Species	Transmembrane Domains	Amino Acids	Chromosomal Location	Gene Symbol	Gene Name
Rat	7	589	17q12.1	Chrm3	cholinergic receptor, muscarinic 3
Human	7	590	1q43	CHRM3	cholinergic receptor muscarinic 3
Mouse	7	589	13 3.72 cM	Chrm3	cholinergic receptor, muscarinic 3, cardiac

RefSeq Protein	NP_036659 (Rn) , NP_000731 (Hs) , NP_150372 (Mm)
UniProtKB	P08483 (Rn) , P20309 (Hs) , Q9ERZ3 (Mm)
OMIM	118494 (Hs)
RefSeq Nucleotide	NM_000740 (Hs) , NM_012527 (Rn) , NM_033269 (Mm)
Entrez Gene	1131 (Hs) , 24260 (Rn) , 12671 (Mm)
Ensembl Gene	ENSG00000133019 (Hs) , ENSMUSG00000046159 (Mm) , ENSRNOG00000049410 (Rn)
Protein GI	6978653 (Rn) , 15149489 (Mm) , 4502819 (Hs)
GPCRdb	acm3_human (Hs) , acm3_mouse (Mm) , acm3_rat (Rn)
Orphanet	299148 (Hs)
UniProtKB ID/Entry name	ACM3_HUMAN (Hs) , ACM3_MOUSE (Mm) , ACM3_RAT (Rn)
DrugBank Target	P20309 (Hs)
ChEMBL Target	CHEMBL245 (Hs) , CHEMBL320 (Rn) , CHEMBL5105 (Mm)

