| 货号 (SKU) | 包装规格 | 是否现货 | 价格 | 数量 |
|---|---|---|---|---|
| Ab169321-1mg | 1mg |
现货  |
| |
| Ab169321-5mg | 5mg |
现货 |
| |
| Ab169321-10mg | 10mg |
期货 |
|
| 产品名称 | Relatlimab (anti-LAG-3/CD223) |
|---|---|
| 规格或纯度 | Purity>95% (SDS-PAGE&SEC); Endotoxin Level<1.0EU/mg; Human IgG4SP; CHO; ELISA, FACS, Functional assay, Animal Model; Unconjugated |
| 特异性 | LAG3/CD223 |
| 应用 | Flow,ELISA,Functional Assay,Kinetics (BLI),Kinetics (SPR) |
| 反应种属 | Cynomolgus,Human |
| 偶联标记 | Unconjugated |
| 抗体类型 | Primary antibody |
|---|---|
| 克隆 | Recombinant |
| Format | Whole IgG |
| 亚型 | Human IgG4SP |
| 轻链亚型 | Kappa |
| SDS-PAGE | 27.1 kDa (Light Chain) & 53.4 kDa (Heavy Chain), under reducing conditions; 176.6 kDa, under non-reducing conditions. |
| 纯化方法 | Protein A purified |
| 来源 | CHO supernatant |
| 物理外观 | Liquid |
| 储存缓冲液 | Supplied as a 0.22 μm filtered solution in 100mM Pro-Ac, 20mM Arg, pH 5.0 |
| 防腐剂 | No |
| 浓度 | Lot by Lot |
| 储存温度 | -80℃储存,避免反复冻融 |
| 运输条件 | 超低温冰袋运输 |
| 稳定性与储存 | Store at -80℃ for 18 months. Upon delivery aliquot. Avoid freeze/thaw cycle. |
| CAS编号和信息 | 1673516-98-7 |
| IMGT/mAb-DB | 781 |
|---|
| Target ID | 2932 | ||||||||||||||||||||||||
|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|
| 名称 | LAG3 (CD223) | ||||||||||||||||||||||||
| 缩写名 | SHP2 | ||||||||||||||||||||||||
| 家族 | Other immune checkpoint proteins | ||||||||||||||||||||||||
| 别名 | KCa2.1 | ||||||||||||||||||||||||
| 基因和蛋白信息 |
|
||||||||||||||||||||||||
| UniProtKB | P18627 (Hs) , Q61790 (Mm) | ||||||||||||||||||||||||
| RefSeq Protein | NP_002277 (Hs) , NP_032505 (Mm) , NP_997678 (Rn) | ||||||||||||||||||||||||
| RefSeq Nucleotide | NM_002286 (Hs) , NM_008479 (Mm) , NM_212513 (Rn) | ||||||||||||||||||||||||
| Ensembl Gene | ENSG00000089692 (Hs) , ENSMUSG00000030124 (Mm) , ENSRNOG00000021334 (Rn) | ||||||||||||||||||||||||
| OMIM | 153337 (Hs) | ||||||||||||||||||||||||
| Entrez Gene | 3902 (Hs) , 16768 (Mm) , 297596 (Rn) | ||||||||||||||||||||||||
| CATH/Gene3D | 2.60.40.10 (N/A) | ||||||||||||||||||||||||
| Protein GI | 251757512 (Hs) , 2497295 (Mm) | ||||||||||||||||||||||||
| ChEMBL Target | CHEMBL4630881 (Hs) |
| Ligand ID | 9536 |
|---|---|
| 名称 | relatlimab |
| 别名 | ONO-4482 |
| 类别 | Antibody |
| 学名 | 4-amino-N-(4,6-dimethylpyrimidin-2-yl)benzenesulfonamide |
| 生物活性评价 |
The sulfonamide class of antibacterial compounds are primarily bacteriostatic agents and have a broad spectrum of activity against both Gram-positive and Gram-negative species of bacteria (reviewed in |
| 评价 | Relatlimab (BMS-986016) is an anti-LAG3 monoclonal antibody that was developed for utility in cancer immunotherapy. |
| 配体家族 | Immune checkpoint modulators |
| 单字母多肽序列 | |
| 三字母多肽序列 | |
| 翻译后修饰 | |
| 化学修饰 | |
| 临床描述 |
The purpose of this study is to determine whether nivolumab in combination with relatlimab is
more effective than nivolumab by itself in treating unresectable melanoma or melanoma that
has spread
|
| 来源公司 |
Bristol-Myers Squibb |
| 1. Huang CT, Workman CJ, Flies D, Pan X, Marson AL, Zhou G, Hipkiss EL, Ravi S, Kowalski J, Levitsky HI et al.. (2004) Role of LAG-3 in regulatory T cells.. Immunity, 21 (4): (503-13). [PMID:15485628] |
| 2. Nguyen LT, Ohashi PS. (2015) Clinical blockade of PD1 and LAG3--potential mechanisms of action.. Nat Rev Immunol, 15 (1): (45-56). [PMID:25534622] |
Relatlimab (anti-LAG-3/CD223) (Ab169321) - Flow Cytometry
Flow Cytometry analysis of PHA-stimulated (3 days) human peripheral blood mononuclear lymphocytes labelling LAG-3/CD223 (red) with Relatlimab (anti- LAG-3/CD223) (Ab169321). Goat Anti-Human IgG (PE) (Ab175838) at a dilution of 1/1000 was used as the secondary antibody. Blue - Isotype control, human IgG (Ab170213). Black - Unlabelled control, cells without incubation with primary antibody.
Relatlimab (anti-LAG-3/CD223) (Ab169321) - SEC
The purity of Relatlimab (anti-LAG-3/CD223) (Ab169321) is more than 95% verified by HPLC.
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