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药物靶标
其它蛋白靶标
CD分子
Mezagitamab (anti-CD38)

Mezagitamab (anti-CD38)

功能和特点

规格或纯度: Purity>95% (SDS-PAGE&SEC); Endotoxin Level<1.0EU/mg; Human IgG1; CHO; ELISA, FACS, Functional assay, Animal Model; Unconjugated
反应种属: Cynomolgus,Human,Mouse?,Rhesus Macaque
亚型: Human IgG1

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库存信息

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库存信息

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库存信息

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库存信息

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货号 (SKU)	包装规格	是否现货
Ab175597-100μg (试用装) 申请此免费试用装（?）作为尊贵的客户，您每年可免费申请三次您选择的不同货号试用装产品，尽享探索与享受！	100μg	期货
Ab175597-1mg	1mg	期货
Ab175597-5mg	5mg	期货
Ab175597-10mg	10mg	期货

查看相关系列

Accession#:P28907 CD38 CD38 Antibody Gene ID:952

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基本信息

产品名称	Mezagitamab (anti-CD38)
规格或纯度	Purity>95% (SDS-PAGE&SEC); Endotoxin Level<1.0EU/mg; Human IgG1; CHO; ELISA, FACS, Functional assay, Animal Model; Unconjugated
特异性	CD38
反应种属	Cynomolgus,Human,Mouse?,Rhesus Macaque
偶联标记	Unconjugated

产品属性

克隆	Recombinant
Format	Whole IgG
亚型	Human IgG1
轻链亚型	Lambda
SDS-PAGE	28.1 kDa (Light Chain) & 51.6 kDa (Heavy Chain), under reducing conditions; 182.1 kDa, under non-reducing conditions.
纯化方法	Protein A purified
纯度	>95%
物理外观	Liquid
储存缓冲液	Supplied as a 0.22μm filtered solution in 100mM Pro-Ac, 20mM Arg, pH 5.0
防腐剂	No
浓度	Lot by Lot
储存温度	-80℃储存,避免反复冻融
运输条件	超低温冰袋运输
稳定性与储存	Store at -80℃ for 24 months. Upon delivery aliquot. Avoid freeze/thaw cycle.
CAS编号和信息	2227490-52-8

数据库链接

IMGT/mAb-DB	882

关联配体

Ligand ID	10609
名称	mezagitamab
别名	TAK079
类别	Antibody
学名	4-amino-N-(4,6-dimethylpyrimidin-2-yl)benzenesulfonamide
生物活性评价	TAK‐079 depletes CD38 cells by inducing antibody‐dependent cell‐mediated cytotoxicity and complement‐dependent cytotoxicity . Although extensive pharmacokinetic and pharmacodynamic data for TAK-079 has been published , we have been unable to locate a binding affinity value for the antibody-target interaction. TAK-079 is likely to be one of the antibodies claimed in Takeda patent WO2012092612A1 (potentially that referred to as Ab79 therein), and we have included the binding affinity for the Ab79 construct in the interactions table .
评价	Mezagitamab (TAK-079) is a humanized, IgG1, cell-depleting anti-CD38 monoclonal antibody . Anti-CD38 therapeutics were primarily developed as treatments for multiple myeloma , but have subsequently been discovered to offer potential in solid tumours and autoimmune diseases .
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图片

Flow Cytometry: Mezagitamab (anti-CD38) (Ab175597)

Mezagitamab (anti-CD38) (Ab175597) - Flow Cytometry
Flow Cytometry analysis of human peripheral blood lymphocytes labelling DPP4 with Mezagitamab (anti-CD38) (Ab175597) conjugated with biotin (right panel) compared with Human IgG (Ab170213) conjugated with biotin - Isotype Control (left panel) and detected with SA-PE (rp156250).

Flow Cytometry: Mezagitamab (anti-CD38) (Ab175597)

Mezagitamab (anti-CD38) (Ab175597) - Flow Cytometry
Flow Cytometry analysis of human peripheral blood lymphocytes labelling DPP4 (red) with Mezagitamab (anti-CD38) (Ab175597) conjugated with biotin and detected with SA-PE (rp156250). Blue - Isotype control, human IgG (Ab170213) conjugated with biotin. Black - Unlabelled control, cells without incubation with primary antibody.

Flow Cytometry: Mezagitamab (anti-CD38) (Ab175597)

Mezagitamab (anti-CD38) (Ab175597) - Flow Cytometry
Flow Cytometry analysis of Raji cells labelling CD38 (red) with Mezagitamab (anti-CD38) (Ab175597). Goat Anti-Human IgG (PE) (Ab175838) at a dilution of 1/1000 was used as the secondary antibody. Blue - Isotype control, human IgG (Ab170213). Black - Unlabelled control, cells without incubation with primary antibody.

SEC: Mezagitamab (anti-CD38) (Ab175597)

Mezagitamab (anti-CD38) (Ab175597) - SEC
The purity of Mezagitamab (anti-CD38) (Ab175597) is more than 95% verified by HPLC.

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参考文献

1. Roepcke S, Plock N, Yuan J, Fedyk ER, Lahu G, Zhao L, Smithson G. (2018) Pharmacokinetics and pharmacodynamics of the cytolytic anti-CD38 human monoclonal antibody TAK-079 in monkey - model assisted preparation for the first in human trial.. Pharmacol Res Perspect, 6 (3): (e00402). [PMID:29864242]
2. van de Donk NWCJ, Usmani SZ. (2018) CD38 Antibodies in Multiple Myeloma: Mechanisms of Action and Modes of Resistance.. Front Immunol, 9 (13): (2134). [PMID:30294326]
3. Korver W, Carsillo M, Yuan J, Idamakanti N, Wagoner M, Shi P, Xia CQ, Smithson G, McLean L, Zalevsky J et al.. (2019) A Reduction in B, T, and Natural Killer Cells Expressing CD38 by TAK-079 Inhibits the Induction and Progression of Collagen-Induced Arthritis in Cynomolgus Monkeys.. J Pharmacol Exp Ther, 370 (2): (182-196). [PMID:31085699]