91高清自产国产拍,无码免费A级毛片大全,日本欧美国产中文字幕,99re热视频这里只有精品视频首页

400-620-6333

提交您使用阿拉丁产品的研究文章，就得100元奖励！立即访问我们的提交页面.

语言

切换导航

我的购物车

搜索

语言

Imaprelimab (anti-CD146)

功能和特点

规格或纯度: Purity>95% (SDS-PAGE&SEC); Endotoxin Level<1.0EU/mg; Human IgG1; CHO; ELISA, FACS, Functional assay, Animal Model; Unconjugated
反应种属: Cynomolgus,Human,Mouse?
亚型: Human IgG1

有货

库存信息

关闭

库存信息

关闭

库存信息

关闭

库存信息

关闭

货号 (SKU)	包装规格	是否现货	价格	数量
Ab175560-100μg (试用装) 申请此免费试用装（?）作为尊贵的客户，您每年可免费申请三次您选择的不同货号试用装产品，尽享探索与享受！	100μg	期货
Ab175560-1mg	1mg	现货
Ab175560-5mg	5mg	现货
Ab175560-10mg	10mg	期货

查看相关系列

Accession#:P43121 CD146 Gene ID:4162 MCAM melanoma cell adhesion molecule Antibody

Skip to the end of the images gallery

main product photo

Skip to the beginning of the images gallery

基本信息

产品名称	Imaprelimab (anti-CD146)
规格或纯度	Purity>95% (SDS-PAGE&SEC); Endotoxin Level<1.0EU/mg; Human IgG1; CHO; ELISA, FACS, Functional assay, Animal Model; Unconjugated
特异性	MCAM
反应种属	Cynomolgus,Human,Mouse?
偶联标记	Unconjugated

产品属性

克隆	Recombinant
Format	Whole IgG
亚型	Human IgG1
轻链亚型	Kappa
SDS-PAGE	144.74 kDa
纯化方法	Protein A purified
纯度	>95%
物理外观	Liquid
储存缓冲液	Supplied as a 0.22μm filtered solution in 100mM Pro-Ac, 20mM Arg, pH 5.0
防腐剂	No
浓度	Lot by Lot
储存温度	-80℃储存,避免反复冻融
运输条件	超低温冰袋运输
稳定性与储存	Store at -80℃ for 24 months. Upon delivery aliquot. Avoid freeze/thaw cycle.
CAS编号和信息	2014343-04-3

数据库链接

IMGT/mAb-DB	808

关联配体

Ligand ID	9805
名称	imaprelimab
别名	PRX003
类别	Antibody
学名	4-amino-N-(4,6-dimethylpyrimidin-2-yl)benzenesulfonamide
生物活性评价	The affinity constant for antibody h2120VH5/L3 binding to human MCAM provided in WO2014039975 appears to be quoted in μg/ml. Based on an average molecular weight of ~150kDa for an antibody the Kd of 1.3 μg/ml provided, converts to ~8.7nM..
评价	Imaprelimab (PRX-003) is an anti-MCAM mAb developed as a novel therapy for psoriasis. In patients with autoimmune diseases, a subset of MCAM+ve T cells (which have an effector memory T-helper 17 phenotype) produce high levels of pro-inflammatory IL-17 . Pharmacological disruption of MCAM function is thought to be a valid mechanism for the treatment of autoimmune inflammation. Peptide sequence alignments identify imaprelimab as one of the preferred antibodies claimed in patent WO2014039975 (SEQ IDs 119 and 123 match the sequences submitted to the WHO for INN imaprelimab). These peptide sequences map to the construct identified as h2120VH5/L3.
单字母多肽序列
三字母多肽序列
翻译后修饰
化学修饰
临床描述	This multiple ascending dose study is to determine safety, tolerability, pharmacokinetics and immunogenicity of PRX003 in approximately 56 patients with Psoriasis.
来源公司	Prothena Biosciences Limited

图片

Flow Cytometry: Imaprelimab (anti-CD146) (Ab175560)

Imaprelimab (anti-CD146) (Ab175560) - Flow Cytometry
Flow Cytometry analysis of HeLa cells labelling CD146 (red) with Imaprelimab (anti-CD146) (Ab175560). Goat Anti-Human IgG (PE) (Ab175838) at a dilution of 1/1000 was used as the secondary antibody. Blue - Isotype control, human IgG (Ab170213). Black - Unlabelled control, cells without incubation with primary antibody.

Flow Cytometry: Imaprelimab (anti-CD146) (Ab175560)

Imaprelimab (anti-CD146) (Ab175560) - Flow Cytometry
Flow Cytometry analysis of A375 cells labelling CD146 (red) with Imaprelimab (anti-CD146) (Ab175560). Goat Anti-Human IgG (PE) (Ab175838) at a dilution of 1/1000 was used as the secondary antibody. Blue - Isotype control, human IgG (Ab170213). Black - Unlabelled control, cells without incubation with primary antibody.

SEC: Imaprelimab (anti-CD146) (Ab175560)

Imaprelimab (anti-CD146) (Ab175560) - SEC
The purity of Imaprelimab (anti-CD146) (Ab175560) is more than 95% verified by HPLC.

相关文档

质检报告COA

请输入批号:

SDS中文版 SDS英文版

质量技术规格说明书

产品问答

产品问答

登录提交问题

您提交该产品问题后,我们会在1-2个工作日内给您答复,您可以登录"我的账号",然后点击"我的产品问答"查看答案

参考文献

1. Wu C, Goodall JC, Busch R, Gaston JS. (2015) Relationship of CD146 expression to secretion of interleukin (IL)-17, IL-22 and interferon-γ by CD4(+) T cells in patients with inflammatory arthritis.. Clin Exp Immunol, 179 (3): (378-91). [PMID:25113810]
2. Dagur PK, McCoy Jr JP. (2015) Endothelial-binding, proinflammatory T cells identified by MCAM (CD146) expression: Characterization and role in human autoimmune diseases.. Autoimmun Rev, 14 (5): (415-22). [PMID:25595133]

上海阿拉丁生化科技股份有限公司

销售条款及条件 ? ? ? ? 隐私政策

? 2016 ALADDIN-E.COM . 版权所有,未经授权禁止拷贝本站资料,如有违反,将追究法律责任

沪公网安备 31012002004058号沪ICP备09093490号-2

本网站销售的所有产品仅用于工业应用或者科学研究等非医疗目的,不可用于人类或动物的临床诊断或者治疗,非药用,非食用。

危险品化学品经营许可证（带存储）

营业执照(三证合一)