首页
400-620-6333
切换导航
搜索
基本描述
| 规格或纯度 | 98% |
|---|---|
| 英文名称 | Verlukast |
| 别名 | 3-[[(R)-[3-[(1E)-2-(7-Chloro-2-quinolinyl)ethenyl]phenyl][[3-(dimethylamino)-3-oxopropyl]thio]methyl]thio]-propanoic Acid; L 668019; MK 679; R-(-)-MK 571 |
| 英文别名 | 3-[[(R)-[3-[(1E)-2-(7-Chloro-2-quinolinyl)ethenyl]phenyl][[3-(dimethylamino)-3-oxopropyl]thio]methyl]thio]-propanoic Acid; L 668019; MK 679; R-(-)-MK 571 |
| 生化机理 |
Verlukast(MK-679; L 668019) is a receptor antagonist for the treatment of respiratory diseases. |
| 储存温度 | -20°C储存 |
| 运输条件 | 超低温冰袋运输 |
| 产品介绍 |
Product Application: A receptor antagonist for the treatment of respiratory diseases. |
名称和标识符
| IUPAC Name | 3-[(R)-[3-[(E)-2-(7-chloroquinolin-2-yl)ethenyl]phenyl]-[3-(dimethylamino)-3-oxopropyl]sulfanylmethyl]sulfanylpropanoic acid |
|---|---|
| INCHI | InChI=1S/C26H27ClN2O3S2/c1-29(2)24(30)12-14-33-26(34-15-13-25(31)32)20-5-3-4-18(16-20)6-10-22-11-8-19-7-9-21(27)17-23(19)28-22/h3-11,16-17,26H,12-15H2,1-2H3,(H,31,32)/b10-6+/t26-/m1/s1 |
| InChi Key | AXUZQJFHDNNPFG-LHAVAQOQSA-N |
| Canonical SMILES | CN(C)C(=O)CCSC(C1=CC=CC(=C1)C=CC2=NC3=C(C=CC(=C3)Cl)C=C2)SCCC(=O)O |
| 分子式 |
C26H27ClN2O3S2 |
| PubChem CID | 6509849 |
| 分子量 | 515.09 |
数据库链接
| CAS Registry No. | 120443-16-5 |
|---|---|
| PubChem CID | 6509849 |
| ChEMBL Ligand | CHEMBL280481 |
| Reactome Reaction | R-HSA-9684627 |
| Reactome Drug | R-ALL-9684617 |
| GPCRdb Ligand | verlukast |
化学和物理性质
| 溶解性 | DMSO (Slightly), Methanol (Slightly, Heated, Sonicated), THF (Slightly, Sonicate) |
|---|---|
| 熔点 | 57-62°C |
靶标
| Target ID | 269 | ||||||||||||||||||||||||
|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|
| 名称 | CysLT1 receptor | ||||||||||||||||||||||||
| 缩写名 | SHP2 | ||||||||||||||||||||||||
| 家族 | Leukotriene receptors | ||||||||||||||||||||||||
| 别名 | α2-C4 | ||||||||||||||||||||||||
| 基因和蛋白信息 |
|
||||||||||||||||||||||||
| RefSeq Protein | NP_446093 (Rn) , NP_006630 (Hs) , NP_067451 (Mm) | ||||||||||||||||||||||||
| UniProtKB | Q924T8 (Rn) , Q9Y271 (Hs) , Q99JA4 (Mm) | ||||||||||||||||||||||||
| OMIM | 300201 (Hs) | ||||||||||||||||||||||||
| RefSeq Nucleotide | NM_006639 (Hs) , NM_053641 (Rn) , NM_021476 (Mm) | ||||||||||||||||||||||||
| Entrez Gene | 10800 (Hs) , 114099 (Rn) , 58861 (Mm) | ||||||||||||||||||||||||
| Ensembl Gene | ENSG00000173198 (Hs) , ENSMUSG00000052821 (Mm) , ENSRNOG00000037845 (Rn) | ||||||||||||||||||||||||
| Protein GI | 16758452 (Rn) , 5729798 (Hs) , 31542449 (Mm) | ||||||||||||||||||||||||
| GPCRdb | cltr1_human (Hs) , cltr1_mouse (Mm) , cltr1_rat (Rn) | ||||||||||||||||||||||||
| UniProtKB ID/Entry name | CLTR1_HUMAN (Hs) , CLTR1_MOUSE (Mm) , CLTR1_RAT (Rn) | ||||||||||||||||||||||||
| DrugBank Target | Q9Y271 (Hs) | ||||||||||||||||||||||||
| ChEMBL Target | CHEMBL1075218 (Rn) , CHEMBL1798 (Hs) , CHEMBL3808269 (Mm) |
| Target ID | 1224 | ||||||||||||||||||
|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|
| 名称 | OATP2B1 | ||||||||||||||||||
| 缩写名 | SHP2 | ||||||||||||||||||
| 家族 | SLCO family of organic anion transporting polypeptides | ||||||||||||||||||
| 别名 | KPG_010 | ||||||||||||||||||
| 基因和蛋白信息 |
|
||||||||||||||||||
| Ensembl Gene | ENSG00000137491 (Hs) , ENSMUSG00000030737 (Mm) | ||||||||||||||||||
| Entrez Gene | 101488 (Mm) , 140860 (Rn) , 11309 (Hs) | ||||||||||||||||||
| OMIM | 604988 (Hs) | ||||||||||||||||||
| Protein GI | 18158457 (Rn) , 223634014 (Hs) , 357527420 (Mm) | ||||||||||||||||||
| UniProtKB | O94956 (Hs) , Q8BXB6 (Mm) , Q9JHI3 (Rn) | ||||||||||||||||||
| DrugBank Target | O94956 (Hs) | ||||||||||||||||||
| Bioparadigms SLC Tables | SLCO2B1 (Hs) | ||||||||||||||||||
| RESOLUTE | SLCO2B1 (Hs) | ||||||||||||||||||
| ChEMBL Target | CHEMBL1743124 (Hs) , CHEMBL2073698 (Rn) |
关联配体
| Ligand ID | 6193 |
|---|---|
| 名称 | verlukast |
| 别名 | MK-679 |
| 类别 | Synthetic organic |
| 学名 | 3-[(R)-[3-[(E)-2-(7-chloroquinolin-2-yl)ethenyl]phenyl]-(3-dimethylamino-3-oxopropyl)sulfanylmethyl]sulfanylpropanoic acid |
| 生物活性评价 |
The sulfonamide class of antibacterial compounds are primarily bacteriostatic agents and have a broad spectrum of activity against both Gram-positive and Gram-negative species of bacteria (reviewed in |
| 评价 |
Verlukast (MK-679) is a potent CysLT1 (LTD4) receptor inverse agonist; also MRP1 inhibitor. It is the (R)-enantiomer of |
参考文献
| 1. Jones TR, Zamboni R, Belley M, Champion E, Charette L, Ford-Hutchinson AW, Gauthier JY, Leger S, Lord A, Masson P et al.. (1991) Pharmacology of the leukotriene antagonist verlukast: the (R)-enantiomer of MK-571.. Can J Physiol Pharmacol, 69 (12): (1847-54). [PMID:1666333] |
相关文档
产品问答
产品问答
上海阿拉丁生化科技股份有限公司
? 2016 ALADDIN-E.COM . 版权所有,未经授权禁止拷贝本站资料,如有违反,将追究法律责任
危险品化学品经营许可证（带存储）