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A947

PubChem编号: 139546336

有货

库存信息

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库存信息

关闭

货号 (SKU)	包装规格	是否现货	价格	数量
A607314-5mg	5mg	期货
A607314-25mg	25mg	期货

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SWI/SNF related，matrix associated，actin dependent regulator of chromatin，subfamily a，member 2 SWI/SNF related，matrix associated，actin dependent regulator of chromatin，subfamily a，member 4

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基本描述

英文名称	A947

名称和标识符

IUPAC Name	(2S,4R)-1-[(2R)-2-[3-[4-[[4-[3-[4-[3-[3-amino-6-(2-hydroxyphenyl)pyridazin-4-yl]-3,8-diazabicyclo[3.2.1]octan-8-yl]pyridin-2-yl]oxycyclobutyl]oxypiperidin-1-yl]methyl]piperidin-1-yl]-1,2-oxazol-5-yl]-3-methylbutanoyl]-4-hydroxy-N-[(1S)-1-[4-(4-methyl-1,3-thiazol-5-yl)phenyl]ethyl]pyrrolidine-2-carboxamide
INCHI	InChI=1S/C61H76N12O7S/c1-36(2)57(61(77)72-34-45(74)26-52(72)60(76)65-37(3)40-9-11-41(12-10-40)58-38(4)64-35-81-58)54-30-55(68-80-54)70-23-16-39(17-24-70)31-69-21-18-46(19-22-69)78-47-27-48(28-47)79-56-25-42(15-20-63-56)73-43-13-14-44(73)33-71(32-43)51-29-50(66-67-59(51)62)49-7-5-6-8-53(49)75/h5-12,15,20,25,29-30,35-37,39,43-48,52,57,74-75H,13-14,16-19,21-24,26-28,31-34H2,1-4H3,(H2,62,67)(H,65,76)/t37-,43?,44?,45+,47?,48?,52-,57+/m0/s1
InChi Key	QQVCUSPUMMUFTD-NCXNEFEISA-N
Canonical SMILES	Cc1c(scn1)c1ccc(cc1)[C@H](C)NC(=O)[C@@H]1C[C@H](CN1C(=O)[C@@H](c1cc(no1)N1CCC(CC1)CN1CCC(CC1)OC1CC(C1)Oc1nccc(c1)N1C2CCC1CN(C2)c1cc(nnc1N)c1ccccc1O)C(C)C)O
PubChem CID	139546336

数据库链接

PubChem CID	139546336

关联配体

Ligand ID	12308
名称	A947
类别	Synthetic organic
学名	(2S,4R)-1-[(2R)-2-[3-[4-[[4-[3-[4-[3-[3-amino-6-(2-hydroxyphenyl)pyridazin-4-yl]-3,8-diazabicyclo[3.2.1]octan-8-yl]pyridin-2-yl]oxycyclobutyl]oxypiperidin-1-yl]methyl]piperidin-1-yl]-1,2-oxazol-5-yl]-3-methylbutanoyl]-4-hydroxy-N-[(1S)-1-[4-(4-methyl-1,3-thiazol-5-yl)phenyl]ethyl]pyrrolidine-2-carboxamide
生物活性评价	The DC₅₀ for A947-mediated SMARCA2 degradation in SW1573 cells is 39 pM, and a maximum protein degradation of 96% is achieved at 10?nM . The DC₅₀ for SMARCA4 is 1.1 nM in the same cells.
评价	A947 is a selective degrader of SMARCA2 . It is a PROTAC class molecule that targets SMARCA2 protein for degradation via ligation with the VHL E3 ubiquitin ligase. Its target protein binding component interacts with the bromodomains of SMARCA2 and -4 and the 5th bromodomain of polybromo 1 (PBRM1). A947 was developed by Arvinas/Genentech to assess the utility of targeting SMARCA2 in SMARCA4-mutated cancers that become dependent on the SMARCA2 paralog for survival.
配体家族	PROTACs, molecular glues and other degraders

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参考文献

1. Cantley J, Ye X, Rousseau E, Januario T, Hamman BD, Rose CM, Cheung TK, Hinkle T, Soto L, Quinn C et al.. (2022) Selective PROTAC-mediated degradation of SMARCA2 is efficacious in SMARCA4 mutant cancers.. Nat Commun, 13 (1): (6814). [PMID:36357397]

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