人尿皮质素

内源性CRF激动剂

规格或纯度: ≥85% (HPLC)

CAS编号: 176591-49-4
分子式: C₂₀₄H₃₃₇N₆₃O₆₄
分子量: 4696.24
MDL号: MFCD00802621
PubChem编号: 137699473

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货号 (SKU)	包装规格	是否现货
U118944-0.5mg	0.5mg	期货
U118944-1mg	1mg	现货
U118944-5mg	5mg	现货

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CRF1 receptor Agonist CRF2 receptor Agonist

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基本描述

规格或纯度	≥85% (HPLC)
英文名称	Urocortin human
别名	Urocortin (human)
英文别名	Urocortin (human)
生化机理	内源性CRF激动剂。hCRF1，rCRF2α和mCRF2β的Kivalue分别为0.4、0.3和0.5 nM。
储存温度	-20°C储存
运输条件	超低温冰袋运输
备注	1mg、0.5mg卖完停产，不再备货
产品介绍	氨基酸序列 Asp-Asn-Pro-Ser-Leu-Ser-I?le-Asp-Leu-Thr-Phe-His-Le?u-Leu-Arg-Thr-Leu-Leu-Glu?-Leu-Ala-Arg-Thr-Gln-Ser-?Gln-Arg-Glu-Arg-Ala-Glu-G?ln-Asn-Arg-Ile-Ile-Phe-As?p-Ser-Val-NH2 Amino Acid Sequence Asp-Asn-Pro-Ser-Leu-Ser-I?le-Asp-Leu-Thr-Phe-His-Le?u-Leu-Arg-Thr-Leu-Leu-Glu?-Leu-Ala-Arg-Thr-Gln-Ser-?Gln-Arg-Glu-Arg-Ala-Glu-G?ln-Asn-Arg-Ile-Ile-Phe-As?p-Ser-Val-NH2

