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aspirin
| 别名 | acetylsalicylic acid, Acetophen®, Aspirin® |
|---|---|
| Compound Class | Synthetic organic |
| 变动原因 | Aspirin is the prototypical cyclooxygenase inhibitor and inhibits the biosynthesis of prostaglandins. Aspirin acid also inhibits platelet aggregation and is used in the prevention of arterial and venous thrombosis. |
| Related Product | 乙酰水杨酸 |
Summary
| 是否批准为药物？ | (FDA (no history prior to 1965)) |
|---|---|
| IUPAC Name | 2-acetyloxybenzoic acid |
| 别名 | acetylsalicylic acid, Acetophen®, Aspirin® |
数据库链接
生物活性
临床资料
| Summary of Clinical Use | Aspirin is used to treat pain, and reduce fever or inflammation. It is also used as a preventative treatment for heart attacks, strokes, and chest pain (angina). |
|---|---|
| 作用机制与药效学效应 | The analgesic, antipyretic, and anti-inflammatory effects of aspirin are due to direct and irreversible inhibition of both cyclooxygenases (COX-1 and COX-2) leading to decreased formation of the precursors of prostaglandins and thromboxanes from arachidonic acid. The main mechanism accounting for platelet aggregation-inhibition by aspirin is irreversible acetylation and inactivation of platelet cyclooxygenase, which blocks the formation of the aggregating agent thromboxane A2. |
结构
| Canonical SMILES | CC(=O)Oc1ccccc1C(=O)O |
|---|---|
| Isomeric SMILES | CC(=O)Oc1ccccc1C(=O)O |
| InChI | InChI=1S/C9H8O4/c1-6(10)13-8-5-3-2-4-7(8)9(11)12/h2-5H,1H3,(H,11,12) |
| InChI key | BSYNRYMUTXBXSQ-UHFFFAOYSA-N |
危险品化学品经营许可证（带存储）