Cas(58-61-7), 腺嘌呤核苷-阿拉丁试剂, 腺苷,Adenosine,

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货号 (SKU)	包装规格	是否现货
A108808-1g	1g	现货
A108808-5g	5g	现货
A108808-25g	25g	现货
A108808-100g	100g	现货
A108808-500g	500g	现货
A108808-2.5kg	2.5kg	现货

货号 (SKU)

包装规格

是否现货

价格

数量

A108808-1g

现货

A108808-5g

现货

A108808-25g

25g

现货

A108808-100g

100g

现货

A108808-500g

500g

现货

A108808-2.5kg

2.5kg

现货

基本描述

规格或纯度	超纯级,99.5%
英文名称	Adenosine
别名	腺苷
英文别名	9-β-D-Ribofuranosyladenine; Adenine riboside; Adenine-9-β-D-ribofuranoside;
应用	An apoptosis inducer and an Adenosine A Receptor activator.
储存温度	2-8°C储存
运输条件	冰袋运输
产品介绍	Adenosine induces apoptosis in human leukemia HL-60 cells. It also has anti-arrhythmic properties. Adenosine is a neurotransmitter that acts as the preferred endogenous agonist at all Adenosine A Receptor subtypes. Adenosine is an activator of Adenosine A2A-R and Adenosine A1-R.An apoptosis inducer and an Adenosine A Receptor activator. Adenosine induces apoptosis in human leukemia HL-60 cells. It also has anti-arrhythmic properties. Adenosine is a neurotransmitter that acts as the preferred endogenous agonist at all Adenosine A Receptor subtypes. Adenosine is an activator of Adenosine A2A-R and Adenosine A1-R. An apoptosis inducer and an Adenosine A Receptor activator.

名称和标识符

EC号	200-389-9
IUPAC Name	(2R,3R,4S,5R)-2-(6-aminopurin-9-yl)-5-(hydroxymethyl)oxolane-3,4-diol
INCHI	InChI=1S/C10H13N5O4/c11-8-5-9(13-2-12-8)15(3-14-5)10-7(18)6(17)4(1-16)19-10/h2-4,6-7,10,16-18H,1H2,(H2,11,12,13)/t4-,6-,7-,10-/m1/s1
InChi Key	OIRDTQYFTABQOQ-KQYNXXCUSA-N
Canonical SMILES	C1=NC(=C2C(=N1)N(C=N2)C3C(C(C(O3)CO)O)O)N
分子式	C₁₀H₁₃N₅O₄
PubChem CID	60961
Beilstein号	93029
分子量	267.24

数据库链接

PubChem CID	60961
Wikipedia	Adenosine
DrugBank Ligand	DB00640
ChEBI	CHEBI:16335
CAS Registry No.	58-61-7
ChEMBL Ligand	CHEMBL477
RCSB PDB Ligand	ADN
PEP	adenosine
DrugCentral Ligand	90
GPCRdb Ligand	adenosine

化学和物理性质

溶解性	Soluble in 1M NH4OH, water (7 mg/ml), and DMSO (75 mM). Insoluble in ethanol.
密度	2.08
熔点	234-236°C
比旋光度	-70 ° (C=2, 5% NaOH)

安全信息

象形图	Harmful
信号词	Warning
危险声明	H315: Causes skin irritation H319: Causes serious eye irritation
预防措施声明	P305+P351+P338,P280,P302+P352,P321,P264,P362+P364,P264+P265,P337+P317,P332+P317
WGK Germany	2
RTECS	AU7175000
Reaxy-Rn	93029
Merck Index	153
个人防护装备	Eyeshields,Gloves,type N95 (US),type P1 (EN143) respirator filter

靶标

Target ID

名称

A₁ receptor

缩写名

SHP2

家族

Adenosine receptors

别名

5-HT_1E_α

基因和蛋白信息

Species	Transmembrane Domains	Amino Acids	Chromosomal Location	Gene Symbol	Gene Name
Rat	7	326	13q13	Adora1	adenosine A1 receptor
Human	7	326	1q32.1	ADORA1	adenosine A1 receptor
Mouse	7	326	1 E4	Adora1	adenosine A1 receptor

RefSeq Protein

NP_058851 (Rn) , NP_000665 (Hs) , NP_001008533 (Mm)

UniProtKB

P25099 (Rn) , P30542 (Hs) , Q60612 (Mm)

OMIM

102775 (Hs)

RefSeq Nucleotide

NM_000674 (Hs) , NM_017155 (Rn) , NM_001008533 (Mm)

Entrez Gene

134 (Hs) , 29290 (Rn) , 11539 (Mm)

Ensembl Gene

ENSG00000163485 (Hs) , ENSMUSG00000042429 (Mm) , ENSRNOG00000003442 (Rn)

Protein GI

115305569 (Hs) , 148540068 (Rn) , 87239994 (Mm)

GPCRdb

aa1r_human (Hs) , aa1r_mouse (Mm) , aa1r_rat (Rn)

UniProtKB ID/Entry name

AA1R_HUMAN (Hs) , AA1R_MOUSE (Mm) , AA1R_RAT (Rn)

