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Spartalizumab (anti-PD-1)

功能和特点

规格或纯度: Purity>95% (SDS-PAGE&SEC); Endotoxin Level<1.0EU/mg; Human IgG4SP; CHO; ELISA, FACS, Functional assay, Animal Model; Unconjugated
应用: ELISA,Functional Assay,Kinetics (BLI),Kinetics (SPR),Flow Cyt
反应种属: Cynomolgus,Human
亚型: Human IgG4SP

有货

库存信息

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库存信息

关闭

库存信息

关闭

库存信息

关闭

货号 (SKU)	包装规格	是否现货	价格	数量
Ab169299-100μg (试用装) 申请此免费试用装（?）作为尊贵的客户，您每年可免费申请三次您选择的不同货号试用装产品，尽享探索与享受！	100μg	期货
Ab169299-1mg	1mg	现货
Ab169299-5mg	5mg	现货
Ab169299-10mg	10mg	期货

查看相关系列

Accession#:Q15116 Gene ID:5133 PD1 PDCD1 programmed cell death 1 (CD279) Antibody

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基本信息

产品名称	Spartalizumab (anti-PD-1)
规格或纯度	Purity>95% (SDS-PAGE&SEC); Endotoxin Level<1.0EU/mg; Human IgG4SP; CHO; ELISA, FACS, Functional assay, Animal Model; Unconjugated
特异性	PDCD1
应用	ELISA,Functional Assay,Kinetics (BLI),Kinetics (SPR),Flow Cyt
反应种属	Cynomolgus,Human
偶联标记	Unconjugated

产品属性

抗体类型	Primary antibody
克隆	Recombinant
Format	Whole IgG
亚型	Human IgG4SP
轻链亚型	Kappa
SDS-PAGE	28.1 kDa (Light Chain) & 51.7 kDa (Heavy Chain), under reducing conditions; 175.9 kDa, under non-reducing conditions.
纯化方法	Protein A purified
纯度	>95%
来源	CHO supernatant
物理外观	Liquid
储存缓冲液	Supplied as a 0.22 μm filtered solution in 100mM Pro-Ac, 20mM Arg, pH 5.0
防腐剂	No
浓度	Lot by Lot
储存温度	-80℃储存,避免反复冻融
运输条件	超低温冰袋运输
稳定性与储存	Store at -80℃ for 24 months. Upon delivery aliquot. Avoid freeze/thaw cycle.
CAS编号和信息	1935694-88-4

数据库链接

IMGT/mAb-DB	761

关联配体

Ligand ID	10140
名称	spartalizumab
别名	PDR001
类别	Antibody
学名	4-amino-N-(4,6-dimethylpyrimidin-2-yl)benzenesulfonamide
生物活性评价	The sulfonamide class of antibacterial compounds are primarily bacteriostatic agents and have a broad spectrum of activity against both Gram-positive and Gram-negative species of bacteria (reviewed in ).
评价	Spartalizumab (PDR001) is a humanized, IgG4κ anti-PD-1 monoclonal antibody immuno-oncology lead that is being developed by Novartis. Sequence and structural information about this antibody are available from its IMGT/mAb-DB entry. BLAST analysis of the peptide sequences submitted to the WHO for the INN spartalizumab reveal exact matches with peptide sequences claimed in patent US9683048B2 , specifically SEQ ID NO: 91 for the entire heavy chain and SEQ ID NO: 72 for the entire light chain. Sequence IDs 91 and 72 are components of the antibody designated as BAP049-Clone-E which is one of the humanized clones generated in the discovery campaign described in US9683048B2.
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ELISA: Spartalizumab (anti-PD-1) (Ab169299)

Spartalizumab (anti-PD-1) (Ab169299) - ELISA
Immobilized Recombinant Human PD-1 Protein at 1 μg/mL can bind Spartalizumab (anti-PD-1) (Ab169299) with the EC?? of 39.7 ng/mL.

SEC: Spartalizumab (anti-PD-1) (Ab169299)

Spartalizumab (anti-PD-1) (Ab169299) - SEC
The purity of Spartalizumab (anti-PD-1) (Ab169299) is more than 95% verified by HPLC.

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