Cas(122384-88-7), 糖尿病相关肽(胰岛淀粉样肽)-阿拉丁试剂, Amylin, DAP, IAPP,Diabetes Associated Peptide Amide human,

货号 (SKU)	包装规格	是否现货	价格	数量
D118757-1mg	1mg	现货
D118757-5mg	5mg	现货

基本描述

规格或纯度	≥97% (HPLC)
英文名称	Diabetes Associated Peptide Amide human
别名	Amylin, DAP, IAPP
英文别名	Amylin, DAP, IAPP, Insulinoma or Islet amyloid polypeptide
生化机理	胰岛淀粉样多肽（IAPP）是一种胰岛素的胰腺β-细胞表达的激素。 IAPP用来研究淀粉样蛋白沉积的作用机制以及对分子的错误折叠的过程的作用，特别是在II型糖尿病等条件下。内源性肽。强大的胰岛淀粉样多肽，降钙素（EC 50 = 0.67 nM），CGRP和肾上腺髓质素受体激动剂。有效抑制骨骼肌细胞中胰岛素刺激的葡萄糖摄取（IC 50 = 12 pM）。涉及II型糖尿病。
储存温度	-20°C储存
运输条件	超低温冰袋运输
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产品介绍	氨基酸序列 Lys-Cys-Asn-Thr-Ala-Thr-C?ys-Ala-Thr-Gln-Arg-Leu-Al?a-Asn-Phe-Leu-Val-His-Ser?-Ser-Asn-Asn-Phe-Gly-Ala-?Ile-Leu-Ser-Ser-Thr-Asn-V?al-Gly-Ser-Asn-Thr-Tyr-NH?2 Amino Acid Sequence Lys-Cys-Asn-Thr-Ala-Thr-C?ys-Ala-Thr-Gln-Arg-Leu-Al?a-Asn-Phe-Leu-Val-His-Ser?-Ser-Asn-Asn-Phe-Gly-Ala-?Ile-Leu-Ser-Ser-Thr-Asn-V?al-Gly-Ser-Asn-Thr-Tyr-NH?2

