Species	Transmembrane Domains	Amino Acids	Chromosomal Location	Gene Symbol	Gene Name
Rat	7	436	5q36	Htr6	5-hydroxytryptamine receptor 6
Human	7	440	1p36.13	HTR6	5-hydroxytryptamine receptor 6
Mouse	7	440	4 70.57 cM	Htr6	5-hydroxytryptamine (serotonin) receptor 6

RefSeq Protein	NP_077341 (Rn) , NP_000862 (Hs) , NP_067333 (Mm)
UniProtKB	P31388 (Rn) , P50406 (Hs) , Q9R1C8 (Mm)
OMIM	601109 (Hs)
RefSeq Nucleotide	NM_000871 (Hs) , NM_024365 (Rn) , NM_021358 (Mm)
Entrez Gene	3362 (Hs) , 64354 (Rn) , 15565 (Mm)
Ensembl Gene	ENSG00000158748 (Hs) , ENSMUSG00000028747 (Mm) , ENSRNOG00000049761 (Rn)
Protein GI	816197606 (Rn) , 10946684 (Mm) , 4504545 (Hs)
GPCRdb	5ht6r_human (Hs) , 5ht6r_mouse (Mm) , 5ht6r_rat (Rn)
UniProtKB ID/Entry name	5HT6R_HUMAN (Hs) , 5HT6R_MOUSE (Mm) , 5HT6R_RAT (Rn)
DrugBank Target	P50406 (Hs)
ChEMBL Target	CHEMBL1075268 (Mm) , CHEMBL3372 (Rn) , CHEMBL3371 (Hs)

Ligand Id	Ligand	Ligand Type	Action on Target	对应产品货号	产品名称
152	α-methyl-5-HT	Synthetic organic	Full agonist	A338115	（±）α-甲基5-羟色胺马来酸酯
3	1-naphthylpiperazine	Synthetic organic	Full agonist	N335877	1-(1-萘)哌嗪
218	2-methyl-5-HT	Synthetic organic	Full agonist	M336035	2-甲基5-羟色胺盐酸盐
4	5-CT	Synthetic organic	Full agonist	C337890	5-羧酰胺基马来酸
4	5-CT	Synthetic organic	Full agonist	C337890	5-羧酰胺基马来酸
5	5-hydroxytryptamine	Metabolite	Full agonist	H303833	5-羟基色胺
5	5-hydroxytryptamine	Metabolite	Full agonist	H303833	5-羟基色胺
145	5-MeO-DMT	Synthetic organic	Full agonist
107	5-MeOT	Synthetic organic	Full agonist	M124574	5-甲氧基色胺
107	5-MeOT	Synthetic organic	Full agonist	M124574	5-甲氧基色胺
265	5-benzyloxytryptamine	Synthetic organic	Full agonist	B607209	5-benzyloxytryptamine
142	m-chlorophenylpiperazine	Synthetic organic	Full agonist	C346364	(禁售)(停产)1-（3-氯苯基）哌嗪
10	BRL-15572	Synthetic organic	Partial agonist	B129690	BRL-15572,h5-HT1D拮抗剂
109	CGS-12066	Synthetic organic	Full agonist	C608513	CGS-12066
267	DM-1451	Synthetic organic	Full agonist	D609926	DM-1451
12	EMDT	Synthetic organic	Full agonist	E335534	草酸EMDT
14	GR 127935	Synthetic organic	Partial agonist	G610638	GR 127935
17	Lysergide	Synthetic organic	Full agonist	L611684	Lysergide
17	Lysergide	Synthetic organic	Full agonist	L611684	Lysergide
18	LY 165,163	Synthetic organic	Full agonist	L336143	LY-165,163
268	OPC 4392	Synthetic organic	Full agonist	O612539	OPC 4392
23	RU 24969	Synthetic organic	Full agonist	M352444	5-甲氧基-3-（1,2,3,6-四氢吡啶-4-基）-1H-吲哚
167	S 16924	Synthetic organic	Full agonist	S613356	S 16924
29	capeserod	Synthetic organic	Partial agonist	C608315	capeserod
115	TFMPP	Synthetic organic	Full agonist
115	TFMPP	Synthetic organic	Full agonist
5	5-hydroxytryptamine	Metabolite	Full agonist	H303833	5-羟基色胺
219	[3H]LSD	Synthetic organic	Full agonist	H614155	[3H]LSD
219	[3H]LSD	Synthetic organic	Full agonist	H614155	[3H]LSD
34	aripiprazole	Synthetic organic	Antagonist	A124880	阿立哌唑
