91高清自产国产拍,无码免费A级毛片大全,日本 欧美 国产中文字幕,99re热视频这里只有精品视频首页

首页   400-620-6333
提交您使用阿拉丁产品的研究文章，就得100元奖励！立即访问我们的提交页面.
语言
Chinese
切换导航
我的购物车
搜索
搜索444
高级搜索
菜单
账号
设置
语言
Chinese

阿托品

强效，竞争性，非选择性mAChR拮抗剂
规格或纯度: 99%
有货

库存信息

关闭

库存信息

关闭

库存信息

关闭
货号 (SKU) 包装规格 是否现货 价格 数量
A135946-250mg 250mg 现货 Stock Image
A135946-1g 1g 现货 Stock Image
A135946-5g 5g 现货 Stock Image
大包装询价 添加到收藏夹 比较
查看相关系列
Glycine Receptor (All subtypes) Antagonist Glycine Receptor (All subtypes) Subunit-specific M1 receptor Antagonist M2 receptor Antagonist M3 receptor Antagonist M4 receptor Antagonist M5 receptor Antagonist α2A-adrenoceptor Antagonist
main product photo

基本描述

规格或纯度 99%
英文名称 Atropine
别名 莨菪碱；阿托品
英文别名 Hyoscyamine;Tropine DL-tropate;DL-Hyoscyamine Tropine tropate; endo-(±)-α-(Hydroxymethyl)benzeneacetic acid 8-methyl-8-azabicyclo[3.2.1]oct-3-yl ester
生化机理 位于中枢和外周毒蕈碱型乙酰胆碱受体处的竞争性非选择性拮抗剂。强效，竞争性，非选择性mAChR拮抗剂（IC 50 = 2.5 nM）。引起瞳孔散大。在体内显示抗毒蕈碱和抗胆碱能作用。口服具有活性
储存温度 2-8°C储存,避光,充氩
运输条件 冰袋运输
备注 如果有可能，您尽量在使用的当天配置溶液，并在当天使用完它。但是，如果您需要预先配制储备溶液，我们建议您将溶液等份保存在-20°C的密封小瓶中。通常，它们最多可以使用一个月。在使用前和打开样品瓶之前，我们建议您让您的产品在室温下平衡至少1小时。有毒，请参阅SDS以获取更多信息。需要更多关于溶解度，用法和处理的建议吗？请访问我们的常见问题（FAQ）页面以获取更多详细信息。
产品介绍

Atropine is a medication used to treat certain types of nerve agent and pesticide poisonings, some types of slow heart rate, and to decrease saliva production during surgery.

名称和标识符

EC号 200-104-8
IUPAC Name [(1R,5S)-8-methyl-8-azabicyclo[3.2.1]octan-3-yl] 3-hydroxy-2-phenylpropanoate
INCHI InChI=1S/C17H23NO3/c1-18-13-7-8-14(18)10-15(9-13)21-17(20)16(11-19)12-5-3-2-4-6-12/h2-6,13-16,19H,7-11H2,1H3/t13-,14+,15?,16?
InChi Key RKUNBYITZUJHSG-PJPHBNEVSA-N
Canonical SMILES CN1C2CCC1CC(C2)OC(=O)C(CO)C3=CC=CC=C3
分子式

C17H23NO3
PubChem CID 174174
Beilstein号 91260
分子量 289.37

化学和物理性质

溶解性 Soluble in dilute aqueous acid, ethanol.
敏感性 对光线和空气敏感

安全信息

象形图
ghs06

Toxic
信号词 Danger
危险声明 H300+H330: Fatal if swallowed or if inhaled
预防措施声明 P301+P310,P310,P264,P260,P284
WGK Germany 3
RTECS CK0700000
个人防护装备 Eyeshields, Faceshields, full-face particle respirator type N100 (US), Gloves, respirator cartridge type N100 (US), type P1 (EN143) respirator filter, type P3 (EN 143) respirator cartridges

