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TTT-3002

PubChem编号: 92136143

有货

库存信息

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库存信息

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货号 (SKU)	包装规格	是否现货	价格	数量
T614576-5mg	5mg	期货
T614576-25mg	25mg	期货

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fms related receptor tyrosine kinase 3 Inhibitor leucine rich repeat kinase 2 Inhibitor

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基本描述

英文名称	TTT-3002
别名	TTT3002
英文别名	TTT3002

名称和标识符

INCHI	InChI=1S/C27H23N5O3/c1-26-27(28,25(34)29-2)11-18(35-26)31-16-9-5-3-7-13(16)20-21-15(12-30-24(21)33)19-14-8-4-6-10-17(14)32(26)23(19)22(20)31/h3-10,18H,11-12,28H2,1-2H3,(H,29,34)(H,30,33)/t18-,26+,27-/m0/s1
InChi Key	DCAYZGCTSXLIHO-FYCNXDEQSA-N
Canonical SMILES	CNC(=O)[C@@]1(N)C[C@@H]2O[C@@]1(C)n1c3ccccc3c3c1c1n2c2ccccc2c1c1c3CNC1=O
PubChem CID	92136143

数据库链接

ChEBI	CHEBI:88219
PubChem CID	92136143
Reactome Reaction	R-HSA-9702508, R-HSA-9695828
Reactome Drug	R-ALL-9702989

关联配体

Ligand ID	11134
名称	TTT-3002
别名	TTT3002
类别	Synthetic organic
学名	4-amino-N-(4,6-dimethylpyrimidin-2-yl)benzenesulfonamide
生物活性评价	The antiproliferative activity of TTT-3002 in cancer cell lines is more potent in FLT3-dependent cells (those with activating mutations or high levels of WT expression and autocrine activation) compared to FLT3-independent cell lines .
评价	TTT-3002 is an experimental indolocarbazole kinase inhibitor. It was originally reported as a LRRK2 inhibitor (including activity against the G2019S and R1441C mutations) . Subsequent analysis revealed that TTT-3002 overcomes activating and drug resistance mutations in FLT3 in acute myeloid leukemia cells and is active against FLT3-associated leukemias in vitro and in vivo .

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参考文献

1. Yao C, Johnson WM, Gao Y, Wang W, Zhang J, Deak M, Alessi DR, Zhu X, Mieyal JJ, Roder H et al.. (2013) Kinase inhibitors arrest neurodegeneration in cell and C. elegans models of LRRK2 toxicity.. Hum Mol Genet, 22 (2): (328-44). [PMID:23065705]
2. Ma H, Nguyen B, Li L, Greenblatt S, Williams A, Zhao M, Levis M, Rudek M, Duffield A, Small D. (2014) TTT-3002 is a novel FLT3 tyrosine kinase inhibitor with activity against FLT3-associated leukemias in vitro and in vivo.. Blood, 123 (10): (1525-34). [PMID:24408321]
3. Ma HS, Nguyen B, Duffield AS, Li L, Galanis A, Williams AB, Brown PA, Levis MJ, Leahy DJ, Small D. (2014) FLT3 kinase inhibitor TTT-3002 overcomes both activating and drug resistance mutations in FLT3 in acute myeloid leukemia.. Cancer Res, 74 (18): (5206-17). [PMID:25060518]

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