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2-(2,6-二氯苯氨基)苯乙酸

规格或纯度: >98.0%
  • CAS编号: 15307-86-5
  • 分子式: C14H11Cl2NO2
  • 分子量: 296.15
  • PubChem编号: 3033
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货号 (SKU) 包装规格 是否现货 价格 数量
D155733-1g
1g 现货 Stock Image
D155733-5g
5g 现货 Stock Image
D155733-25g
25g 现货 Stock Image
D155733-100g
100g 现货 Stock Image
D155733-500g
500g 现货 Stock Image

基本描述

规格或纯度 >98.0%
英文名称 Diclofenac
别名 双氯芬酸|奥尔芬
英文别名 diclofenac|Diclofenac acid|15307-86-5|dichlofenac|Diclofenacum|Diclophenac|Diclofenaco|ProSorb-D|2-(2-((2,6-Dichlorophenyl)amino)phenyl)acetic acid|Diclofenac resinate|Voltarol|Diclofenac free acid|2-(2,6-Dichloroanilino)phenylacetic Acid|Zorovolex|Zorvol
储存温度 2-8°C储存
运输条件 冰袋运输
产品介绍

Diclofenac is a non-selective COX inhibitor with IC50 of 60 and 220 nM for ovine COX-1 and -2, respectively. Target: COX Diclofenac is a nonsteroidal anti-inflammatory drμg (NSAID) taken or applied to reduce inflammation and as an analgesic reducing pain in certain conditions. The primary mechanism responsible for its anti-inflammatory, antipyretic, and analgesic action is thoμght to be inhibition of prostaglandin synthesis by inhibition of cyclooxygenase (COX). It also appears to exhibit bacteriostatic activity by inhibiting bacterial DNA synthesis. Inhibition of COX also decreases prostaglandins in the epithelium of the stomach, making it more sensitive to corrosion by gastric acid. This is also the main side effect of diclofenac. Diclofenac has a low to moderate preference to block the COX2-isoenzyme and is said to have, therefore, a somewhat lower incidence of gastrointestinal complaints than noted with indomethacin and aspirin.

Diclofenac (双氯芬酸) 是COX抑制剂,对绵羊的COX-1和-2的IC50分别为60和220 nM。

Diclofenac is a non-selective COX inhibitor with IC50 of 60 and 220 nM for ovine COX-1 and -2, respectively. Target: COX Diclofenac is a nonsteroidal anti-inflammatory drug (NSAID) taken or applied to reduce inflammation and as an analgesic reducing pain in certain conditions. The primary mechanism responsible for its anti-inflammatory, antipyretic, and analgesic action is thought to be inhibition of prostaglandin synthesis by inhibition of cyclooxygenase (COX). It also appears to exhibit bacteriostatic activity by inhibiting bacterial DNA synthesis. Inhibition of COX also decreases prostaglandins in the epithelium of the stomach, making it more sensitive to corrosion by gastric acid. This is also the main side effect of diclofenac. Diclofenac has a low to moderate preference to block the COX2-isoenzyme and is said to have, therefore, a somewhat lower incidence of gastrointestinal complaints than noted with indomethacin and aspirin.

Diclofenac acid is a nonsteroidal anti-inflammatory compound and decycloxygenase (COX) inhibitor.

名称和标识符

IUPAC Name 2-[2-(2,6-dichloroanilino)phenyl]acetic acid
INCHI InChI=1S/C14H11Cl2NO2/c15-10-5-3-6-11(16)14(10)17-12-7-2-1-4-9(12)8-13(18)19/h1-7,17H,8H2,(H,18,19)
InChi Key DCOPUUMXTXDBNB-UHFFFAOYSA-N
Canonical SMILES C1=CC=C(C(=C1)CC(=O)O)NC2=C(C=CC=C2Cl)Cl
RTECS AG6310000
PubChem CID 3033
分子量 296.15
Reaxy-Rn 2146636

化学和物理性质

溶解性 Chloroform (Slightly, Heated), Methanol (Slightly)
熔点 158°C

安全和危险性(GHS)

象形图
ghs06

Toxic

ghs08

Health Hazard

ghs09

Environmental Hazard

信号词 Danger
危险声明 H301: Toxic if swallowed
H411: Toxic to aquatic life with long lasting effects
H372: Causes damage to organs through prolonged or repeated exposure
H361: Suspected of damaging fertility or the unborn child
预防措施声明 P273,P280,P264,P260,P201,P308+P313,P270,P391,P202,P301+P310+P330
RTECS AG6310000
Reaxy-Rn 2146636
Merck Index 3081

关联配体

Ligand ID 2714
名称 diclofenac
别名 Cataflam®
类别 Synthetic organic
学名 2-[2-[(2,6-dichlorophenyl)amino]phenyl]acetic acid
生物活性评价 The sulfonamide class of antibacterial compounds are primarily bacteriostatic agents and have a broad spectrum of activity against both Gram-positive and Gram-negative species of bacteria (reviewed in ).
评价 Diclofenac is a nonsteroidal anti-inflammatory drug (NSAID)
配体家族 Non-steroidal anti-inflammatory ligands

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