靶标

Target ID 13
名称 M1 receptor
缩写名 SHP2
家族 Acetylcholine receptors (muscarinic)
别名 5-HT1Dα
基因和蛋白信息
Species Transmembrane Domains Amino Acids Chromosomal Location Gene Symbol Gene Name
Rat 7 460 1q43 Chrm1 cholinergic receptor, muscarinic 1
Human 7 460 11q12.3 CHRM1 cholinergic receptor muscarinic 1
Mouse 7 460 19 A Chrm1 cholinergic receptor, muscarinic 1, CNS
RefSeq Protein NP_542951 (Rn) , NP_000729 (Hs) , NP_031724 (Mm)
UniProtKB P08482 (Rn) , P11229 (Hs) , P12657 (Mm)
OMIM 118510 (Hs)
RefSeq Nucleotide NM_000738 (Hs) , NM_080773 (Rn) , NM_007698 (Mm)
Entrez Gene 1128 (Hs) , 25229 (Rn) , 12669 (Mm)
Ensembl Gene ENSG00000168539 (Hs) , ENSMUSG00000032773 (Mm) , ENSRNOG00000018385 (Rn)
Protein GI 18249941 (Rn) , 37622910 (Hs) , 162951826 (Mm)
GPCRdb acm1_human (Hs) , acm1_mouse (Mm) , acm1_rat (Rn)
UniProtKB ID/Entry name ACM1_HUMAN (Hs) , ACM1_MOUSE (Mm) , ACM1_RAT (Rn)
DrugBank Target P11229 (Hs)
ChEMBL Target CHEMBL276 (Rn) , CHEMBL216 (Hs) , CHEMBL3733 (Mm)
Target ID 14
名称 M2 receptor
缩写名 SHP2
家族 Acetylcholine receptors (muscarinic)
别名 5-HT1Dα
基因和蛋白信息
Species Transmembrane Domains Amino Acids Chromosomal Location Gene Symbol Gene Name
Rat 7 466 4q22 Chrm2 cholinergic receptor, muscarinic 2
Human 7 466 7q33 CHRM2 cholinergic receptor muscarinic 2
Mouse 7 466 6 B1 Chrm2 cholinergic receptor, muscarinic 2, cardiac
RefSeq Protein NP_112278 (Rn) , NP_000730 (Hs) , NP_987076 (Mm)
UniProtKB P10980 (Rn) , P08172 (Hs) , Q9ERZ4 (Mm)
OMIM 118493 (Hs)
RefSeq Nucleotide NM_000739 (Hs) , NM_031016 (Rn) , NM_203491 (Mm)
Entrez Gene 1129 (Hs) , 81645 (Rn) , 243764 (Mm)
Ensembl Gene ENSG00000181072 (Hs) , ENSMUSG00000045613 (Mm) , ENSRNOG00000046972 (Rn)
Protein GI 13591922 (Rn) , 54792117 (Hs) , 282721106 (Mm)
GPCRdb acm2_human (Hs) , acm2_mouse (Mm) , acm2_rat (Rn)
UniProtKB ID/Entry name ACM2_HUMAN (Hs) , ACM2_MOUSE (Mm) , ACM2_RAT (Rn)
DrugBank Target P08172 (Hs)
ChEMBL Target CHEMBL309 (Rn) , CHEMBL3197 (Mm) , CHEMBL211 (Hs)
Target ID 15
名称 M3 receptor
缩写名 SHP2
家族 Acetylcholine receptors (muscarinic)
别名 5-HT1Dα
基因和蛋白信息
Species Transmembrane Domains Amino Acids Chromosomal Location Gene Symbol Gene Name
Rat 7 589 17q12.1 Chrm3 cholinergic receptor, muscarinic 3
Human 7 590 1q43 CHRM3 cholinergic receptor muscarinic 3
Mouse 7 589 13 3.72 cM Chrm3 cholinergic receptor, muscarinic 3, cardiac
RefSeq Protein NP_036659 (Rn) , NP_000731 (Hs) , NP_150372 (Mm)
UniProtKB P08483 (Rn) , P20309 (Hs) , Q9ERZ3 (Mm)
OMIM 118494 (Hs)
RefSeq Nucleotide NM_000740 (Hs) , NM_012527 (Rn) , NM_033269 (Mm)
Entrez Gene 1131 (Hs) , 24260 (Rn) , 12671 (Mm)
Ensembl Gene ENSG00000133019 (Hs) , ENSMUSG00000046159 (Mm) , ENSRNOG00000049410 (Rn)
Protein GI 6978653 (Rn) , 15149489 (Mm) , 4502819 (Hs)
GPCRdb acm3_human (Hs) , acm3_mouse (Mm) , acm3_rat (Rn)
Orphanet 299148 (Hs)
UniProtKB ID/Entry name ACM3_HUMAN (Hs) , ACM3_MOUSE (Mm) , ACM3_RAT (Rn)
DrugBank Target P20309 (Hs)
ChEMBL Target CHEMBL245 (Hs) , CHEMBL320 (Rn) , CHEMBL5105 (Mm)