名称和标识符

IUPAC Name	N-[1-[[1-[[1-[[4-amino-1-[[1-[[1-[[1-[[1-[[1-[[1-[[4-amino-1-[[4-amino-1-[[1-[[2-[[1-[[1-[[1-[[1-[[1-[[1-[[4-amino-1-[[1-[[2-[[1-[[4-amino-1-[[1-[[1-amino-3-(4-hydroxyphenyl)-1-oxopropan-2-yl]amino]-3-hydroxy-1-oxobutan-2-yl]amino]-1,4-dioxobutan-2-yl]amino]-3-hydroxy-1-oxopropan-2-yl]amino]-2-oxoethyl]amino]-3-methyl-1-oxobutan-2-yl]amino]-1,4-dioxobutan-2-yl]amino]-3-hydroxy-1-oxobutan-2-yl]amino]-3-hydroxy-1-oxopropan-2-yl]amino]-3-hydroxy-1-oxopropan-2-yl]amino]-4-methyl-1-oxopentan-2-yl]amino]-3-methyl-1-oxopentan-2-yl]amino]-1-oxopropan-2-yl]amino]-2-oxoethyl]amino]-1-oxo-3-phenylpropan-2-yl]amino]-1,4-dioxobutan-2-yl]amino]-1,4-dioxobutan-2-yl]amino]-3-hydroxy-1-oxopropan-2-yl]amino]-3-hydroxy-1-oxopropan-2-yl]amino]-3-(1H-imidazol-5-yl)-1-oxopropan-2-yl]amino]-3-methyl-1-oxobutan-2-yl]amino]-4-methyl-1-oxopentan-2-yl]amino]-1-oxo-3-phenylpropan-2-yl]amino]-1,4-dioxobutan-2-yl]amino]-1-oxopropan-2-yl]amino]-4-methyl-1-oxopentan-2-yl]amino]-5-carbamimidamido-1-oxopentan-2-yl]-2-[[2-[2-[[16-(2-amino-2-oxoethyl)-19-(2,6-diaminohexanoylamino)-7,13-bis(1-hydroxyethyl)-10-methyl-6,9,12,15,18-pentaoxo-1,2-dithia-5,8,11,14,17-pentazacycloicosane-4-carbonyl]amino]propanoylamino]-3-hydroxybutanoyl]amino]pentanediamide
INCHI	InChI=1S/C165H261N51O55S2/c1-22-75(12)124(159(266)200-95(47-71(4)5)140(247)203-108(64-219)153(260)206-110(66-221)154(261)216-129(84(21)226)163(270)202-105(58-119(174)234)147(254)209-122(73(8)9)157(264)181-61-121(236)187-106(62-217)150(257)198-103(56-117(172)232)148(255)215-128(83(20)225)162(269)190-93(130(175)237)49-87-38-40-89(227)41-39-87)211-132(239)76(13)183-120(235)60-180-136(243)97(50-85-32-25-23-26-33-85)194-144(251)101(54-115(170)230)196-145(252)102(55-116(171)231)197-151(258)107(63-218)205-152(259)109(65-220)204-142(249)99(52-88-59-178-69-182-88)201-158(265)123(74(10)11)210-146(253)96(48-72(6)7)193-141(248)98(51-86-34-27-24-28-35-86)195-143(250)100(53-114(169)229)191-131(238)77(14)184-139(246)94(46-70(2)3)192-137(244)91(37-31-45-179-165(176)177)188-138(245)92(42-43-113(168)228)189-161(268)126(81(18)223)212-133(240)78(15)185-155(262)111-67-272-273-68-112(207-135(242)90(167)36-29-30-44-166)156(263)199-104(57-118(173)233)149(256)214-125(80(17)222)160(267)186-79(16)134(241)213-127(82(19)224)164(271)208-111/h23-28,32-35,38-41,59,69-84,90-112,122-129,217-227H,22,29-31,36-37,42-58,60-68,166-167H2,1-21H3,(H2,168,228)(H2,169,229)(H2,170,230)(H2,171,231)(H2,172,232)(H2,173,233)(H2,174,234)(H2,175,237)(H,178,182)(H,180,243)(H,181,264)(H,183,235)(H,184,246)(H,185,262)(H,186,267)(H,187,236)(H,188,245)(H,189,268)(H,190,269)(H,191,238)(H,192,244)(H,193,248)(H,194,251)(H,195,250)(H,196,252)(H,197,258)(H,198,257)(H,199,263)(H,200,266)(H,201,265)(H,202,270)(H,203,247)(H,204,249)(H,205,259)(H,206,260)(H,207,242)(H,208,271)(H,209,254)(H,210,253)(H,211,239)(H,212,240)(H,213,241)(H,214,256)(H,215,255)(H,216,261)(H4,176,177,179)
InChi Key	PLOPBXQQPZYQFA-UHFFFAOYSA-N
Canonical SMILES	CCC(C)C(C(=O)NC(CC(C)C)C(=O)NC(CO)C(=O)NC(CO)C(=O)NC(C(C)O)C(=O)NC(CC(=O)N)C(=O)NC(C(C)C)C(=O)NCC(=O)NC(CO)C(=O)NC(CC(=O)N)C(=O)NC(C(C)O)C(=O)NC(CC1=CC=C(C=C1)O)C(=O)N)NC(=O)C(C)NC(=O)CNC(=O)C(CC2=CC=CC=C2)NC(=O)C(CC(=O)N)NC(=O)C(CC(=O)N)NC(=O)C(CO)NC(=O)C(CO)NC(=O)C(CC3=CN=CN3)NC(=O)C(C(C)C)NC(=O)C(CC(C)C)NC(=O)C(CC4=CC=CC=C4)NC(=O)C(CC(=O)N)NC(=O)C(C)NC(=O)C(CC(C)C)NC(=O)C(CCCNC(=N)N)NC(=O)C(CCC(=O)N)NC(=O)C(C(C)O)NC(=O)C(C)NC(=O)C5CSSCC(C(=O)NC(C(=O)NC(C(=O)NC(C(=O)NC(C(=O)N5)C(C)O)C)C(C)O)CC(=O)N)NC(=O)C(CCCCN)N
分子式	C₁₆₅H₂₆₁N₅₁O₅₅S₂
PubChem CID	16158170
分子量	3903.28