35	bromocriptine	Synthetic organic	Partial agonist	B333470	溴隐亭
35	bromocriptine	Synthetic organic	Full agonist	B333470	溴隐亭
141	dimethyltryptamine	Synthetic organic	Full agonist	D609899	dimethyltryptamine
39	donitriptan	Synthetic organic	Partial agonist	D609948	donitriptan
149	ergotamine	Synthetic organic	Full agonist	E610174	ergotamine
149	ergotamine	Synthetic organic	Full agonist	E610174	ergotamine
270	lergotrile	Synthetic organic	Full agonist	L611489	lergotrile
43	lisuride	Natural product	Partial agonist	L353949	麦角乙脲
43	lisuride	Natural product	Partial agonist	L353949	麦角乙脲
48	pergolide	Natural product	Full agonist	P160441	培高利特
125	tryptamine	Metabolite	Full agonist	T101154	色胺
57	xanomeline	Synthetic organic	Full agonist	X614889	xanomeline
271	α-ergocryptine	Natural product	Antagonist	E607542	α-ergocryptine
272	2-bromo-LSD	Synthetic organic	Antagonist	B607110	2-bromo-LSD
273	ICI 169369	Synthetic organic	Antagonist	I610922	ICI 169369
71	MPDT	Synthetic organic	Antagonist	B288458	BGC 20-761,5-HT6拮抗剂
274	Ro 04-6790	Synthetic organic	Antagonist	R287773	Ro 04-6790,5-HT6拮抗剂
274	Ro 04-6790	Synthetic organic	Antagonist	R287773	Ro 04-6790,5-HT6拮抗剂
275	Ro 63-0563	Synthetic organic	Antagonist	R613257	Ro 63-0563
275	Ro 63-0563	Synthetic organic	Antagonist	R613257	Ro 63-0563
276	SB 271046	Synthetic organic	Antagonist	S129774	SB271046
200	amitriptyline	Synthetic organic	Antagonist	A413377	阿米替林
200	amitriptyline	Synthetic organic	Antagonist	A413377	阿米替林
201	amoxapine	Synthetic organic	Antagonist	A129596	阿莫沙平
201	amoxapine	Synthetic organic	Antagonist	A129596	阿莫沙平
144	bufotenine	Synthetic organic	Antagonist	B608247	bufotenine
83	chlorpromazine	Synthetic organic	Inverse agonist	C184839	氯丙嗪
83	chlorpromazine	Synthetic organic	Inverse agonist	C184839	氯丙嗪
38	clozapine	Synthetic organic	Inverse agonist	C126883	氯氮平
38	clozapine	Synthetic organic	Inverse agonist	C126883	氯氮平
277	cyproheptadine	Synthetic organic	Antagonist	C609703	cyproheptadine
277	cyproheptadine	Synthetic organic	Antagonist	C609703	cyproheptadine
278	dihydroergocristine	Natural product	Antagonist
121	dihydroergotamine	Synthetic organic	Antagonist	D135863	双氢麦角胺甲磺酸盐
202	duloxetine	Synthetic organic	Antagonist	D342246	度洛西汀
203	fluoxetine	Synthetic organic	Antagonist	F189157	氟西汀
279	fluperlapine	Synthetic organic	Inverse agonist	F336050	Fluperlapine
279	fluperlapine	Synthetic organic	Inverse agonist	F336050	Fluperlapine
204	fluphenazine	Synthetic organic	Inverse agonist	F304408	Fluphenazine
204	fluphenazine	Synthetic organic	Inverse agonist	F304408	Fluphenazine
87	iloperidone	Synthetic organic	Antagonist	I125279	伊潘立酮
87	iloperidone	Synthetic organic	Antagonist	I125279	伊潘立酮
205	loxapine	Synthetic organic	Inverse agonist	L126648	洛沙平
205	loxapine	Synthetic organic	Inverse agonist	L126648	洛沙平
206	mesulergine	Synthetic organic	Antagonist	M338134	盐酸甲磺麦角碱
