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diclofenac
| 别名 | Cataflam®, Voltaren®, Voltarol®, CGP-45840B, GP-45840 |
|---|---|
| Compound Class | Synthetic organic |
| 变动原因 | Diclofenac is a nonsteroidal anti-inflammatory drug (NSAID) |
| Related Product | 2-(2,6-二氯苯氨基)苯乙酸 |
Summary
| 是否批准为药物？ | (FDA (1988)) |
|---|---|
| IUPAC Name | 2-[2-[(2,6-dichlorophenyl)amino]phenyl]acetic acid |
| 别名 | Cataflam®, Voltaren®, Voltarol®, CGP-45840B, GP-45840 |
数据库链接
| PubChem CID | 3033 |
|---|---|
| DrugBank Ligand | DB00586 |
| CAS Registry No. | 15307-86-5 |
| ChEBI | CHEBI:47381 |
| ChEMBL Ligand | CHEMBL139 |
| BindingDB Ligand | 13066 |
| Wikipedia | Diclofenac |
| BitterDB Ligand | 942 |
| RCSB PDB Ligand | DIF |
| PEP | diclofenac |
| DrugCentral Ligand | 865 |
生物活性
| 生物活性评价 |
The sulfonamide class of antibacterial compounds are primarily bacteriostatic agents and have a broad spectrum of activity against both Gram-positive and Gram-negative species of bacteria (reviewed in |
|---|---|
| 关联靶标 | Peroxisome proliferator-activated receptor-γ , Peroxisome proliferator-activated receptor-γ , ASIC3 , COX-1 , COX-2 , TRPM3 |
临床资料
| Summary of Clinical Use | Diclofenac is used to treat pain or inflammation caused by osteoarthritis and rheumatoid arthritis, but is also used to treat other conditions which benefit from the analgesic and antipyretic properties of NSAIDs. |
|---|---|
| 作用机制与药效学效应 | In addition to inhibiting prostaglandin synthesis (via inhibition of COX-1 and COX-2; prostaglandins normally sensitize nociceptors), diclofenac appears to inhibit leukocyte migration at inflammarory sites. |
结构
| Canonical SMILES | OC(=O)Cc1ccccc1Nc1c(Cl)cccc1Cl |
|---|---|
| Isomeric SMILES | OC(=O)Cc1ccccc1Nc1c(Cl)cccc1Cl |
| InChI | InChI=1S/C14H11Cl2NO2/c15-10-5-3-6-11(16)14(10)17-12-7-2-1-4-9(12)8-13(18)19/h1-7,17H,8H2,(H,18,19) |
| InChI key | DCOPUUMXTXDBNB-UHFFFAOYSA-N |
危险品化学品经营许可证（带存储）