Target ID 16
名称 M4 receptor
缩写名 SHP2
家族 Acetylcholine receptors (muscarinic)
别名 5-HT1Dα
基因和蛋白信息
Species Transmembrane Domains Amino Acids Chromosomal Location Gene Symbol Gene Name
Rat 7 478 3q24 Chrm4 cholinergic receptor, muscarinic 4
Human 7 479 11p11.2 CHRM4 cholinergic receptor muscarinic 4
Mouse 7 479 2 50.63 cM Chrm4 cholinergic receptor, muscarinic 4
RefSeq Protein NP_113735 (Rn) , NP_000732 (Hs) , NP_031725 (Mm)
UniProtKB P08485 (Rn) , P08173 (Hs) , P32211 (Mm)
OMIM 118495 (Hs)
RefSeq Nucleotide NM_000741 (Hs) , NM_031547 (Rn) , NM_007699 (Mm)
Entrez Gene 1132 (Hs) , 25111 (Rn) , 12672 (Mm)
Ensembl Gene ENSG00000180720 (Hs) , ENSMUSG00000040495 (Mm) , ENSRNOG00000017556 (Rn)
Protein GI 158186623 (Rn) , 52426748 (Hs) , 6680940 (Mm)
GPCRdb acm4_human (Hs) , acm4_mouse (Mm)
UniProtKB ID/Entry name ACM4_HUMAN (Hs) , ACM4_MOUSE (Mm) , ACM4_RAT (Rn)
DrugBank Target P08173 (Hs)
ChEMBL Target CHEMBL4572 (Mm) , CHEMBL1821 (Hs) , CHEMBL317 (Rn)
Target ID 17
名称 M5 receptor
缩写名 SHP2
家族 Acetylcholine receptors (muscarinic)
别名 5-HT1Dα
基因和蛋白信息
Species Transmembrane Domains Amino Acids Chromosomal Location Gene Symbol Gene Name
Rat 7 531 3q35 Chrm5 cholinergic receptor, muscarinic 5
Human 7 532 15q14 CHRM5 cholinergic receptor muscarinic 5
Mouse 7 532 2 57.02 cM Chrm5 cholinergic receptor, muscarinic 5
RefSeq Protein NP_059058 (Rn) , NP_036257 (Hs) , NP_991352 (Mm)
UniProtKB P08911 (Rn) , P08912 (Hs) , Q920H4 (Mm)
OMIM 118496 (Hs)
RefSeq Nucleotide NM_012125 (Hs) , NM_017362 (Rn) , NM_205783 (Mm)
Entrez Gene 1133 (Hs) , 53949 (Rn) , 213788 (Mm)
Ensembl Gene ENSG00000184984 (Hs) , ENSMUSG00000074939 (Mm) , ENSRNOG00000006397 (Rn)
Protein GI 8393123 (Rn) , 254675187 (Mm) , 7108336 (Hs)
GPCRdb acm5_human (Hs) , acm5_mouse (Mm) , acm5_rat (Rn)
UniProtKB ID/Entry name ACM5_HUMAN (Hs) , ACM5_MOUSE (Mm) , ACM5_RAT (Rn)
DrugBank Target P08912 (Hs)
ChEMBL Target CHEMBL2035 (Hs) , CHEMBL277 (Rn)
Target ID 25
名称 α2A-adrenoceptor
缩写名 SHP2
家族 Adrenoceptors
基因和蛋白信息
Species Transmembrane Domains Amino Acids Chromosomal Location Gene Symbol Gene Name
Rat 7 465 1q55 Adra2a adrenoceptor alpha 2A
Human 7 465 10q25.2 ADRA2A adrenoceptor alpha 2A
Mouse 7 465 19 49.04 cM Adra2a adrenergic receptor, alpha 2a
RefSeq Protein NP_036871 (Rn) , NP_000672 (Hs) , NP_031443 (Mm)
UniProtKB P22909 (Rn) , P08913 (Hs) , Q01338 (Mm)
OMIM 104210 (Hs)
RefSeq Nucleotide NM_000681 (Hs) , NM_012739 (Rn) , NM_007417 (Mm)
Entrez Gene 150 (Hs) , 25083 (Rn) , 11551 (Mm)
Ensembl Gene ENSG00000150594 (Hs) , ENSMUSG00000033717 (Mm) , ENSRNOG00000047545 (Rn)
Protein GI 194353957 (Mm) , 194353970 (Hs) , 340805866 (Rn)
GPCRdb ada2a_human (Hs) , ada2a_mouse (Mm) , ada2a_rat (Rn)
UniProtKB ID/Entry name ADA2A_HUMAN (Hs) , ADA2A_MOUSE (Mm) , ADA2A_RAT (Rn)
DrugBank Target P08913 (Hs) , P08913 (Hs) , P08913 (Hs)
ChEMBL Target CHEMBL1867 (Hs) , CHEMBL327 (Rn) , CHEMBL4075 (Mm)
Target ID 428
名称 Glycine Receptor (All subtypes)
缩写名 SHP2
家族 Glycine receptors