数据库链接

UniProtKB	P10997
CAS Registry No.	122384-88-7
Ensembl Gene	ENSG00000121351
Entrez Gene	3375
Wikipedia	Amylin
GPCRdb Ligand	amylin

安全信息

WGK Germany	3
个人防护装备	Eyeshields, Gloves, type N95 (US), type P1 (EN143) respirator filter

靶标

Target ID

43

名称

CT receptor

缩写名

SHP2

家族

Calcitonin receptors

基因和蛋白信息

Species	Transmembrane Domains	Amino Acids	Chromosomal Location	Gene Symbol	Gene Name
Rat	7	516	4q13	Calcr	calcitonin receptor
Human	7	474	7q21.3	CALCR	calcitonin receptor
Mouse	7	533	6 1.81 cM	Calcr	calcitonin receptor

RefSeq Protein

NP_001029187 (Rn) , NP_446268 (Rn) , NP_001733 (Hs) , NP_031614 (Mm) , NP_001158209 (Hs)

UniProtKB

P32214 (Rn) , P30988 (Hs) , Q60755 (Mm)

OMIM

114131 (Hs)

RefSeq Nucleotide

NM_001742 (Hs) , NM_001034015 (Rn) , NM_053816 (Rn) , NM_007588 (Mm)

Entrez Gene

799 (Hs) , 116506 (Rn) , 12311 (Mm)

Ensembl Gene

ENSG00000004948 (Hs) , ENSMUSG00000023964 (Mm) , ENSRNOG00000010053 (Rn)

Protein GI

77404387 (Rn) , 112181179 (Mm) , 260064027 (Hs)

GPCRdb

calcr_human (Hs) , calcr_mouse (Mm) , calcr_rat (Rn)

UniProtKB ID/Entry name

CALCR_HUMAN (Hs) , CALCR_MOUSE (Mm) , CALCR_RAT (Rn)

DrugBank Target

P30988 (Hs)

CATH/Gene3D

4.10.1240.10 (N/A)

ChEMBL Target

CHEMBL2204 (Rn) , CHEMBL1832 (Hs)

Target ID	44
名称	AMY₁ receptor
缩写名	SHP2
家族	Calcitonin receptors

Target ID	45
名称	AMY₂ receptor
缩写名	SHP2
家族	Calcitonin receptors

Target ID	46
名称	AMY₃ receptor
缩写名	SHP2
家族	Calcitonin receptors

关联配体

Ligand ID

687

名称

amylin

类别

Peptide

学名

4-amino-N-(4,6-dimethylpyrimidin-2-yl)benzenesulfonamide

生物活性评价

The sulfonamide class of antibacterial compounds are primarily bacteriostatic agents and have a broad spectrum of activity against both Gram-positive and Gram-negative species of bacteria (reviewed in ).

评价

Amylin acts as an appetite suppressor. Novo Nordisk have a long-acting amylin mimetic (AM833, NNC0174-0833) in clinical trials with and without . AM833 is intended as a treatment for obesity. In the trials it is administered subcutaneously, once-weekly. Preliminary (and as yet unpublished) results from a Phase 2 trial as monotherapy demonstrated weight loss of 10.8% at week 26, meeting the study's primary endpoint (Novo Nordisk press release 18 Jun 2020).

