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Zimberelimab (anti-PD-1)

规格或纯度: Purity>95% (SDS-PAGE&SEC); Endotoxin Level<1.0EU/mg; Human IgG4SP; CHO; ELISA, FACS, Functional assay, Animal Model; Unconjugated

种属反应性: Cynomolgus,Human
亚型: Human IgG4SP

有货

库存信息

关闭

库存信息

关闭

库存信息

关闭

货号 (SKU)	包装规格	是否现货
Ab175710-1mg	1mg	期货
Ab175710-5mg	5mg	期货
Ab175710-10mg	10mg	期货

查看相关系列

programmed cell death 1 (CD279) Antibody

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基本信息

产品名称	Zimberelimab (anti-PD-1)
规格或纯度	Purity>95% (SDS-PAGE&SEC); Endotoxin Level<1.0EU/mg; Human IgG4SP; CHO; ELISA, FACS, Functional assay, Animal Model; Unconjugated
特异性	PDCD1
反应种属	Cynomolgus,Human

产品属性

Format	Whole IgG
亚型	Human IgG4SP
轻链亚型	Lambda
SDS-PAGE	146.54 kDa
纯化方法	Protein A purified
物理外观	Liquid
防腐剂	No
浓度	Lot by Lot
储存温度	-80℃储存,避免反复冻融
运输条件	超低温冰袋运输
稳定性与储存	Store at -80℃ for 18 months.?Upon delivery aliquot. Avoid freeze/thaw cycle.
CAS编号和信息	2259860-24-5

数据库链接

IMGT/mAb-DB	1071

靶标

Target ID

2760

名称

programmed cell death 1 (CD279)

缩写名

PD-1

家族

Other immune checkpoint proteins

别名

KCa2.1

基因和蛋白信息

Species	Transmembrane Domains	Amino Acids	Chromosomal Location	Gene Symbol	Gene Name
Human	1	288	2q37.3	PDCD1	programmed cell death 1
Mouse	1	288	1 D	Pdcd1	programmed cell death 1
Rat	1	287	9q36	Pdcd1	programmed cell death 1

OMIM

600244 (Hs)

UniProtKB

Q15116 (Hs) , Q02242 (Mm)

Ensembl Gene

ENSG00000188389 (Hs) , ENSMUSG00000026285 (Mm) , ENSRNOG00000019043 (Rn)

RefSeq Nucleotide

NM_005018 (Hs) , NM_001106927 (Rn) , NM_008798 (Mm)

RefSeq Protein

NP_005009 (Hs) , NP_001100397 (Rn) , NP_032824 (Mm)

Entrez Gene

5133 (Hs) , 301626 (Rn) , 18566 (Mm)

Protein GI

167857792 (Hs) , 6679239 (Mm) , 157817590 (Rn)

CATH/Gene3D

2.60.40.10 (N/A)

ChEMBL Target

CHEMBL3307223 (Hs) , CHEMBL4630756 (Mm)

关联配体

Ligand ID	12349
名称	zimberelimab
别名	AB-122
类别	Antibody
学名	4-amino-N-(4,6-dimethylpyrimidin-2-yl)benzenesulfonamide
生物活性评价	The sulfonamide class of antibacterial compounds are primarily bacteriostatic agents and have a broad spectrum of activity against both Gram-positive and Gram-negative species of bacteria (reviewed in ).
评价	Zimberelimab (AB-122, GLS-010) a fully human, IgG4λ anti-programmed cell death protein-1 (PD-1) monoclonal antibody . It is an immune checkpoint inhibitor class immuno-oncology therapeutic.
配体家族	Immune checkpoint modulators
单字母多肽序列
三字母多肽序列
翻译后修饰
化学修饰

参考文献

1. Lou B, Wei H, Yang F, Wang S, Yang B, Zheng Y, Zhu J, Yan S. (2021) Preclinical Characterization of GLS-010 (Zimberelimab), a Novel Fully Human Anti-PD-1 Therapeutic Monoclonal Antibody for Cancer.. Front Oncol, 11 (13): (736955). [PMID:34604074]
2. Markham A. (2021) Zimberelimab: First Approval.. Drugs, 81 (17): (2063-2068). [PMID:34709602]