206	mesulergine	Synthetic organic	Antagonist	M338134	盐酸甲磺麦角碱
133	metergoline	Synthetic organic	Antagonist
133	metergoline	Synthetic organic	Antagonist
89	methiothepin	Synthetic organic	Antagonist	M611817	methiothepin
89	methiothepin	Synthetic organic	Antagonist	M611817	methiothepin
134	methysergide	Synthetic organic	Antagonist	M611839	methysergide
134	methysergide	Synthetic organic	Antagonist	M611839	methysergide
135	mianserin	Synthetic organic	Antagonist	M611864	mianserin
135	mianserin	Synthetic organic	Antagonist	M611864	mianserin
47	olanzapine	Synthetic organic	Inverse agonist	O126519	奥氮平
47	olanzapine	Synthetic organic	Inverse agonist	O126519	奥氮平
209	perphenazine	Synthetic organic	Inverse agonist	P160649	奋乃静
209	perphenazine	Synthetic organic	Inverse agonist	P160649	奋乃静
90	pimozide	Synthetic organic	Antagonist	P275736	匹莫齐特
96	risperidone	Synthetic organic	Inverse agonist	R127644	利哌酮
96	risperidone	Synthetic organic	Antagonist	R127644	利哌酮
97	ritanserin	Synthetic organic	Antagonist
97	ritanserin	Synthetic organic	Antagonist
99	spiperone	Synthetic organic	Antagonist
54	sumatriptan	Synthetic organic	Antagonist	S333476	苏门曲普坦
54	sumatriptan	Synthetic organic	Antagonist	S333476	苏门曲普坦
100	thioridazine	Synthetic organic	Inverse agonist	T614426	thioridazine
100	thioridazine	Synthetic organic	Inverse agonist	T614426	thioridazine
101	tiospirone	Synthetic organic	Antagonist	T614467	tiospirone
101	tiospirone	Synthetic organic	Antagonist	T614467	tiospirone
103	zotepine	Synthetic organic	Inverse agonist	Z132909	佐替平
103	zotepine	Synthetic organic	Inverse agonist	Z132909	佐替平
3217	E6801	Synthetic organic	Partial agonist	E610046	E6801
3240	WAY-181187	Synthetic organic	Agonist	W614832	WAY-181187
3241	SB399885	Synthetic organic	Antagonist	S275660	SB 399885盐酸盐
3245	[125I]SB258585	Synthetic organic	Antagonist	S613962	[12?I]SB258585
3246	[3H]Ro 63-0563	Synthetic organic	Antagonist
262	[3H]5-CT	Synthetic organic	Agonist	H614039	[3H]5-CT
3235	SB357134	Synthetic organic	Antagonist	S613457	SB357134
7356	cerlapirdine	Synthetic organic	Antagonist	C608479	cerlapirdine
7351	vortioxetine	Synthetic organic	Antagonist	V125545	沃替西汀
3232	SB258585	Synthetic organic	Antagonist	S337673	SB 258585盐酸盐
8428	EMD-386088	Synthetic organic	Agonist	E288344	EMD 386088 盐酸盐
8429	WAY-208466	Synthetic organic	Agonist	W332774	WAY 208466二盐酸盐
8430	[11C]GSK215083	Synthetic organic	Antagonist	C613771	[11C]GSK215083
8689	idalopirdine	Synthetic organic	Antagonist	I610935	idalopirdine
9444	intepirdine	Synthetic organic	Antagonist	S127746	SB742457,且5-HT6拮抗剂

1. Lovenberg TW, Erlander MG, Baron BM, Racke M, Slone AL, Siegel BW, Craft CM, Burns JE, Danielson PE, Sutcliffe JG.  (1993)  Molecular cloning and functional expression of 5-HT1E-like rat and human 5-hydroxytryptamine receptor genes..  Proc Natl Acad Sci USA,  90  (6):  (2184-8).  [PMID:8384716]