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Trastuzumab (anti-HER2)

Trastuzumab (anti-HER2)

规格或纯度: Purity>95% (SDS-PAGE&SEC); Endotoxin Level<1.0EU/mg; Human IgG1; CHO; ELISA, FACS, Functional assay, Animal Model; Unconjugated

种属反应性: Human,Mouse?
亚型: Human IgG1

有货

库存信息

关闭

库存信息

关闭

库存信息

关闭

货号 (SKU)	包装规格	是否现货
T411999-1mg	1mg	期货
T411999-5mg	5mg	期货
T411999-10mg	10mg	期货

查看相关系列

erb-b2 receptor tyrosine kinase 2 Antibody

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基本信息

产品名称	Trastuzumab (anti-HER2)
规格或纯度	Purity>95% (SDS-PAGE&SEC); Endotoxin Level<1.0EU/mg; Human IgG1; CHO; ELISA, FACS, Functional assay, Animal Model; Unconjugated
特异性	ERBB2/HER2/CD340
应用	ELISA,Functional Assay,Flow cytometry,Kinetics (BLI),Kinetics (SPR)
反应种属	Human,Mouse?
偶联标记	Unconjugated

产品属性

抗体类型	Primary antibody
Format	Whole IgG
亚型	Human IgG1
轻链亚型	Kappa
SDS-PAGE	150 kDa
纯化方法	Protein A purified
来源	CHO supernatant
物理外观	Liquid
防腐剂	No
浓度	Lot by Lot
储存温度	-80℃储存,避免反复冻融
运输条件	超低温冰袋运输
稳定性与储存	Store at -80℃ for two years. Avoid freeze/thaw.
CAS编号和信息	180288-69-1

数据库链接

Wikipedia	Trastuzumab
IMGT/mAb-DB	97
PubChem SID	178101775
PEP	trastuzumab
Reactome Reaction	R-HSA-9652277, R-HSA-9665405, R-HSA-9649393, R-HSA-9665696, R-HSA-9665232
Reactome Drug	R-ALL-9634466

安全信息

象形图	Health Hazard
信号词	Danger
危险声明	H360: May damage fertility or the unborn child
预防措施声明	P280,P405,P501,P203,P318

靶标

Target ID

2019

名称

erb-b2 receptor tyrosine kinase 2

缩写名

HER2

家族

Type I RTKs: ErbB (epidermal growth factor) receptor family

别名

MAS-related GPR, member G

基因和蛋白信息

Species	Transmembrane Domains	Amino Acids	Chromosomal Location	Gene Symbol	Gene Name
Human	1	1255	17q12	ERBB2	erb-b2 receptor tyrosine kinase 2
Mouse	1	1256	11 D	Erbb2	erb-b2 receptor tyrosine kinase 2
Rat	1	1257	10q31	Erbb2	erb-b2 receptor tyrosine kinase 2

Ensembl Gene

ENSG00000141736 (Hs) , ENSMUSG00000062312 (Mm) , ENSRNOG00000006450 (Rn)

Entrez Gene

2064 (Hs) , 13866 (Mm) , 24337 (Rn)

OMIM

164870 (Hs)

UniProtKB

P04626 (Hs) , P06494 (Rn) , P70424 (Mm)

RefSeq Nucleotide

NM_001005862 (Hs) , NM_010194 (Mm) , NM_017003 (Rn)

RefSeq Protein

NP_001005862 (Hs) , NP_034324 (Mm) , NP_058699 (Rn)

Protein GI

111185914 (Mm) , 77020289 (Rn) , 54792098 (Hs)

DrugBank Target

P04626 (Hs)

CATH/Gene3D

3.80.20.20 (N/A)

ChEMBL Target

CHEMBL3848 (Rn) , CHEMBL2311234 (Mm) , CHEMBL1824 (Hs)

关联配体

Ligand ID

5082

名称

trastuzumab

别名

Herceptin®

类别

Antibody

学名

4-amino-N-(4,6-dimethylpyrimidin-2-yl)benzenesulfonamide

生物活性评价

The use of anti-HER2 monoclonals is covered by patent WO1989006692, in which the clone that produced trastuzumab is 4D5 . Efficacy of the resultant monoclonals was assessed in vitro (for example ELISA for antigen binding and in vitro cellular assays for anti-tumour activity) but no affinity value for the interaction between the antibody and its antigen are provided in the patent.

评价

Trastuzumab is a humanized IgG1κ monoclonal antibody targeting HER2.
Annotated peptide sequences for this antibody are available from its IMGT/mAb-DB record.

Biosimilars:

Name	Trade name	Company	Clinical Phase	Indications
trastuzumab-dkst; MYL-1401O	Hertraz; Canmab; Ogivri	Mylan and Biocon	Approved in India, FDA 2017, EMA 2018 (Ogivri)	Breast cancer
trastuzumab-pkrb; CT-P6	Herzuma; Credima	Celltrion	Approved in S Korea, EMA & FDA 2018	Breast cancer
trastuzumab-dttb; SB3	Ontruzant	Samsung Bioepis	Approved (EMA 2017, FDA 2019)	All approved indications of the reference product
trastuzumab-beta; trastuzumab-anns; ABP-980	Kanjinti	Amgen/Allergan	Approved (EMA 2018, FDA 2019)	All approved indications of the reference product
trastuzumab-qyyp; PF-05280014	Trazimera	Pfizer	Approved (FDA 2019; see REFLECTIONS B327-02 trial NCT01989676)	All approved indications of the reference product
HLX02	Zercepac	Shanghai Henlius Biotech; Accord Healthcare	Approved (EMA 2020)	Approved to treat HER2 positive metastatic breast cancer

单字母多肽序列

三字母多肽序列

翻译后修饰

化学修饰

参考文献

1. Mitri Z, Constantine T, O'Regan R. (2012) The HER2 Receptor in Breast Cancer: Pathophysiology, Clinical Use, and New Advances in Therapy.. Chemother Res Pract, 2012 (13): (743193). [PMID:23320171]
2. Paplomata E, Nahta R. (2018) ABP 980: promising trastuzumab biosimilar for HER2-positive breast cancer.. Expert Opin Biol Ther, 18 (3): (335-341). [PMID:29350568]