DrugBank Target

P30542 (Hs)

ChEMBL Target

CHEMBL318 (Rn) , CHEMBL226 (Hs) , CHEMBL3688 (Mm)

Target ID

名称

A_2A receptor

缩写名

SHP2

家族

Adenosine receptors

别名

5-HT_1E_α

基因和蛋白信息

Species	Transmembrane Domains	Amino Acids	Chromosomal Location	Gene Symbol	Gene Name
Rat	7	410	20p12	Adora2a	adenosine A2a receptor
Human	7	412	22q11.23	ADORA2A	adenosine A2a receptor
Mouse	7	410	10 C1	Adora2a	adenosine A2a receptor

RefSeq Protein

NP_445746 (Rn) , NP_000666 (Hs) , NP_033760 (Mm)

UniProtKB

P30543 (Rn) , P29274 (Hs) , Q60613 (Mm)

OMIM

102776 (Hs)

RefSeq Nucleotide

NM_000675 (Hs) , NM_053294 (Rn) , NM_009630 (Mm)

Entrez Gene

135 (Hs) , 25369 (Rn) , 11540 (Mm)

Ensembl Gene

ENSG00000128271 (Hs) , ENSMUSG00000020178 (Mm) , ENSRNOG00000001302 (Rn)

Protein GI

5921992 (Hs) , 78126172 (Rn) , 126517500 (Mm)

GPCRdb

aa2ar_human (Hs) , aa2ar_mouse (Mm) , aa2ar_rat (Rn)

Orphanet

365126 (Hs)

UniProtKB ID/Entry name

AA2AR_HUMAN (Hs) , AA2AR_MOUSE (Mm) , AA2AR_RAT (Rn)

DrugBank Target

P29274 (Hs)

ChEMBL Target

CHEMBL2115 (Mm) , CHEMBL251 (Hs) , CHEMBL302 (Rn)

Target ID

名称

A_2B receptor

缩写名

SHP2

家族

Adenosine receptors

别名

5-HT_1E_α

基因和蛋白信息

Species	Transmembrane Domains	Amino Acids	Chromosomal Location	Gene Symbol	Gene Name
Rat	7	332	10q23	Adora2b	adenosine A2B receptor
Human	7	332	17p12	ADORA2B	adenosine A2b receptor
Mouse	7	332	11 B2	Adora2b	adenosine A2b receptor

RefSeq Protein

NP_058857 (Rn) , NP_000667 (Hs) , NP_031439 (Mm)

UniProtKB

P29276 (Rn) , P29275 (Hs) , Q60614 (Mm)

OMIM

600446 (Hs)

RefSeq Nucleotide

NM_000676 (Hs) , NM_017161 (Rn) , NM_007413 (Mm)

Entrez Gene

136 (Hs) , 29316 (Rn) , 11541 (Mm)

Ensembl Gene

ENSG00000170425 (Hs) , ENSMUSG00000018500 (Mm) , ENSRNOG00000002922 (Rn)

Protein GI

31560741 (Mm) , 4501951 (Hs) , 8392864 (Rn)

GPCRdb

aa2br_human (Hs) , aa2br_mouse (Mm) , aa2br_rat (Rn)

UniProtKB ID/Entry name

AA2BR_HUMAN (Hs) , AA2BR_MOUSE (Mm) , AA2BR_RAT (Rn)

DrugBank Target

P29275 (Hs)

ChEMBL Target

CHEMBL255 (Hs) , CHEMBL2592 (Rn) , CHEMBL2237 (Mm)

Target ID

名称

A₃ receptor

缩写名

SHP2

家族

Adenosine receptors

别名

5-HT_1E_α

基因和蛋白信息

Species	Transmembrane Domains	Amino Acids	Chromosomal Location	Gene Symbol	Gene Name
Rat	7	320	2q34	Adora3	adenosine A3 receptor
Human	7	318	1p13.2	ADORA3	adenosine A3 receptor
Mouse	7	319	3 46.45 cM	Adora3	adenosine A3 receptor

RefSeq Protein

NP_037028 (Rn) , NP_000668 (Hs) , NP_033761 (Mm)

UniProtKB

P28647 (Rn) , P0DMS8 (Hs) , Q61618 (Mm)

OMIM

600445 (Hs)

RefSeq Nucleotide

NM_000677 (Hs) , NM_012896 (Rn) , NM_009631 (Mm)

Entrez Gene

140 (Hs) , 25370 (Rn) , 11542 (Mm)

Ensembl Gene

ENSMUSG00000000562 (Mm) , ENSRNOG00000015788 (Rn) , ENSG00000282608 (Hs)

Protein GI

130978672 (Hs) , 211063459 (Rn) , 292781462 (Mm)

GPCRdb

aa3r_human (Hs) , aa3r_mouse (Mm) , aa3r_rat (Rn)

UniProtKB ID/Entry name

AA3R_HUMAN (Hs) , AA3R_MOUSE (Mm) , AA3R_RAT (Rn)

