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藜芦定

Na +开沟器

规格或纯度: ≥97%

CAS编号: 71-62-5
分子式: C₃₆H₅₁NO₁₁
分子量: 673.8
PubChem编号: 6280

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库存信息

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库存信息

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货号 (SKU)	包装规格	是否现货	价格	数量
V275475-5mg	5mg	现货
V275475-10mg	10mg	现货

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基本描述

规格或纯度	≥97%
英文名称	Veratridine
英文别名	3-Veratroylveracevine；(3S,4S,4aS,6aS,6bS,8R,8aS,9S,9aS,12S,15aS,15bR,16aR,16bR)-4,6b,8,8a,9,15b-hexahydroxy-9,12,16b-trimethyldocosahydro-1H-4,16a-epoxybenzo[4,5]indeno[1,2-h]pyrido[1,2-b]isoquinolin-3-yl 3,4-dimethoxybenzoate
生化机理	百合科植物中发现的生物碱毒素。导致电压门控的Na +通道持续打开，并降低其单通道电导。
储存温度	-20°C储存,干燥
运输条件	超低温冰袋运输
备注	如果有可能，您尽量在使用的当天配置溶液，并在当天使用完它。但是，如果您需要预先配制储备溶液，我们建议您将溶液等份保存在-20°C的密封小瓶中。通常，它们最多可以使用一个月。在使用前和打开样品瓶之前，我们建议您让您的产品在室温下平衡至少1小时。需要更多关于溶解度，用法和处理的建议吗？请访问我们的常见问题（FAQ）页面以获取更多详细信息。
产品介绍	储存在-20℃。存放在干燥的条件下。该产品最多可存储12个月。 Store at -20°C. Store under desiccating conditions. The product can be stored for up to 12 months. Application： A Na+ channel opener. Increases intracellular Ca2+ levels without affecting Na+ - Ca2+ exchange. Acts at neurotoxin receptor site 2 and preferentially binds to activated Na+ channels causing persistent activation. Induces cell death in bovine chromaffin cells. A Na+ channel opener. Increases intracellular Ca2+ levels without affecting Na+-Ca2+ exchange. Acts at neurotoxin receptor site 2 and preferentially binds to activated Na+ channels causing persistent activation. Induces cell death in bovine chromaffin cells.

名称和标识符

IUPAC Name	[(1R,2S,6S,9S,10R,11S,12S,14R,15S,18S,19S,22S,23S,25R)-1,10,11,12,14,23-hexahydroxy-6,10,19-trimethyl-24-oxa-4-azaheptacyclo[12.12.0.02,11.04,9.015,25.018,23.019,25]hexacosan-22-yl] 3,4-dimethoxybenzoate
INCHI	InChI=1S/C36H51NO11/c1-19-6-11-26-31(3,40)35(43)25(17-37(26)16-19)33(42)18-34-24(32(33,41)15-27(35)38)10-9-23-30(34,2)13-12-28(36(23,44)48-34)47-29(39)20-7-8-21(45-4)22(14-20)46-5/h7-8,14,19,23-28,38,40-44H,6,9-13,15-18H2,1-5H3/t19-,23-,24-,25-,26-,27-,28-,30-,31+,32+,33+,34+,35-,36-/m0/s1
InChi Key	FVECELJHCSPHKY-YFUMOZOISA-N
Canonical SMILES	CC1CCC2C(C3(C(CC4(C5CCC6C7(C5(CC4(C3CN2C1)O)OC6(C(CC7)OC(=O)C8=CC(=C(C=C8)OC)OC)O)C)O)O)O)(C)O
PubChem CID	6280
分子量	673.8

数据库链接

PubChem CID	6280
Wikipedia	Veratridine
ChEMBL Ligand	CHEMBL439496
BindingDB Ligand	50158389
CAS Registry No.	71-62-5
ChEBI	CHEBI:28051

化学和物理性质

溶解性	Soluble in ethanol to 100 mM

安全和危险性（GHS）

象形图	Toxic Health Hazard Harmful
信号词	Danger
危险声明	H315: Causes skin irritation H319: Causes serious eye irritation H335: May cause respiratory irritation H300: Fatal if swallowed H310: Fatal in contact with skin H330: Fatal if inhaled H361: Suspected of damaging fertility or the unborn child
预防措施声明	P261,P305+P351+P338,P280,P302+P352,P321,P405,P501,P264,P260,P284,P271,P270,P304+P340,P403+P233,P362+P364,P330,P262,P320,P361+P364,P203,P264+P265,P301+P316,P318,P337+P317,P332+P317,P316,P319

关联配体

Ligand ID	2626
名称	veratridine
别名	veratrine
类别	Natural product
学名	4-amino-N-(4,6-dimethylpyrimidin-2-yl)benzenesulfonamide
生物活性评价	The sulfonamide class of antibacterial compounds are primarily bacteriostatic agents and have a broad spectrum of activity against both Gram-positive and Gram-negative species of bacteria (reviewed in ).
评价	Sulfadimidine (sulfamethazine) is a sulfonamide antibacterial compound. This class of compounds are competitive inhibitors of bacterial dihydropteroate synthase (DHPS), an enzyme in the pathway which generates the folic acid that is essential for bacterial growth.

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参考文献

1. Wei XP et al.. (2022) A novel reticular node in the brainstem synchronizes neonatal mouse crying with breathing.. Neuron, 110 (4): (644-657.e6). [PMID:34998469]
2. Mohammed ZA et al.. (2020) An unbiased and efficient assessment of excitability of sensory neurons for analgesic drug discovery.. Pain, 161 (5): (1100-1108). [PMID:31929383]
3. Zimmermann K et al.. (2013) Analgesic treatment of ciguatoxin-induced cold allodynia.. Pain, 154 (10): (1999-2006). [PMID:23778293]
4. Sousa SR et al.. (2017) Discovery and mode of action of a novel analgesic ?-toxin from the African spider Ceratogyrus darlingi.. PLoS One, 12 (9): (e0182848). [PMID:28880874]
5. Henriques ST et al.. (2016) Interaction of Tarantula Venom Peptide ProTx-II with Lipid Membranes Is a Prerequisite for Its Inhibition of Human Voltage-gated Sodium Channel NaV1.7.. J Biol Chem, 291 (33): (17049-65). [PMID:27311819]
6. Mohammed ZA et al.. (2017) Veratridine produces distinct calcium response profiles in mouse Dorsal Root Ganglia neurons.. Sci Rep, 7 (): (45221). [PMID:28338073]