem CID	56972198
分子量	283.20

数据库链接

CAS Registry No.	1171123-46-8
PubChem CID	10131112
ChEMBL Ligand	CHEMBL364005
GPCRdb Ligand	EMD-386088

化学和物理性质

溶解性	溶于water, 最高浓度 (mg/mL): 7.08, 最高浓度(mM): 25；溶于DMSO, 最高浓度 (mg/mL): 28.32, 最高浓度(mM): 100

安全信息

象形图	Toxic
信号词	Danger
危险声明	H301: Toxic if swallowed
预防措施声明	P321,P405,P501,P264,P270,P330,P301+P316
WGK Germany	3
RIDADR	UN28116.1/PGIII

靶标

Target ID

名称

5-HT₆ receptor

缩写名

SHP2

家族

5-Hydroxytryptamine receptors

别名

5-HT_1Dβ

基因和蛋白信息

Species	Transmembrane Domains	Amino Acids	Chromosomal Location	Gene Symbol	Gene Name
Rat	7	436	5q36	Htr6	5-hydroxytryptamine receptor 6
Human	7	440	1p36.13	HTR6	5-hydroxytryptamine receptor 6
Mouse	7	440	4 70.57 cM	Htr6	5-hydroxytryptamine (serotonin) receptor 6

RefSeq Protein

NP_077341 (Rn) , NP_000862 (Hs) , NP_067333 (Mm)

UniProtKB

P31388 (Rn) , P50406 (Hs) , Q9R1C8 (Mm)

OMIM

601109 (Hs)

RefSeq Nucleotide

NM_000871 (Hs) , NM_024365 (Rn) , NM_021358 (Mm)

Entrez Gene

3362 (Hs) , 64354 (Rn) , 15565 (Mm)

Ensembl Gene

ENSG00000158748 (Hs) , ENSMUSG00000028747 (Mm) , ENSRNOG00000049761 (Rn)

Protein GI

816197606 (Rn) , 10946684 (Mm) , 4504545 (Hs)

GPCRdb

5ht6r_human (Hs) , 5ht6r_mouse (Mm) , 5ht6r_rat (Rn)

UniProtKB ID/Entry name

5HT6R_HUMAN (Hs) , 5HT6R_MOUSE (Mm) , 5HT6R_RAT (Rn)

DrugBank Target

P50406 (Hs)

ChEMBL Target

CHEMBL1075268 (Mm) , CHEMBL3372 (Rn) , CHEMBL3371 (Hs)

关联配体

Ligand ID	8428
名称	EMD-386088
别名	compound 18 [PMID 16055331]
类别	Synthetic organic
学名	5-chloro-2-methyl-3-(1,2,3,6-tetrahydropyridin-4-yl)-1H-indole
生物活性评价	The pharmacological profile of EMD 386088 across 5-HT receptor subtypes is provided by Mattson et al. (2005; Table 4) .
评价	This compound was discovered as the result of a medicinal chemistry programme directed towards the design and synthesis of new tool compounds which are potent and selective 5-HT₆ receptor agonists . Such a tool compound could be used to investigate the in vivo functional role of 5-HT₆ receptors.

参考文献

1. Mattsson C, Sonesson C, Sandahl A, Greiner HE, Gassen M, Plaschke J, Leibrock J, B?ttcher H. (2005) 2-Alkyl-3-(1,2,3,6-tetrahydropyridin-4-yl)-1H-indoles as novel 5-HT6 receptor agonists.. Bioorg Med Chem Lett, 15 (19): (4230-4). [PMID:16055331]