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乙酰水杨酸

规格或纯度: 用于植物细胞培养, ≥99.0%
有货

库存信息

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库存信息

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货号 (SKU) 包装规格 是否现货 价格 数量
A118582-250g 250g 现货 Stock Image
A118582-1kg 1kg 现货 Stock Image
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ASIC3 Channel blocker COX-1 Inhibitor COX-2 Inhibitor
main product photo

基本描述

规格或纯度 用于植物细胞培养, ≥99.0%
英文名称 Acetylsalicylic acid
别名 阿司匹林;ASA；2-乙酰氧基苯甲酸；O-乙酰基水杨酸
英文别名 2-Acetoxybenzoic acid;O-Acetylsalicylic acid;Aspirin;ASA
生化机理 通过抑制环加氧酶（前列腺素 H 合成酶）来阻断前列腺素的生成，对 COX-1 亚型具有较高的选择性。可抑制血小板中的 COX-1，从而阻断血栓素的生成和血小板凝集，因此具有抗血栓形成的作用。针对结直肠和其他实体瘤的化学防治剂。
运输条件 常规运输
产品介绍

无气味。微带酸味。在干燥空气中稳定，在潮湿空气中逐渐水解成水杨酸和乙酸。遇沸水或溶于氢氧化钠碱溶液和碳酸碱溶液中全部分解。溶于乙醇、乙醚和氯仿。检定锰。有机合成。 乙酰水杨酸靠抑制环化加氧酶（cyclooxygenase，前列腺素H合成酶)阻止前列腺索的生产，特别是针对COX-1同种型有很高的选择性。其抗血栓效果就是由于抑制了血小板中起凝血和血小板凝聚作用的COX-1。

Aspirin is an antiinflammatory compound that inhibits NFκB, cylooxygenase-1 (Cox-1), and cyclooxygenase-2 (Cox-2). NFκB is a transcription factor that plays an important role in the expression of cellular and viral genes, which regulate the inflammatory response and infection. Adhesion molecules IL-1 and IL-6 are genes regulated by NFκB. Along with sodium salicylate, aspirin has been shown to block the long terminal repeat from the human immunodeficiency virus and the Ig κ enhancer from NFκB dependent transcription. Research indicates that aspirin acts at a site downstream of glutamate receptors and blocks induction of NFκB mediated by glutamate. Additional studies suggest that aspirin and sodium salicylate specifically inhibit IKKβ, which results in the blocking of NFκB genes responsible for the inflammatory response. Aspirin has also been described to elevate extracellular adenosine levels, downregulate the expression and activity of inducible NOS, decrease the levels of adenosine triphosphate, act on multiple mitogen-activated protein kinase activities, and block the uncoupling of oxidative phosphorylation. Studies reveal that aspirin alters the equilibrium of Mcl-1/Noxa, giving rise to apoptosis of leukemia cells, independent of NFκB and MAPKs.
An inhibitor of COX-1 (cylooxygenase) and NFκB.

名称和标识符

EC号 200-064-1
IUPAC Name 2-acetyloxybenzoic acid
INCHI InChI=1S/C9H8O4/c1-6(10)13-8-5-3-2-4-7(8)9(11)12/h2-5H,1H3,(H,11,12)
InChi Key BSYNRYMUTXBXSQ-UHFFFAOYSA-N
Canonical SMILES CC(=O)OC1=CC=CC=C1C(=O)O
分子式

C9H8O4
UN Number 2811
PubChem CID 2244
Class 6.1
Packing Group III
Beilstein号 779271
分子量 180.16

化学和物理性质

溶解性 Soluble in 100% ethanol (80mg/ml), DMSO (41mg/ml) or dimethyl formamide (30mg/ml); slightly soluble in PBS, pH 7.2 (2.7mg/ml).
密度 1.35
敏感性 对湿度敏感
熔点 136-140°C
闪点(℉) 446 °F
闪点(℃) 250℃

安全信息

象形图
ghs07

Harmful
信号词 Warning
危险声明 H315: Causes skin irritation
H319: Causes serious eye irritation
H335: May cause respiratory irritation
H302: Harmful if swallowed
预防措施声明 P261,P305+P351+P338,P280,P302+P352,P321,P405,P501,P264,P271,P270,P304+P340,P403+P233,P362+P364,P330,P264+P265,P301+P317,P337+P317,P332+P317,P319
WGK Germany 1
RTECS VO0700000
Reaxy-Rn 779271
Class 6.1
Merck Index 851
个人防护装备 dust mask type N95 (US),Eyeshields,Faceshields,Gloves

