产品名称 | lintuzumab |
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CAS编号和信息 | Ab175581 |
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IMGT/mAb-DB | 53 |
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Wikipedia | Lintuzumab |
Target ID | 2601 | ||||||||||||||||||||||||
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名称 | CD33 | ||||||||||||||||||||||||
缩写名 | SIGLEC3 | ||||||||||||||||||||||||
家族 | Other immune checkpoint proteins | ||||||||||||||||||||||||
别名 | KCa2.1 | ||||||||||||||||||||||||
基因和蛋白信息 |
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Entrez Gene | 945 (Hs) , 12489 (Mm) , 690492 (Rn) | ||||||||||||||||||||||||
UniProtKB | P20138 (Hs) , Q63994 (Mm) | ||||||||||||||||||||||||
Ensembl Gene | ENSG00000105383 (Hs) , ENSMUSG00000004609 (Mm) , ENSRNOG00000037331 (Rn) | ||||||||||||||||||||||||
RefSeq Nucleotide | NM_001111058 (Mm) , NM_001772 (Hs) | ||||||||||||||||||||||||
RefSeq Protein | NP_001104528 (Mm) , NP_001763 (Hs) | ||||||||||||||||||||||||
OMIM | 159590 (Hs) | ||||||||||||||||||||||||
Protein GI | 130979981 (Hs) , 161484603 (Mm) | ||||||||||||||||||||||||
DrugBank Target | P20138 (Hs) | ||||||||||||||||||||||||
CATH/Gene3D | 2.60.40.10 (N/A) | ||||||||||||||||||||||||
ChEMBL Target | CHEMBL1842 (Hs) |
Ligand ID | 7983 |
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名称 | lintuzumab |
别名 | SGN-33 |
类别 | Antibody |
学名 | 4-amino-N-(4,6-dimethylpyrimidin-2-yl)benzenesulfonamide |
生物活性评价 |
The sulfonamide class of antibacterial compounds are primarily bacteriostatic agents and have a broad spectrum of activity against both Gram-positive and Gram-negative species of bacteria (reviewed in |
评价 |
Lintuzumab is a monoclonal antibody directed against CD33, a surface antigen found on myeloid leukemia cells. A modified version of lintuzumab that is conjugated with the chelator satetraxetan to facilitate actinium (225Ac) radiolabelling (a radioimmunotherapeutic) has been developed (see Patent US6670456 |
配体家族 | Immune checkpoint modulators |
单字母多肽序列 | |
三字母多肽序列 | |
翻译后修饰 | |
化学修饰 |
1. Taylor VC, Buckley CD, Douglas M, Cody AJ, Simmons DL, Freeman SD. (1999) The myeloid-specific sialic acid-binding receptor, CD33, associates with the protein-tyrosine phosphatases, SHP-1 and SHP-2.. J Biol Chem, 274 (17): (11505-12). [PMID:10206955] |
2. Ulyanova T, Blasioli J, Woodford-Thomas TA, Thomas ML. (1999) The sialoadhesin CD33 is a myeloid-specific inhibitory receptor.. Eur J Immunol, 29 (11): (3440-9). [PMID:10556798] |
3. Ferlazzo G, Spaggiari GM, Semino C, Melioli G, Moretta L. (2000) Engagement of CD33 surface molecules prevents the generation of dendritic cells from both monocytes and CD34+ myeloid precursors.. Eur J Immunol, 30 (3): (827-33). [PMID:10741398] |
4. Paul SP, Taylor LS, Stansbury EK, McVicar DW. (2000) Myeloid specific human CD33 is an inhibitory receptor with differential ITIM function in recruiting the phosphatases SHP-1 and SHP-2.. Blood, 96 (2): (483-90). [PMID:10887109] |
5. Caron PC, Co MS, Bull MK, Avdalovic NM, Queen C, Scheinberg DA. (1992) Biological and immunological features of humanized M195 (anti-CD33) monoclonal antibodies.. Cancer Res, 52 (24): (6761-7). [PMID:1458463] |
6. Garnache-Ottou F, Chaperot L, Biichle S, Ferrand C, Remy-Martin JP, Deconinck E, de Tailly PD, Bulabois B, Poulet J, Kuhlein E et al.. (2005) Expression of the myeloid-associated marker CD33 is not an exclusive factor for leukemic plasmacytoid dendritic cells.. Blood, 105 (3): (1256-64). [PMID:15388576] |