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Enoblituzumab (anti-CD276)

功能和特点
  • 规格或纯度: Purity>95% (SDS-PAGE&SEC); Endotoxin Level<1.0EU/mg; Human IgG1; CHO; ELISA, FACS, Functional assay, Animal Model; Unconjugated
  • 反应种属: Cynomolgus,Human
  • 亚型: Human IgG1
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库存信息

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库存信息

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库存信息

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库存信息

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货号 (SKU) 包装规格 是否现货 价格 数量
Ab175529-100μg (试用装)
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 		100μg 期货 Stock Image
Ab175529-1mg
 1mg 现货 Stock Image
Ab175529-5mg
 5mg 现货 Stock Image
Ab175529-10mg
 10mg 期货 Stock Image
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Accession#:Q5ZPR3 B7-H3 (CD276) Antibody CD276 Gene ID:80381
main product photo

基本信息

产品名称 Enoblituzumab (anti-CD276)
规格或纯度 Purity>95% (SDS-PAGE&SEC); Endotoxin Level<1.0EU/mg; Human IgG1; CHO; ELISA, FACS, Functional assay, Animal Model; Unconjugated
特异性 CD276
反应种属 Cynomolgus,Human
偶联标记 Unconjugated

产品属性

克隆 Recombinant
Format Whole IgG
亚型 Human IgG1
轻链亚型 Kappa
SDS-PAGE 26.7 kDa (Light Chain) & 51.2 kDa (Heavy Chain), under reducing conditions; 182.0 kDa, under non-reducing conditions.
纯化方法 Protein A purified
纯度 >95%
物理外观 Liquid
储存缓冲液 Supplied as a 0.22μm filtered solution in 100mM Pro-Ac, 20mM Arg, pH 5.0
防腐剂 No
浓度 Lot by Lot
储存温度 -80℃储存,避免反复冻融
运输条件 超低温冰袋运输
稳定性与储存 Store at -80℃ for 24 months. Upon delivery aliquot. Avoid freeze/thaw cycle.
CAS编号和信息 1353485-38-7

关联配体

Ligand ID 9589
名称 enoblituzumab
别名 MGA271
类别 Antibody
学名 4-amino-N-(4,6-dimethylpyrimidin-2-yl)benzenesulfonamide
生物活性评价 Enoblituzumab has potent antitumour activity in B7-H3-expressing cancers, which is mediated by potent ADCC .
评价 Enoblituzumab (MGA271) is a humanized IgG1κ mAb with enhanced ADCC. Its target is the B7-H3 (CD276) member of the B7 family of immune regulators . It has been engineered to enhance effector-mediated antitumor function via increased affinity for the activating receptor CD16A (FcγRIII) and decreased binding to the inhibitory receptor CD32B (FcγRIIB).
Annotated peptide sequences for this antibody are available from its IMGT/mAb-DB record.
BLAST sequence analysis identifies exact matches with antibody peptides claimed in patent US8802091, and specifically with a construct designated as hBRCA84D-2 .
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图片

Enoblituzumab (anti-CD276) (Ab175529) - Flow Cytometry
Flow Cytometry analysis of MCF-7 cells labelling CD276 (red) with Enoblituzumab (anti-CD276) (Ab175529). Goat Anti-Human IgG (PE) (Ab175838) at a dilution of 1/1000 was used as the secondary antibody. Blue - Isotype control, human IgG (Ab170213). Black - Unlabelled control, cells without incubation with primary antibody.

Enoblituzumab (anti-CD276) (Ab175529) - Flow Cytometry
Flow Cytometry analysis of HEK-293 cells labelling CD276 (red) with Enoblituzumab (anti-CD276) (Ab175529). Goat Anti-Human IgG (PE) (Ab175838) at a dilution of 1/1000 was used as the secondary antibody. Blue - Isotype control, human IgG (Ab170213). Black - Unlabelled control, cells without incubation with primary antibody.

Enoblituzumab (anti-CD276) (Ab175529) - SEC
The purity of Enoblituzumab (anti-CD276) (Ab175529) is more than 95% verified by HPLC.

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参考文献

1. Loo D, Alderson RF, Chen FZ, Huang L, Zhang W, Gorlatov S, Burke S, Ciccarone V, Li H, Yang Y et al..  (2012)  Development of an Fc-enhanced anti-B7-H3 monoclonal antibody with potent antitumor activity..  Clin Cancer Res,  18  (14):  (3834-45).  [PMID:22615450]
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