| 规格或纯度 | ≥95%(HPLC) |
|---|---|
| 英文名称 | Tocrifluor T1117 |
| 别名 | N-(哌啶-1-基)-5-(4-(4-(3-(5-羧酰胺基四甲基若丹明基)丙基)苯基)-1-(2,4-二氯苯基)-4-甲基-1H-吡唑-3-羧酰胺 |
| 英文别名 | Tocrifluor T1117|1186195-59-4|T1117|Tocrifluor 1117|5-[4-[4-[3-[[3',6'-bis(dimethylamino)-3-oxospiro[2-benzofuran-1,9'-xanthene]-5-carbonyl]amino]propyl]phenyl]phenyl]-1-(2,4-dichlorophenyl)-4-methyl-N-piperidin-1-ylpyrazole-3-carboxamide|N-(Piperidin-1-y |
| 生化机理 | AM 251的荧光形式。AM251与5-羧基四甲基罗丹明（5-TAMRA）结合，后者在543 nm激发下发荧光（发射590 nm）。显示GPR55结合活性。查看有关Tocrifluor T1117的更多信息。 |
| 储存温度 | -20°C储存 |
| 运输条件 | 超低温冰袋运输 |
| IUPAC Name | 5-[4-[4-[3-[[3',6'-bis(dimethylamino)-3-oxospiro[2-benzofuran-1,9'-xanthene]-5-carbonyl]amino]propyl]phenyl]phenyl]-1-(2,4-dichlorophenyl)-4-methyl-N-piperidin-1-ylpyrazole-3-carboxamide |
|---|---|
| INCHI | InChI=1S/C56H53Cl2N7O5/c1-34-51(54(67)61-64-28-7-6-8-29-64)60-65(48-26-20-40(57)31-47(48)58)52(34)38-17-15-37(16-18-38)36-13-11-35(12-14-36)10-9-27-59-53(66)39-19-23-44-43(30-39)55(68)70-56(44)45-24-21-41(62(2)3)32-49(45)69-50-33-42(63(4)5)22-25-46(50)56/h11-26,30-33H,6-10,27-29H2,1-5H3,(H,59,66)(H,61,67) |
| InChi Key | RNAPRXIZPJDYPH-UHFFFAOYSA-N |
| Canonical SMILES | CC1=C(N(N=C1C(=O)NN2CCCCC2)C3=C(C=C(C=C3)Cl)Cl)C4=CC=C(C=C4)C5=CC=C(C=C5)CCCNC(=O)C6=CC7=C(C=C6)C8(C9=C(C=C(C=C9)N(C)C)OC1=C8C=CC(=C1)N(C)C)OC7=O |
| 关联CAS | 1186195-59-4 |
| PubChem CID | 57369426 |
| 分子量 | 974.97 |
| 溶解性 | 溶于DMSO, 最高浓度 (mg/mL): 9.75, 最高浓度(mM): 10 |
|---|
| Ligand ID | 5560 |
|---|---|
| 名称 | T1117 |
| 别名 | tocrifluor T1117 |
| 类别 | Synthetic organic |
| 学名 | 5-[4-[4-[3-[[3',6'-bis(dimethylamino)-3-oxospiro[2-benzofuran-1,9'-xanthene]-5-carbonyl]amino]propyl]phenyl]phenyl]-1-(2,4-dichlorophenyl)-4-methyl-N-piperidin-1-ylpyrazole-3-carboxamide |
| 生物活性评价 |
The sulfonamide class of antibacterial compounds are primarily bacteriostatic agents and have a broad spectrum of activity against both Gram-positive and Gram-negative species of bacteria (reviewed in |
| 评价 | Sulfadimidine (sulfamethazine) is a sulfonamide antibacterial compound. This class of compounds are competitive inhibitors of bacterial dihydropteroate synthase (DHPS), an enzyme in the pathway which generates the folic acid that is essential for bacterial growth. |
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