| 货号 (SKU) | 包装规格 | 是否现货 | 价格 | 数量 |
|---|---|---|---|---|
|
Ab169280-100μg (试用装) 申请此免费试用装（?） 作为尊贵的客户，您每年可免费申请三次您选择的不同货号试用装产品，尽享探索与享受！
|
100μg |
期货  |
| |
|
Ab169280-1mg |
1mg |
现货 |
| |
|
Ab169280-5mg |
5mg |
现货 |
| |
|
Ab169280-10mg |
10mg |
期货 |
|
| 产品名称 | Isatuximab (anti-CD38) |
|---|---|
| 规格或纯度 | Purity>95% (SDS-PAGE&SEC); Endotoxin Level<1.0EU/mg; Human IgG1; CHO; ELISA, FACS, Functional assay, Animal Model; Unconjugated |
| 特异性 | CD38 |
| 应用 | ELISA,Functional Assay,Kinetics (BLI),Kinetics (SPR),Flow Cyt |
| 反应种属 | Human |
| 偶联标记 | Unconjugated |
| 抗体类型 | Primary antibody |
|---|---|
| 克隆 | Recombinant |
| Format | Whole IgG |
| 亚型 | Human IgG1 |
| 轻链亚型 | Kappa |
| SDS-PAGE | 26.2 kDa (Light Chain) & 51.1 kDa (Heavy Chain), under reducing conditions; 176.8 kDa, under non-reducing conditions. |
| 纯化方法 | Protein A purified |
| 纯度 | >95% |
| 来源 | CHO supernatant |
| 物理外观 | Liquid |
| 储存缓冲液 | Supplied as a 0.22 μm filtered solution in 100mM Pro-Ac, 20mM Arg, pH 5.0 |
| 防腐剂 | No |
| 浓度 | Lot by Lot |
| 储存温度 | -80℃储存,避免反复冻融 |
| 运输条件 | 超低温冰袋运输 |
| 稳定性与储存 | Store at -80℃ for 24 months. Upon delivery aliquot. Avoid freeze/thaw cycle. |
| CAS编号和信息 | 1461640-62-9 |
| IMGT/mAb-DB | 539 |
|---|
| Ligand ID | 8719 |
|---|---|
| 名称 | isatuximab |
| 别名 | SAR-650984 |
| 类别 | Antibody |
| 学名 | 4-amino-N-(4,6-dimethylpyrimidin-2-yl)benzenesulfonamide |
| 生物活性评价 |
The affinity values in the table below represents the Kds provided in US20110262454 A1 |
| 评价 |
Isatuximab is an anti-CD38 monoclonal antibody that was designed for anti-tumour potential A patent search identifies the peptide sequences of the light and heavy chain variable regions of isatuximab as SEQ ID NO: 22 and SEQ ID NO: 21 from patent US 8877899 B2 |
| 单字母多肽序列 | |
| 三字母多肽序列 | |
| 翻译后修饰 | |
| 化学修饰 |
Isatuximab (anti-CD38) (Ab169280) - Flow Cytometry
Flow Cytometry analysis of Raji cells labelling CD38 (red) with Isatuximab (anti-CD38) (Ab169280). Goat Anti-Human IgG (PE) (Ab175838) at a dilution of 1/1000 was used as the secondary antibody. Blue - Isotype control, human IgG (Ab170213). Black - Unlabelled control, cells without incubation with primary antibody.
Isatuximab (anti-CD38) (Ab169280) - SEC
The purity of Isatuximab (anti-CD38) (Ab169280) is more than 95% verified by HPLC.
| 1. Deckert J, Wetzel MC, Bartle LM, Skaletskaya A, Goldmacher VS, Vallée F, Zhou-Liu Q, Ferrari P, Pouzieux S, Lahoute C et al.. (2014) SAR650984, a novel humanized CD38-targeting antibody, demonstrates potent antitumor activity in models of multiple myeloma and other CD38+ hematologic malignancies.. Clin Cancer Res, 20 (17): (4574-83). [PMID:24987056] |
| 2. Richardson PG, Attal M, Campana F, Le-Guennec S, Hui AM, Risse ML, Corzo K, Anderson KC. (2018) Isatuximab plus pomalidomide/dexamethasone versus pomalidomide/dexamethasone in relapsed/refractory multiple myeloma: ICARIA Phase III study design.. Future Oncol, 14 (11): (1035-1047). [PMID:29268619] |
| 3. Attal M, Richardson PG, Rajkumar SV, San-Miguel J, Beksac M, Spicka I, Leleu X, Schjesvold F, Moreau P, Dimopoulos MA et al.. (2019) Isatuximab plus pomalidomide and low-dose dexamethasone versus pomalidomide and low-dose dexamethasone in patients with relapsed and refractory multiple myeloma (ICARIA-MM): a randomised, multicentre, open-label, phase 3 study.. Lancet, 394 (10214): (2096-2107). [PMID:31735560] |
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