名称和标识符

IUPAC Name	4-[2-[[2-[[2-[[2-[[5-amino-2-[[2-[[5-amino-2-[[2-[[2-[2-[[2-[[2-[[2-[[2-[[2-[[2-[[2-[[2-[[2-[[2-[[2-[[2-[[2-[[2-[[2-[[2-[[2-[[1-[4-amino-2-[(2-amino-3-carboxypropanoyl)amino]-4-oxobutanoyl]pyrrolidine-2-carbonyl]amino]-3-hydroxypropanoyl]amino]-4-methylpentanoyl]amino]-3-hydroxypropanoyl]amino]-3-methylpentanoyl]amino]-3-carboxypropanoyl]amino]-4-methylpentanoyl]amino]-3-hydroxybutanoyl]amino]-3-phenylpropanoyl]amino]-3-(1H-imidazol-5-yl)propanoyl]amino]-4-methylpentanoyl]amino]-4-methylpentanoyl]amino]-5-carbamimidamidopentanoyl]amino]-3-hydroxybutanoyl]amino]-4-methylpentanoyl]amino]-4-methylpentanoyl]amino]-4-carboxybutanoyl]amino]-4-methylpentanoyl]amino]propanoylamino]-5-carbamimidamidopentanoyl]amino]-3-hydroxybutanoyl]amino]-5-oxopentanoyl]amino]-3-hydroxypropanoyl]amino]-5-oxopentanoyl]amino]-5-carbamimidamidopentanoyl]amino]-4-carboxybutanoyl]amino]-5-carbamimidamidopentanoyl]amino]propanoylamino]-5-[[5-amino-1-[[4-amino-1-[[1-[[1-[[1-[[1-[[1-[[1-[(1-amino-3-methyl-1-oxobutan-2-yl)amino]-3-hydroxy-1-oxopropan-2-yl]amino]-3-carboxy-1-oxopropan-2-yl]amino]-1-oxo-3-phenylpropan-2-yl]amino]-3-methyl-1-oxopentan-2-yl]amino]-3-methyl-1-oxopentan-2-yl]amino]-5-carbamimidamido-1-oxopentan-2-yl]amino]-1,4-dioxobutan-2-yl]amino]-1,5-dioxopentan-2-yl]amino]-5-oxopentanoic acid
INCHI	InChI=1S/C204H337N63O64/c1-28-100(20)154(262-191(323)140(90-271)257-180(312)127(75-96(12)13)247-189(321)138(88-269)259-192(324)141-52-42-70-267(141)199(331)136(83-146(210)279)255-163(295)111(205)81-150(286)287)193(325)254-135(85-152(290)291)185(317)246-129(77-98(16)17)187(319)266-159(107(27)274)198(330)253-131(79-109-45-35-32-36-46-109)181(313)248-132(80-110-86-222-91-228-110)183(315)245-126(74-95(10)11)178(310)243-124(72-93(6)7)176(308)235-116(51-41-69-227-204(220)221)174(306)265-158(106(26)273)197(329)251-128(76-97(14)15)179(311)244-125(73-94(8)9)177(309)239-122(58-64-149(284)285)170(302)242-123(71-92(4)5)175(307)230-104(24)161(293)231-114(49-39-67-225-202(216)217)173(305)264-157(105(25)272)196(328)241-119(55-61-144(208)277)171(303)256-137(87-268)188(320)240-117(53-59-142(206)275)166(298)234-113(48-38-66-224-201(214)215)165(297)238-121(57-63-148(282)283)168(300)233-112(47-37-65-223-200(212)213)164(296)229-103(23)162(294)232-120(56-62-147(280)281)167(299)237-118(54-60-143(207)276)169(301)249-133(82-145(209)278)184(316)236-115(50-40-68-226-203(218)219)172(304)261-156(102(22)30-3)195(327)263-155(101(21)29-2)194(326)252-130(78-108-43-33-31-34-44-108)182(314)250-134(84-151(288)289)186(318)258-139(89-270)190(322)260-153(99(18)19)160(211)292/h31-36,43-46,86,91-107,111-141,153-159,268-274H,28-30,37-42,47-85,87-90,205H2,1-27H3,(H2,206,275)(H2,207,276)(H2,208,277)(H2,209,278)(H2,210,279)(H2,211,292)(H,222,228)(H,229,296)(H,230,307)(H,231,293)(H,232,294)(H,233,300)(H,234,298)(H,235,308)(H,236,316)(H,237,299)(H,238,297)(H,239,309)(H,240,320)(H,241,328)(H,242,302)(H,243,310)(H,244,311)(H,245,315)(H,246,317)(H,247,321)(H,248,313)(H,249,301)(H,250,314)(H,251,329)(H,252,326)(H,253,330)(H,254,325)(H,255,295)(H,256,303)(H,257,312)(H,258,318)(H,259,324)(H,260,322)(H,261,304)(H,262,323)(H,263,327)(H,264,305)(H,265,306)(H,266,319)(H,280,281)(H,282,283)(H,284,285)(H,286,287)(H,288,289)(H,290,291)(H4,212,213,223)(H4,214,215,224)(H4,216,217,225)(H4,218,219,226)(H4,220,221,227)
InChi Key	BIIOOWPFSOAZSO-UHFFFAOYSA-N
Canonical SMILES	CCC(C)C(C(=O)NC(C(C)CC)C(=O)NC(CC1=CC=CC=C1)C(=O)NC(CC(=O)O)C(=O)NC(CO)C(=O)NC(C(C)C)C(=O)N)NC(=O)C(CCCNC(=N)N)NC(=O)C(CC(=O)N)NC(=O)C(CCC(=O)N)NC(=O)C(CCC(=O)O)NC(=O)C(C)NC(=O)C(CCCNC(=N)N)NC(=O)C(CCC(=O)O)NC(=O)C(CCCNC(=N)N)NC(=O)C(CCC(=O)N)NC(=O)C(CO)NC(=O)C(CCC(=O)N)NC(=O)C(C(C)O)NC(=O)C(CCCNC(=N)N)NC(=O)C(C)NC(=O)C(CC(C)C)NC(=O)C(CCC(=O)O)NC(=O)C(CC(C)C)NC(=O)C(CC(C)C)NC(=O)C(C(C)O)NC(=O)C(CCCNC(=N)N)NC(=O)C(CC(C)C)NC(=O)C(CC(C)C)NC(=O)C(CC2=CN=CN2)NC(=O)C(CC3=CC=CC=C3)NC(=O)C(C(C)O)NC(=O)C(CC(C)C)NC(=O)C(CC(=O)O)NC(=O)C(C(C)CC)NC(=O)C(CO)NC(=O)C(CC(C)C)NC(=O)C(CO)NC(=O)C4CCCN4C(=O)C(CC(=O)N)NC(=O)C(CC(=O)O)N
分子式	C₂₀₄H₃₃₇N₆₃O₆₄
PubChem CID	137699473
分子量	4696.24

化学和物理性质

溶解性	Soluble to 1 (mg/mL) in water}

靶标

Target ID

212

名称

CRF₁ receptor

缩写名

SHP2

家族

Corticotropin-releasing factor receptors

别名

HM3

基因和蛋白信息

Species	Transmembrane Domains	Amino Acids	Chromosomal Location	Gene Symbol	Gene Name
Rat	7	415	10q32.1	Crhr1	corticotropin releasing hormone receptor 1
Human	7	444	17q21.31	CRHR1	corticotropin releasing hormone receptor 1
Mouse	7	415	11 67.77 cM	Crhr1	corticotropin releasing hormone receptor 1