配体家族

Neuropeptides

基因/前体

Gene symbol	Gene name	Precursor protein name	Species	别名
IAPP	islet amyloid polypeptide	pre-pro-IAPP	Human	DAP, IAP

单字母多肽序列

KCNTATCATQRLANFLVHSSNNFGAILSSTNVGSNTY

三字母多肽序列

Lys-Cys-Asn-Thr-Ala-Thr-Cys-Ala-Thr-Gln-Arg-Leu-Ala-Asn-Phe-Leu-Val-His-Ser-Ser-Asn-Asn-Phe-Gly-Ala-Ile-Leu-Ser-Ser-Thr-Asn-Val-Gly-Ser-Asn-Thr-Tyr-NH2

翻译后修饰

The C-terminal proline is amidated into Pro-NH2 and a disulphide bridge is formed between cysteine residues at positions 2 and 7.

化学修饰

参考文献

1. Majumder P et al.. (2021) A nexus of miR-1271, PAX4 and ALK/RYK influences the cytoskeletal architectures in Alzheimer's Disease and Type 2 Diabetes.. Biochem J, 478 (17): (3297-3317). [PMID:34409981]
2. Majumder P et al.. (2019) Receptor tyrosine kinases (RTKs) consociate in regulatory clusters in Alzheimer's disease and type 2 diabetes.. Mol Cell Biochem, 459 (1-2): (171-182). [PMID:31154588]
3. Suzuki H & Yamamoto T. (2014) Amylin-like immunoreactivity in pancreatic X cells of the black-spotted frog Rana (Pelophylax) nigromaculata.. Tissue Cell, 46 (6): (535-9). [PMID:25458814]
4. Cooper GJ, Willis AC, Clark A, Turner RC, Sim RB, Reid KB. (1987) Purification and characterization of a peptide from amyloid-rich pancreases of type 2 diabetic patients.. Proc Natl Acad Sci USA, 84 (23): (8628-32). [PMID:3317417]
5. Jaikaran ET, Clark A. (2001) Islet amyloid and type 2 diabetes: from molecular misfolding to islet pathophysiology.. Biochim Biophys Acta, 1537 (3): (179-203). [PMID:11731221]
6. Ravi Prakash Reddy Nanga,Jeffrey R Brender,Jiadi Xu,Gianluigi Veglia,Ayyalusamy Ramamoorthy. (2008-11-08) Structures of rat and human islet amyloid polypeptide IAPP(1-19) in micelles by NMR spectroscopy.. Biochemistry, 47 ((48)): (12689-12697). [PMID:18989932]
7. Allam S Reddy,Lu Wang,Sadanand Singh,Yun L Ling,Lauren Buchanan,Martin T Zanni,James L Skinner,Juan J de Pablo. (2010-10-07) Stable and metastable states of human amylin in solution.. Biophysical journal, 99 ((7)): (2208-2216). [PMID:20923655]
8. A Clark,M R Nilsson. (2004-01-15) Islet amyloid: a complication of islet dysfunction or an aetiological factor in Type 2 diabetes?. Diabetologia, 47 ((2)): (157-169). [PMID:14722650]
9. Ravi Prakash Reddy Nanga,Jeffrey R Brender,Subramanian Vivekanandan,Ayyalusamy Ramamoorthy. (2011-07-05) Structure and membrane orientation of IAPP in its natively amidated form at physiological pH in a membrane environment.. Biochimica et biophysica acta, 1808 ((10)): (2337-2342). [PMID:21723249]

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糖尿病相关肽(胰岛淀粉样肽)

库存信息

库存信息

基本描述

名称和标识符

数据库链接

安全信息

靶标

关联配体

参考文献

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糖尿病相关肽(胰岛淀粉样肽)

库存信息

库存信息

基本描述

名称和标识符

数据库链接

安全信息

靶标

关联配体

参考文献

相关文档

质检报告COA

产品问答

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