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Zaurategrast,抑制剂

Zaurategrast,抑制剂

规格或纯度: ≥99%

CAS编号: 455264-31-0
分子式: C₂₆H₂₅BrN₄O₃
分子量: 521.42
PubChem编号: 10186367

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货号 (SKU)	包装规格	是否现货	价格	数量
Z126002-10mg	10mg	期货
Z126002-50mg	50mg	期货
Z126002-100mg	100mg	期货

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integrin α4β1 Inhibitor integrin α4β7 Inhibitor integrin，alpha 4 subunit (antigen CD49D，alpha 4 subunit of VLA-4 receptor) Inhibitor

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基本描述

规格或纯度	≥99%
英文名称	Zaurategrast
生化机理	Zaurategrast(CDP-323) is an integrin inhibitor.
储存温度	-20°C储存
运输条件	超低温冰袋运输

名称和标识符

IUPAC Name	(2S)-2-[(2-bromo-3-oxospiro[3.5]non-1-en-1-yl)amino]-3-[4-(2,7-naphthyridin-1-ylamino)phenyl]propanoic acid
INCHI	InChI=1S/C26H25BrN4O3/c27-21-22(26(23(21)32)10-2-1-3-11-26)31-20(25(33)34)14-16-4-6-18(7-5-16)30-24-19-15-28-12-8-17(19)9-13-29-24/h4-9,12-13,15,20,31H,1-3,10-11,14H2,(H,29,30)(H,33,34)/t20-/m0/s1
InChi Key	KYHVWHYLKOHLKA-FQEVSTJZSA-N
Canonical SMILES	C1CCC2(CC1)C(=C(C2=O)Br)NC(CC3=CC=C(C=C3)NC4=NC=CC5=C4C=NC=C5)C(=O)O
PubChem CID	10186367
分子量	521.42

数据库链接

PubChem CID	10186367
CAS Registry No.	455264-31-0
ChEMBL Ligand	CHEMBL4303708

化学和物理性质

溶解性	DMSO

安全和危险性（GHS）

象形图	Health Hazard
信号词	Warning
危险声明	H361: Suspected of damaging fertility or the unborn child
预防措施声明	P280,P405,P501,P203,P318

关联配体

Ligand ID	11488
名称	zaurategrast
别名	CDP323
类别	Synthetic organic
学名	(2S)-2-[(2-bromo-3-oxospiro[3.5]non-1-en-1-yl)amino]-3-[4-(2,7-naphthyridin-1-ylamino)phenyl]propanoic acid
生物活性评价	The sulfonamide class of antibacterial compounds are primarily bacteriostatic agents and have a broad spectrum of activity against both Gram-positive and Gram-negative species of bacteria (reviewed in ).
评价	Zaurategrast (CDP-323) is a small molecule inhibitor of α4-containing integrin complexes that was developed by Celltech . It was intended as a new oral drug treatment for multiple sclerosis . Zaurategrast has the same mechanism of action as the approved MS therapeutic . Zaurategrast is an ester prodrug whose active entity is CT7758 .
临床描述	Comparison of the effects of different CDP323 doses given over a period of four weeks on blood biomarkers in subjects with relapsing forms of multiple sclerosis. The objective of the study is to evaluate the effect, safety and tolerability of CDP323 in patients with relapsing forms of multiple sclerosis
来源公司	UCB Pharma UCB Pharma

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参考文献

1. Davenport RJ, Munday JR. (2007) Alpha4-integrin antagonism--an effective approach for the treatment of inflammatory diseases?. Drug Discov Today, 12 (13-14): (569-76). [PMID:17631252]
2. Chanteux H, Staelens L, Mancel V, Gerin B, Boucaut D, Prakash C, Nicolas JM. (2015) Cross-Species Differences in the Preclinical Pharmacokinetics of CT7758, an α4β1/α4β7 Integrin Antagonist.. Drug Metab Dispos, 43 (9): (1381-91). [PMID:26153275]
3. Li H, Huang SY, Shi FH, Gu ZC, Zhang SG, Wei JF. (2018) α₄β₇ integrin inhibitors: a patent review.. Expert Opin Ther Pat, 28 (12): (903-917). [PMID:30444683]

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