91高清自产国产拍,无码免费A级毛片大全,日本 欧美 国产中文字幕,99re热视频这里只有精品视频首页

首页   400-620-6333
提交您使用阿拉丁产品的研究文章，就得100元奖励！立即访问我们的提交页面.
语言
Chinese
切换导航
我的购物车
搜索
搜索444
高级搜索
菜单
账号
设置
语言
Chinese

维拉佐酮

规格或纯度: ≥98%
有货

库存信息

关闭

库存信息

关闭
货号 (SKU) 包装规格 是否现货 价格 数量
V124992-10mg
 10mg 现货 Stock Image
V124992-50mg
 50mg 现货 Stock Image
大包装询价 添加到收藏夹 比较  SDS中文版  DATASHEET
查看相关系列
5-HT1A receptor Agonist 5-HT4 receptor Agonist D2 receptor Agonist D3 receptor Agonist H1 receptor Agonist SERT Inhibitor
main product photo

基本描述

规格或纯度 ≥98%
英文名称 Vilazodone
别名 维拉佐酮
英文别名 Vilazodone|163521-12-8|5-(4-(4-(5-Cyano-1H-indol-3-yl)butyl)piperazin-1-yl)benzofuran-2-carboxamide|EMD 515259|vilazodona|vilazodonum|UNII-S239O2OOV3|EMD-515259|EMD-68-843|S239O2OOV3|CHEBI:70707|HSDB 8197|5-{4-[4-(5-cyano-1H-indol-3-yl)butyl]piperazin-1-y
生化机理 Vilazodone (EMD 68843; SB 659746A; 5-{4-[4-(5-cyano-3-indolyl)-butyl]-1-piperazinyl}-benzofuran-2-carboxamide hydrochloride) is a combined serotonin specific reuptake inhibitor (SSRI) and 5-HT1A receptor partial agonist currently under clinical evaluation for the treatment of major depression.
储存温度 -20°C储存
运输条件 超低温冰袋运输
产品介绍

Vilazodone is an inhibitor of ST (serotonin transporter and uptake) (IC50 = 0.5 nM) and SR-1A activator (partial agonist) (IC50 = 0.2 nM; IA = ~60-70%).An inhibitor of ST and activator of SR-1A

Vilazodone is an inhibitor of ST (serotonin transporter and uptake) (IC50 = 0.5 nM) and SR-1A activator (partial agonist) (IC50 = 0.2 nM; IA = ~60-70%).
An inhibitor of ST and activator of SR-1A

名称和标识符

IUPAC Name 5-[4-[4-(5-cyano-1H-indol-3-yl)butyl]piperazin-1-yl]-1-benzofuran-2-carboxamide
INCHI InChI=1S/C26H27N5O2/c27-16-18-4-6-23-22(13-18)19(17-29-23)3-1-2-8-30-9-11-31(12-10-30)21-5-7-24-20(14-21)15-25(33-24)26(28)32/h4-7,13-15,17,29H,1-3,8-12H2,(H2,28,32)
InChi Key SGEGOXDYSFKCPT-UHFFFAOYSA-N
Canonical SMILES C1CN(CCN1CCCCC2=CNC3=C2C=C(C=C3)C#N)C4=CC5=C(C=C4)OC(=C5)C(=O)N
PubChem CID 6918314
分子量 441.52

化学和物理性质

溶解性 DMSO

关联配体

Ligand ID 7427
名称 vilazodone
别名 EMD-68-843
类别 Synthetic organic
学名 5-[4-[4-(5-cyano-1H-indol-3-yl)butyl]piperazin-1-yl]-1-benzofuran-2-carboxamide
生物活性评价 The sulfonamide class of antibacterial compounds are primarily bacteriostatic agents and have a broad spectrum of activity against both Gram-positive and Gram-negative species of bacteria (reviewed in ).
评价 Note that the USAN (United States Adopted Name) refers to the hydrochloride salt which has PubChem CID 6918313.

产品问答

产品问答

登录提交问题 Hover me 请先登录再提交问题
查看全部
您提交该产品问题后,我们会在1-2个工作日内给您答复,您可以登录"我的账号",然后点击"我的产品问答"查看答案

参考文献

1. Dawson LA, Watson JM.  (2009)  Vilazodone: a 5-HT1A receptor agonist/serotonin transporter inhibitor for the treatment of affective disorders..  CNS Neurosci Ther,  15  (2):  (107-17).  [PMID:19499624]
2. Heinrich T, B?ttcher H, Gericke R, Bartoszyk GD, Anzali S, Seyfried CA, Greiner HE, Van Amsterdam C.  (2004)  Synthesis and structure--activity relationship in a class of indolebutylpiperazines as dual 5-HT(1A) receptor agonists and serotonin reuptake inhibitors..  J Med Chem,  47  (19):  (4684-92).  [PMID:15341484]
3. Hughes ZA, Starr KR, Langmead CJ, Hill M, Bartoszyk GD, Hagan JJ, Middlemiss DN, Dawson LA.  (2005)  Neurochemical evaluation of the novel 5-HT1A receptor partial agonist/serotonin reuptake inhibitor, vilazodone..  Eur J Pharmacol,  510  (1-2):  (49-57).  [PMID:15740724]
4. Zhu XY, Etukala JR, Eyunni SV, Setola V, Roth BL, Ablordeppey SY.  (2012)  Benzothiazoles as probes for the 5HT1A receptor and the serotonin transporter (SERT): a search for new dual-acting agents as potential antidepressants..  Eur J Med Chem,  53  (13):  (124-32).  [PMID:22520153]
上海阿拉丁生化科技股份有限公司
销售条款及条件 ? ? ? ? 隐私政策
? 2016 ALADDIN-E.COM . 版权所有,未经授权禁止拷贝本站资料,如有违反,将追究法律责任
沪公网安备 31012002004058号 沪ICP备09093490号-2

本网站销售的所有产品仅用于工业应用或者科学研究等非医疗目的,不可用于人类或动物的临床诊断或者治疗,非药用,非食用。

上海工商 危险品化学品经营许可证（带存储）营业执照(三证合一)

91高清自产国产拍,无码免费A级毛片大全,日本 欧美 国产中文字幕,99re热视频这里只有精品视频首页

品牌简介

{转码主词}