DrugBank Target

P0DMS8 (Hs)

ChEMBL Target

CHEMBL3360 (Rn) , CHEMBL1075269 (Mm) , CHEMBL256 (Hs)

Target ID

496

名称

TRPM4

缩写名

SHP2

家族

Transient Receptor Potential channels (TRP)

别名

MIP-1αRL-2 (mouse)

基因和蛋白信息

Species	Transmembrane Domains	Amino Acids	Chromosomal Location	Gene Symbol	Gene Name
Human	6	1214	19q13.33	TRPM4	transient receptor potential cation channel subfamily M member 4
Rat	6	1208	1q22	Trpm4	transient receptor potential cation channel, subfamily M, member 4
Mouse	6	1213	7 B3	Trpm4	transient receptor potential cation channel, subfamily M, member 4

OMIM

606936 (Hs)

Entrez Gene

171143 (Rn) , 68667 (Mm) , 54795 (Hs)

UniProtKB

Q8TD43 (Hs) , Q9ESQ5 (Rn) , Q7TN37 (Mm)

RefSeq Protein

NP_060106 (Hs) , NP_001129701 (Rn) , NP_780339 (Mm)

RefSeq Nucleotide

NM_017636 (Hs) , NM_001136229 (Rn) , NM_175130 (Mm)

Ensembl Gene

ENSG00000130529 (Hs) , ENSMUSG00000038260 (Mm) , ENSRNOG00000020714 (Rn)

Orphanet

209301 (Hs)

Protein GI

304766677 (Hs) , 209977101 (Rn) , 157824093 (Mm)

ChEMBL Target

CHEMBL1628469 (Hs)

Target ID

2498

名称

phosphatidylinositol 4-kinase type 2 alpha

缩写名

PI4KIIα/PI4K2A

家族

Phosphatidylinositol kinases

别名

delta

基因和蛋白信息

Species	Transmembrane Domains	Amino Acids	Chromosomal Location	Gene Symbol	Gene Name
Human	2	479	10q24.2	PI4K2A	phosphatidylinositol 4-kinase type 2 alpha
Mouse	2	479	19 35.74 cM	Pi4k2a	phosphatidylinositol 4-kinase type 2 alpha
Rat	2	478	1q54	Pi4k2a	phosphatidylinositol 4-kinase type 2 alpha

Ensembl Gene

ENSG00000155252 (Hs) , ENSMUSG00000025178 (Mm) , ENSRNOG00000014675 (Rn)

UniProtKB

Q2TBE6 (Mm) , Q99M64 (Rn) , Q9BTU6 (Hs)

Entrez Gene

55361 (Hs) , 84095 (Mm) , 114554 (Rn)

OMIM

609763 (Hs)

RefSeq Nucleotide

NM_018425 (Hs) , NM_053735 (Rn) , NM_145501 (Mm)

RefSeq Protein

NP_060895 (Hs) , NP_446187 (Rn) , NP_663476 (Mm)

Protein GI

13559514 (Hs) , 21703986 (Mm) , 16758554 (Rn)

ChEMBL Target

CHEMBL2251 (Hs)

Target ID

2499

名称

phosphatidylinositol 4-kinase type 2 beta

缩写名

PI4KIIβ/PI4K2B

家族

Phosphatidylinositol kinases

别名

delta

基因和蛋白信息

Species	Transmembrane Domains	Amino Acids	Chromosomal Location	Gene Symbol	Gene Name
Human	2	481	4p15.2	PI4K2B	phosphatidylinositol 4-kinase type 2 beta
Mouse	2	469	5 C1	Pi4k2b	phosphatidylinositol 4-kinase type 2 beta
Rat	2	477	14q11	Pi4k2b	phosphatidylinositol 4-kinase type 2 beta

Ensembl Gene

ENSG00000038210 (Hs) , ENSMUSG00000029186 (Mm) , ENSRNOG00000003924 (Rn)

UniProtKB

Q5XIL2 (Rn) , Q8CBQ5 (Mm) , Q8TCG2 (Hs)

Entrez Gene

55300 (Hs) , 67073 (Mm) , 305419 (Rn)

OMIM

612101 (Hs)

RefSeq Nucleotide

NM_001005883 (Rn) , NM_018323 (Hs) , NM_025951 (Mm)

RefSeq Protein

NP_001005883 (Rn) , NP_060793 (Hs) , NP_080227 (Mm)

Protein GI

224591401 (Hs) , 145966899 (Mm) , 54400734 (Rn)

ChEMBL Target

CHEMBL3220 (Hs)

关联配体

Ligand ID	2844
名称	adenosine
别名	Adenocard®
类别	Metabolite
学名	(2R,3R,4S,5R)-2-(6-aminopurin-9-yl)-5-(hydroxymethyl)oxolane-3,4-diol
生物活性评价	The sulfonamide class of antibacterial compounds are primarily bacteriostatic agents and have a broad spectrum of activity against both Gram-positive and Gram-negative species of bacteria (reviewed in ).
评价	Endogenous nucleoside, a component of nucleic acids and an important neurotransmitter.