RefSeq Protein

NP_112261 (Rn) , NP_004373 (Hs) , NP_031788 (Mm)

UniProtKB

P35353 (Rn) , P34998 (Hs) , P35347 (Mm)

OMIM

122561 (Hs)

RefSeq Nucleotide

NM_004382 (Hs) , NM_030999 (Rn) , NM_007762 (Mm)

Entrez Gene

1394 (Hs) , 58959 (Rn) , 12921 (Mm)

Ensembl Gene

ENSG00000120088 (Hs) , ENSMUSG00000018634 (Mm) , ENSRNOG00000004900 (Rn)

Protein GI

6681013 (Mm) , 13591892 (Rn) , 372466597 (Hs)

GPCRdb

crfr1_human (Hs) , crfr1_mouse (Mm) , crfr1_rat (Rn)

UniProtKB ID/Entry name

CRFR1_HUMAN (Hs) , CRFR1_MOUSE (Mm) , CRFR1_RAT (Rn)

CATH/Gene3D

4.10.1240.10 (N/A)

ChEMBL Target

CHEMBL1800 (Hs) , CHEMBL2446 (Mm) , CHEMBL4649 (Rn)

Target ID

213

名称

CRF₂ receptor

缩写名

SHP2

家族

Corticotropin-releasing factor receptors

别名

HM3

基因和蛋白信息

Species	Transmembrane Domains	Amino Acids	Chromosomal Location	Gene Symbol	Gene Name
Rat	7	411	4q24	Crhr2	corticotropin releasing hormone receptor 2
Human	7	411	7p14.3	CRHR2	corticotropin releasing hormone receptor 2
Mouse	7	411	6 27.33 cM	Crhr2	corticotropin releasing hormone receptor 2

RefSeq Protein

NP_073205 (Rn) , NP_001874 (Hs) , NP_034083 (Mm)

UniProtKB

P47866 (Rn) , Q13324 (Hs) , Q60748 (Mm)

OMIM

602034 (Hs)

RefSeq Nucleotide

NM_001883 (Hs) , NM_022714 (Rn) , NM_009953 (Mm)

Entrez Gene

1395 (Hs) , 64680 (Rn) , 12922 (Mm)

Ensembl Gene

ENSG00000106113 (Hs) , ENSMUSG00000003476 (Mm) , ENSRNOG00000011145 (Rn)

Protein GI

12083687 (Rn) , 162138921 (Mm) , 321117257 (Hs)

GPCRdb

crfr2_human (Hs) , crfr2_mouse (Mm) , crfr2_rat (Rn)

UniProtKB ID/Entry name

CRFR2_HUMAN (Hs) , CRFR2_MOUSE (Mm) , CRFR2_RAT (Rn)

CATH/Gene3D

4.10.1240.10 (N/A)

ChEMBL Target

CHEMBL2253 (Mm) , CHEMBL4069 (Hs) , CHEMBL3581 (Rn)

关联配体

Ligand ID

919

名称

urocortin 1

类别

Peptide

学名

4-amino-N-(4,6-dimethylpyrimidin-2-yl)benzenesulfonamide

生物活性评价

The sulfonamide class of antibacterial compounds are primarily bacteriostatic agents and have a broad spectrum of activity against both Gram-positive and Gram-negative species of bacteria (reviewed in ).

评价

The human UCN sequence differs from mouse and rat sequences at residues 2 and 4 representing asparagine and serine respectively.

配体家族

Neuropeptides

基因/前体

Gene symbol	Gene name	Precursor protein name	Species	别名
UCN	urocortin	Urocortin (prepro-urocortin)	Human	UROC, UI

单字母多肽序列

DNPSLSIDLTFHLLRTLLELARTQSQRERAEQNRIIFDSV

三字母多肽序列

Asp-Asn-Pro-Ser-Leu-Ser-Ile-Asp-Leu-Thr-Phe-His-Leu-Leu-Arg-Thr-Leu-Leu-Glu-Leu-Ala-Arg-Thr-Gln-Ser-Gln-Arg-Glu-Arg-Ala-Glu-Gln-Asn-Arg-Ile-Ile-Phe-Asp-Ser-Val-NH2

翻译后修饰

The C-terminal valine is amidated

化学修饰

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人尿皮质素

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基本描述

名称和标识符

化学和物理性质

靶标

关联配体

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人尿皮质素

库存信息

库存信息

库存信息

基本描述

名称和标识符

化学和物理性质

靶标

关联配体

相关文档

质检报告COA

产品问答

产品问答

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