Ligand Id	Ligand	Ligand Type	Action on Target	对应产品货号	产品名称
286	(+)-aceclidine	Synthetic organic	Full agonist	Q195196	乙酰克里定
288	(-)-aceclidine	Synthetic organic	Partial agonist
290	McN-A-343	Synthetic organic	Partial agonist	M288419	McN-A 343,M1毒蕈碱激动剂
291	NNC 11-1314	Synthetic organic	Full agonist	N612337	NNC 11-1314
292	NNC 11-1585	Synthetic organic	Full agonist	N612338	NNC 11-1585
293	NNC 11-1607	Synthetic organic	Full agonist	N612339	NNC 11-1607
294	acetylcholine	Metabolite	Full agonist	A607371	acetylcholine
294	acetylcholine	Metabolite	Full agonist	A607371	acetylcholine
295	arecaidine propargyl ester	Synthetic organic	Full agonist	A607719	arecaidine propargyl ester
296	arecoline	Natural product	Full agonist	A348021	槟榔碱
297	bethanechol	Synthetic organic	Full agonist	B608029	bethanechol
298	carbachol	Synthetic organic	Full agonist
298	carbachol	Synthetic organic	Full agonist
299	furtrethonium	Synthetic organic	Full agonist	F610424	furtrethonium
300	methylfurmethide	Synthetic organic	Full agonist	M288210	5-甲基呋喃碘化物
301	milameline	Synthetic organic	Partial agonist	M349090	盐酸米拉米林
302	oxotremorine	Synthetic organic	Full agonist	O612582	oxotremorine
303	oxotremorine-M	Synthetic organic	Full agonist
304	pentylthio-TZTP	Synthetic organic	Full agonist	P612695	pentylthio-TZTP
305	pilocarpine	Synthetic organic	Partial agonist	P344660	毛果芸香碱
306	sabcomeline	Synthetic organic	Partial agonist	S613389	sabcomeline
57	xanomeline	Synthetic organic	Partial agonist	X614889	xanomeline
307	4-DAMP	Synthetic organic	Antagonist	D607186	4-DAMP
308	p-F-HHSiD	Synthetic organic	Antagonist	P335723	对氟六氢-西拉-二苯尼多盐酸盐
308	p-F-HHSiD	Synthetic organic	Antagonist	P335723	对氟六氢-西拉-二苯尼多盐酸盐
309	otenzepad	Synthetic organic	Antagonist	D132744
309	otenzepad	Synthetic organic	Antagonist	D132744
310	hexahydrosiladifenidol	Synthetic organic	Antagonist	H610822	hexahydrosiladifenidol
316	N-methyl scopolamine	Synthetic organic	Antagonist	N612327	N-methyl scopolamine
317	[3H]N-methyl scopolamine	Synthetic organic	Antagonist
317	[3H]N-methyl scopolamine	Synthetic organic	Antagonist
318	[3H]QNB	Synthetic organic	Antagonist
319	[3H]darifenacin	Synthetic organic	Antagonist	H614086	[3H]darifenacin
320	atropine	Natural product	Antagonist	A135946	阿托品
320	atropine	Natural product	Antagonist	A135946	阿托品
366	clidinium	Synthetic organic	Antagonist	C608588	clidinium
321	darifenacin	Synthetic organic	Antagonist	D125652	达非那新
322	hexahydrodifenidol	Synthetic organic	Antagonist	H610821	hexahydrodifenidol
323	hexocyclium	Synthetic organic	Antagonist	H610825	hexocyclium
324	himbacine	Natural product	Antagonist	H329511	Himbacine
325	ipratropium	Synthetic organic	Antagonist	I611132	ipratropium
326	lithocholylcholine	Synthetic organic	Antagonist	L611548	lithocholylcholine
326	lithocholylcholine	Synthetic organic	Antagonist	L611548	lithocholylcholine
327	methoctramine	Synthetic organic	Antagonist	M611820	methoctramine
328	pirenzepine	Synthetic organic	Antagonist	P343027	哌仑西平
328	pirenzepine	Synthetic organic	Antagonist	P343027	哌仑西平
329	propantheline	Synthetic organic	Antagonist	P334974	丙美卡因
330	scopolamine	Natural product	Antagonist	S302239	东莨菪碱氢溴酸盐
331	silahexocyclium	Synthetic organic	Antagonist	S613583	silahexocyclium
367	tiotropium	Synthetic organic	Antagonist	T614468	tiotropium
332	N-benzyl brucine	Natural product	Positive	N611081	N-benzyl brucine
332	N-benzyl brucine	Natural product	Negative	N611081	N-benzyl brucine
335	Gö 7874	Synthetic organic	Negative	G610629	Go 7874
339	WIN 51,708	Synthetic organic	Negative	W614844	WIN 51,708
340	WIN 62,577	Synthetic organic	Positive	W614846	WIN 62,577
341	alcuronium	Natural product	Negative	A607498	alcuronium
342	brucine	Natural product	Negative
343	brucine N-oxide	Synthetic organic	Neutral	B608230	brucine N-oxide
343	brucine N-oxide	Synthetic organic	Positive	B608230	brucine N-oxide
344	N-chloromethyl-brucine	Natural product	Positive	N612190	N-chloromethyl-brucine
345	vinburnine	Synthetic organic	Neutral	E348350	长春布宁
347	strychnine	Natural product	Negative
348	thiochrome	Synthetic organic	Neutral	T344126	硫色素
349	vincamine	Natural product	Neutral	V107385	长春胺
307	4-DAMP	Synthetic organic	Antagonist	D607186	4-DAMP
313	muscarinic toxin 3	Peptide	Antagonist	rp174565	muscarinic toxin 3
361	tripitramine	Synthetic organic	Antagonist	T614545	tripitramine
3264	AFDX384	Synthetic organic	Antagonist	A274921	AF-DX 384,M 2 / M 4拮抗剂
3274	VU0255035	Synthetic organic	Antagonist	V275278	VU0255035,毒蕈碱M 1拮抗剂
3276	guanylpirenzepine	Synthetic organic	Antagonist	G610752	guanylpirenzepine
314	muscarinic toxin 7	Peptide	Antagonist	rp174566	muscarinic toxin 7
7128	biperiden	Synthetic organic	Antagonist	B343587	比哌立登
355	dicyclomine	Synthetic organic	Antagonist	D609875	dicyclomine
7319	tropicamide	Synthetic organic	Antagonist	T123278	托吡卡胺
7354	umeclidinium	Synthetic organic	Antagonist	U614659	umeclidinium
7438	methacholine	Synthetic organic	Agonist	M611809	methacholine
7449	aclidinium	Synthetic organic	Antagonist	A607379	aclidinium
359	oxybutynin	Synthetic organic	Antagonist	O129945	奥昔布宁
7459	glycopyrrolate	Synthetic organic	Antagonist	G610600	glycopyrrolate
7483	solifenacin	Synthetic organic	Antagonist	S413250	索利那新
7549	dosulepin	Synthetic organic	Antagonist	D131853	Dothiepin
200	amitriptyline	Synthetic organic	Antagonist	A413377	阿米替林
7632	VU0119498	Synthetic organic	Positive	V275294	VU0119498,M 1毒蕈碱受体激动剂
7483	solifenacin	Synthetic organic	Antagonist	S413250	索利那新
360	tolterodine	Synthetic organic	Antagonist	T166720	Tolterodine-L-酒石酸盐
8583	UH-AH 37	Synthetic organic	Antagonist	U614647	UH-AH 37
8584	AQ-RA 741	Synthetic organic	Antagonist	A274676	AQ-RA 741,M 2拮抗剂
8586	AE9C90CB	Synthetic organic	Antagonist	A607431	AE9C90CB
8591	ML381	Synthetic organic	Antagonist	M611951	ML381
8592	[3H]tiotropium	Synthetic organic	Antagonist
9658	cevimeline	Synthetic organic	Agonist
10104	(S)-dimetindene	Synthetic organic	Antagonist	D339321	（S）-（+）-马来酸二甲茚
10129	revefenacin	Synthetic organic	Antagonist	R413254	雷芬那辛
10470	mepenzolic acid	Synthetic organic	Antagonist	M611790	mepenzolic acid
6937	iperoxo	Synthetic organic	Agonist	I611129	iperoxo
11497	[3H]4-DAMP	Synthetic organic	Antagonist
12165	CHF-6366	Synthetic organic	Antagonist	R608524	4-[[(2R)-2-hydroxy-2-(8-hydroxy-2-oxo-1H-quinolin-5-yl)ethyl]amino]butyl 5-[[3-[(S)-[[(3R)-1-azabicyclo[2.2.2]octan-3-yl]oxycarbonylamino]-phenylmethyl]phenoxy]methyl]-1-methylpyrazole-3-carboxylate
12486	[3H]iperoxo	Synthetic organic	Agonist	H614138	[3H]iperoxo
8593	[3H]acetylcholine	Synthetic organic	Agonist

1. Stam NJ, Van Huizen F, Van Alebeek C, Brands J, Dijkema R, Tonnaer JA, Olijve W.  (1992)  Genomic organization, coding sequence and functional expression of human 5-HT2 and 5-HT1A receptor genes..  Eur J Pharmacol,  227  (2):  (153-62).  [PMID:1330647]