靶标

Target ID 686
名称 ASIC3
缩写名 SHP2
家族 Acid-sensing (proton-gated) ion channels (ASICs)
别名 NLR
基因和蛋白信息
Species Transmembrane Domains Amino Acids Chromosomal Location Gene Symbol Gene Name
Human 2 531 7q36.1 ASIC3 acid sensing ion channel subunit 3
Mouse 2 530 5 A3 Asic3 acid-sensing (proton-gated) ion channel 3
Rat 2 533 4q11 Asic3 acid sensing ion channel subunit 3
Entrez Gene 9311 (Hs) , 171209 (Mm) , 286920 (Rn)
OMIM 611741 (Hs)
UniProtKB Q9UHC3 (Hs) , Q6X1Y6 (Mm) , O35240 (Rn)
Ensembl Gene ENSG00000213199 (Hs) , ENSMUSG00000038276 (Mm) , ENSRNOG00000008380 (Rn)
Protein GI 27465601 (Rn) , 9998948 (Hs) , 147905662 (Mm)
DrugBank Target Q9UHC3 (Hs)
ChEMBL Target CHEMBL5368 (Hs) , CHEMBL5757 (Rn) , CHEMBL3232696 (Mm)
Target ID 1375
名称 COX-1
缩写名 SHP2
家族 Cyclooxygenase
别名 DKFZp762B2210
基因和蛋白信息
Species Transmembrane Domains Amino Acids Chromosomal Location Gene Symbol Gene Name
Human 2 599 9q33.2 PTGS1 prostaglandin-endoperoxide synthase 1
Mouse 2 602 2 24.19 cM Ptgs1 prostaglandin-endoperoxide synthase 1
Rat 2 602 3p11 Ptgs1 prostaglandin-endoperoxide synthase 1
Ensembl Gene ENSG00000095303 (Hs) , ENSMUSG00000047250 (Mm) , ENSRNOG00000007415 (Rn)
Entrez Gene 19224 (Mm) , 24693 (Rn) , 5742 (Hs)
OMIM 176805 (Hs)
Protein GI 18104969 (Hs) , 6679537 (Mm) , 94400788 (Rn)
UniProtKB P23219 (Hs) , P22437 (Mm) , Q63921 (Rn)
DrugBank Target P23219 (Hs)
CATH/Gene3D 1.10.640.10 (N/A)
ChEMBL Target CHEMBL2649 (Mm) , CHEMBL4042 (Rn) , CHEMBL221 (Hs)
Target ID 1376
名称 COX-2
缩写名 SHP2
家族 Cyclooxygenase
别名 DKFZp762B2210
基因和蛋白信息
Species Transmembrane Domains Amino Acids Chromosomal Location Gene Symbol Gene Name
Human 2 604 1q31.1 PTGS2 prostaglandin-endoperoxide synthase 2
Mouse 2 604 1 63.84 cM Ptgs2 prostaglandin-endoperoxide synthase 2
Rat 2 604 13q21 Ptgs2 prostaglandin-endoperoxide synthase 2
Ensembl Gene ENSG00000073756 (Hs) , ENSMUSG00000032487 (Mm) , ENSRNOG00000002525 (Rn)
Entrez Gene 19225 (Mm) , 29527 (Rn) , 5743 (Hs)
OMIM 600262 (Hs)
Protein GI 148747270 (Rn) , 4506265 (Hs) , 31981525 (Mm)
UniProtKB P35354 (Hs) , Q05769 (Mm) , P35355 (Rn)
DrugBank Target P35354 (Hs)
CATH/Gene3D 1.10.640.10 (N/A)
ChEMBL Target CHEMBL2977 (Rn) , CHEMBL230 (Hs) , CHEMBL4321 (Mm)

关联配体

Ligand ID 4139
名称 aspirin
别名 acetylsalicylic acid
类别 Synthetic organic
学名 2-acetyloxybenzoic acid
生物活性评价 The sulfonamide class of antibacterial compounds are primarily bacteriostatic agents and have a broad spectrum of activity against both Gram-positive and Gram-negative species of bacteria (reviewed in ).
评价 Aspirin is the prototypical cyclooxygenase inhibitor and inhibits the biosynthesis of prostaglandins. Aspirin acid also inhibits platelet aggregation and is used in the prevention of arterial and venous thrombosis.

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