关联配体

Ligand ID 320
名称 atropine
别名 hyoscyamine
类别 Natural product
学名 [(1R,5S)-8-methyl-8-azabicyclo[3.2.1]octan-3-yl] 3-hydroxy-2-phenylpropanoate
生物活性评价 The sulfonamide class of antibacterial compounds are primarily bacteriostatic agents and have a broad spectrum of activity against both Gram-positive and Gram-negative species of bacteria (reviewed in ).
评价 Atropine is a muscarinic acetylcholine receptor (mAChR) antagonist.

参考文献

1. Carr BJ, Mihara K, Ramachandran R, Saifeddine M, Nathanson NM, Stell WK, Hollenberg MD.  (2018)  Myopia-Inhibiting Concentrations of Muscarinic Receptor Antagonists Block Activation of Alpha2A-Adrenoceptors In Vitro..  Invest Ophthalmol Vis Sci,  59  (7):  (2778-2791).  [PMID:29860464]
2. Radzicki D et al..  (2017)  Loss of M1 Receptor Dependent Cholinergic Excitation Contributes to mPFC Deactivation in Neuropathic Pain..  J Neurosci,  37  (9):  (2292-2304).  [PMID:28137966]
3. Huang H et al..  (2019)  M1 Macrophage Activated by Notch Signal Pathway Contributed to Ventilator-Induced Lung Injury in Chronic Obstructive Pulmonary Disease Model..  J Surg Res,  244  ():  (358-367).  [PMID:31323391]
4. Wang YJ et al..  (2017)  The Analgesic Effects of (5R,6R)6-(3-Propylthio-1,2,5-thiadiazol-4-yl)-1-azabicyclo[3.2.1] Octane on a Mouse Model of Neuropathic Pain..  Anesth Analg,  124  (4):  (1330-1338).  [PMID:28002166]

相关文档

质检报告COA

请输入批号:


 SDS中文版  SDS英文版

 质量技术规格说明书

你可能也会对下面相关产品感兴趣!

产品问答

产品问答

登录提交问题 Hover me 请先登录再提交问题
查看全部
您提交该产品问题后,我们会在1-2个工作日内给您答复,您可以登录"我的账号",然后点击"我的产品问答"查看答案
上海阿拉丁生化科技股份有限公司
销售条款及条件 ? ? ? ? 隐私政策
? 2016 ALADDIN-E.COM . 版权所有,未经授权禁止拷贝本站资料,如有违反,将追究法律责任
沪公网安备 31012002004058号 沪ICP备09093490号-2

本网站销售的所有产品仅用于工业应用或者科学研究等非医疗目的,不可用于人类或动物的临床诊断或者治疗,非药用,非食用。

上海工商 危险品化学品经营许可证（带存储）营业执照(三证合一)

91高清自产国产拍,无码免费A级毛片大全,日本 欧美 国产中文字幕,99re热视频这里只有精品视频首页

品牌简介

{转码主词}